ABSTRACT
Inhaled drugs are now routinely prescribed in daily medical practice. Recent topics about these treatments have been developed during the fourth annual meeting of the Groupe de travail aérosolthérapie (GAT) of the French-speaking respiratory society (Société de pneumologie de langue française). This article focuses mainly upon the choice of devices, systemic absorption of inhaled drugs and bitter taste receptors in the respiratory tract, a potential new target for drug development.
Subject(s)
Administration, Inhalation , Aerosol Propellants , Aerosols , Animals , Anti-Infective Agents/administration & dosage , Anti-Infective Agents/pharmacokinetics , Bronchodilator Agents/administration & dosage , Bronchodilator Agents/pharmacokinetics , Chemistry, Pharmaceutical , Equipment Design , Expectorants/administration & dosage , Expectorants/pharmacokinetics , Humans , Insulin/administration & dosage , Insulin/pharmacokinetics , Macrophages/drug effects , Macrophages/physiology , Muscle Relaxation/drug effects , Myocytes, Smooth Muscle/drug effects , Myocytes, Smooth Muscle/physiology , Nebulizers and Vaporizers/classification , Receptors, G-Protein-Coupled/drug effects , Receptors, G-Protein-Coupled/physiology , Respiratory System/drug effects , Tissue Distribution , Vasodilator Agents/administration & dosage , Vasodilator Agents/pharmacokineticsABSTRACT
The working group on aerosol therapy (GAT) of the Société de Pneumologie de Langue Française (SPLF) has organized its third Aerosolstorming in 2012. During one single day, different aspects of inhaled therapies have been treated and are detailed in two articles, this one being the second. This text deals with the indications of inhaled corticosteroids in ENT, the development and technical challenges of powder inhalers, the advantages and disadvantages of each type of technologies to measure the particle sizes of inhaled treatments.
