Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 5 de 5
Filter
Add more filters










Language
Publication year range
1.
Rev Soc Bras Med Trop ; 56: e02282023, 2023.
Article in English | MEDLINE | ID: mdl-37970877

ABSTRACT

Herein, we report two cases of severe mpox in patients with advanced acquired immunodeficiency syndrome from Brazil who developed atypical lesions and prolonged illness, one of whom had a fatal outcome. Both patients experienced serious complications involving the perianal and genital regions and prolonged disease with persistent viremia.


Subject(s)
Acquired Immunodeficiency Syndrome , Mpox (monkeypox) , Humans , Acquired Immunodeficiency Syndrome/complications , Mpox (monkeypox)/complications , Viremia/complications , Brazil
2.
J Med Virol ; 95(8): e29044, 2023 08.
Article in English | MEDLINE | ID: mdl-37605987

ABSTRACT

Several biomarkers have been evaluated as predictors of severity or in directing the treatment of COVID-19, however there are no conclusive results. In this study, we evaluated serum levels of cytokines, chemokines, and cell growth factors in association with the pathobiology of mild to moderate SARS-CoV-2 infection. Serum levels of SARS-CoV-2 infected patients (n = 113) and flu symptoms individuals negative for SARS-CoV-2 (n = 58), tested by the RT-qPCR test-nasal swab were compared to healthy controls (n = 53). Results showed that the proinflammatory cytokines IL-1ß, MCP-3, TNF-α, and G-CSF were increased in symptomatic patients and the cytokines IL-6 and IL-10 were associated with patients positive for SARS-CoV-2 when compared to healthy controls. Symptoms associated with COVID-19 were fever, anosmia, ageusia, and myalgia. For patients without SARS-CoV-2 infection, their major symptom was sore throat. The pathobiology of mild to moderate SARS-CoV-2 infection was associated with increasing proinflammatory cytokines and a pleiotropic IL-6 and anti-inflammatory IL-10 cytokines compared to healthy controls. Thus, knowledge about the pathophysiology and the involvement of biomarkers in the mild to moderate profile of the disease should be evaluated. Monitoring these biomarkers in patients with mild to moderate disease can help establish adequate treatment and prevention strategies for long-term COVID-19.


Subject(s)
COVID-19 , Cytokines , Humans , Interleukin-10 , Case-Control Studies , Interleukin-6 , SARS-CoV-2 , Chemokines
3.
Article in English | MEDLINE | ID: mdl-36946818

ABSTRACT

We report a case of COVID-19-associated meningoencephalitis with a fatal outcome in a male patient with concomitant influenza A, who had been hospitalized at the beginning of 2022, in the Northeastern region of Brazil. He died due to cardiopulmonary arrest after developing status epilepticus on the third day of hospitalization. The SARS-CoV-2 RNA was detected in cerebrospinal fluid and Influenza A was detected in the nasopharyngeal swab. Meningoencephalitis due to COVID-19 is a rare manifestation and physicians must be aware of this complication, mainly during the pandemic. In viral co-circulation situations, the possibility of respiratory coinfections should be remembered.


Subject(s)
COVID-19 , Influenza, Human , Meningoencephalitis , Humans , Male , COVID-19/complications , SARS-CoV-2 , RNA, Viral/genetics , Influenza, Human/complications , Influenza, Human/diagnosis , Meningoencephalitis/complications , Meningoencephalitis/diagnosis
4.
Article in English | LILACS-Express | LILACS | ID: biblio-1431355

ABSTRACT

ABSTRACT We report a case of COVID-19-associated meningoencephalitis with a fatal outcome in a male patient with concomitant influenza A, who had been hospitalized at the beginning of 2022, in the Northeastern region of Brazil. He died due to cardiopulmonary arrest after developing status epilepticus on the third day of hospitalization. The SARS-CoV-2 RNA was detected in cerebrospinal fluid and Influenza A was detected in the nasopharyngeal swab. Meningoencephalitis due to COVID-19 is a rare manifestation and physicians must be aware of this complication, mainly during the pandemic. In viral co-circulation situations, the possibility of respiratory coinfections should be remembered.

5.
Rev. Soc. Bras. Med. Trop ; 56: e0228, 2023. graf
Article in English | LILACS-Express | LILACS | ID: biblio-1521617

ABSTRACT

ABSTRACT Herein, we report two cases of severe mpox in patients with advanced acquired immunodeficiency syndrome from Brazil who developed atypical lesions and prolonged illness, one of whom had a fatal outcome. Both patients experienced serious complications involving the perianal and genital regions and prolonged disease with persistent viremia.

SELECTION OF CITATIONS
SEARCH DETAIL
...