ABSTRACT
Abstract Background: This study aimed to evaluate the relationship between quadriceps muscle thickness and functional performance on the 60s sit-to-stand test (60s-STS), the six-minute walk test (6MWT), and handgrip strength in non-dialytic stage 4 and 5 chronic kidney disease (CKD) patients. Methods: This was a cross-sectional study that evaluated 40 CKD patients aged between 30-70 years. Participants were submitted to an assessment that included quadriceps muscle thickness evaluated by a portable ultrasound. Functional performance tests included the 60s-STS, distance walked in the 6MWT, and handgrip strength. Also, body composition evaluated using electrical bioimpedance analysis and physical activity level through the short version of International Physical Activity were measured. Multiple linear regression was used to investigate the relationship between the quadriceps thickness and functional performance. Results: Quadriceps muscle thickness was correlated to 60s-STS (R2 = 43.6%; 95% CI = 0.022 - 0.665; β = 0.34; p = 0.037). Also, a moderate correlation between this muscle thickness and appendicular skeletal muscle (ALM) was found in CKD patients (r = 0.603, p <0.001). No relationship was found between quadriceps muscle thickness with the 6MWT and handgrip strength. Conclusion: Quadriceps muscle thickness is associated to 60s-STS, thus our results demonstrate the repercussions of the disease on the musculoskeletal system.
Resumo Antecedentes: Este estudo teve como objetivo avaliar a relação entre espessura muscular do quadríceps e desempenho funcional no teste sit-to-stand de 60s (STS-60s), no teste de caminhada de seis minutos (TC6M), e na força de preensão manual em pacientes não dialíticos com doença renal crônica (DRC) estágios 4 e 5. Métodos: Este foi um estudo transversal que avaliou 40 pacientes com DRC com idades entre 30-70 anos. Os participantes foram submetidos a uma avaliação que incluiu a espessura muscular do quadríceps avaliada por um ultrassom portátil. Os testes de desempenho funcional incluíram o STS-60s, a distância percorrida no TC6M e a força de preensão manual. Além disso, foram medidos a composição corporal, avaliada usando a análise de bioimpedância elétrica e o nível de atividade física por meio da versão curta do International Physical Activity. A regressão linear múltipla foi usada para investigar a relação entre a espessura do quadríceps e o desempenho funcional. Resultados: A espessura muscular do quadríceps foi correlacionada com o STS-60s (R2 = 43,6%; IC 95% = 0,022 - 0,665; β = 0,34; p = 0,037). Também foi encontrada uma correlação moderada entre esta espessura muscular e a massa muscular esquelética apendicular (MEA) em pacientes com DRC. (r = 0,603, p <0,001). Nenhuma relação foi encontrada entre a espessura muscular do quadríceps com o TC6M e a força de preensão manual. Conclusão: A espessura muscular do quadríceps está associada ao STS-60s, assim nossos resultados demonstram as repercussões da doença sobre o sistema músculo-esquelético.
ABSTRACT
BACKGROUND: This study aimed to evaluate the relationship between quadriceps muscle thickness and functional performance on the 60s sit-to-stand test (60s-STS), the six-minute walk test (6MWT), and handgrip strength in non-dialytic stage 4 and 5 chronic kidney disease (CKD) patients. METHODS: This was a cross-sectional study that evaluated 40 CKD patients aged between 30-70 years. Participants were submitted to an assessment that included quadriceps muscle thickness evaluated by a portable ultrasound. Functional performance tests included the 60s-STS, distance walked in the 6MWT, and handgrip strength. Also, body composition evaluated using electrical bioimpedance analysis and physical activity level through the short version of International Physical Activity were measured. Multiple linear regression was used to investigate the relationship between the quadriceps thickness and functional performance. RESULTS: Quadriceps muscle thickness was correlated to 60s-STS (R2 = 43.6%; 95% CI = 0.022 - 0.665; ß = 0.34; p = 0.037). Also, a moderate correlation between this muscle thickness and appendicular skeletal muscle (ALM) was found in CKD patients (r = 0.603, p <0.001). No relationship was found between quadriceps muscle thickness with the 6MWT and handgrip strength. CONCLUSION: Quadriceps muscle thickness is associated to 60s-STS, thus our results demonstrate the repercussions of the disease on the musculoskeletal system.
Subject(s)
Quadriceps Muscle , Renal Insufficiency, Chronic , Adult , Aged , Cross-Sectional Studies , Hand Strength/physiology , Humans , Middle Aged , Quadriceps Muscle/diagnostic imaging , Walk Test/methodsABSTRACT
BACKGROUND: Whole-body vibration (WBV) is an exercise modality that can promote improvements in heart rate variability (HRV) with lower patient overload, and consequently reduce cardiovascular risk in renal transplant patients. The aim of this study was to evaluate the effects of a 12-week WBV training program of two weekly sessions on HRV. METHODS: A double-blind, randomized controlled clinical trial with 12 kidney transplant recipients of both genders who underwent WBV training (35â¯Hz) twice a week for 12 weeks on alternate days (WBV Group) and training with sub-therapeutic WBV (8â¯Hz) (Sham Group). Variables were evaluated in time and frequency domains of HRV through the 24-h Holter monitor, heart rate (HR), blood pressure (BP) and maximum oxygen consumption (VO2max) through an exercise stress test. RESULTS: The delta between Sham and WBV groups showed an increase in the low frequency (Δâ¯=â¯959.05â¯Hz; pâ¯=â¯0.01) and in the high frequency (Δâ¯=â¯204.42â¯Hz; pâ¯=â¯0.04) of the HRV compared to Sham group. No changes in the ergometric variables were observed for any of the groups. CONCLUSION: The present study evidenced an increase in the low and high frequency of HRV in individuals who participated in the Sham WBV group. There was no improvement in the autonomic balance in the groups, in the other HRV parameters, or the exercise test after the WBV training period.
