Biomechanical Posture Analysis in Healthy Adults with Machine Learning: Applicability and Reliability.

Posture analysis is important in musculoskeletal disorder prevention but relies on subjective assessment. This study investigates the applicability and reliability of a machine learning (ML) pose estimation model for the human posture assessment, while also exploring the underlying structure of the data through principal component and cluster analyses. A cohort of 200 healthy individuals with a mean age of 24.4 ± 4.2 years was photographed from the frontal, dorsal, and lateral views. We used Student's t-test and Cohen's effect size (d) to identify gender-specific postural differences and used the Intraclass Correlation Coefficient (ICC) to assess the reliability of this method. Our findings demonstrate distinct sex differences in shoulder adduction angle (men: 16.1° ± 1.9°, women: 14.1° ± 1.5°, d = 1.14) and hip adduction angle (men: 9.9° ± 2.2°, women: 6.7° ± 1.5°, d = 1.67), with no significant differences in horizontal inclinations. ICC analysis, with the highest value of 0.95, confirms the reliability of the approach. Principal component and clustering analyses revealed potential new patterns in postural analysis such as significant differences in shoulder-hip distance, highlighting the potential of unsupervised ML for objective posture analysis, offering a promising non-invasive method for rapid, reliable screening in physical therapy, ergonomics, and sports.

Proposal of a Machine Learning Approach for Traffic Flow Prediction.

Rapid global urbanization has led to a growing urban population, posing challenges in transportation management. Persistent issues such as traffic congestion, environmental pollution, and safety risks persist despite attempts to mitigate them, hindering urban progress. This paper focuses on the critical need for accurate traffic flow forecasting, considered one of the main effective solutions for containing traffic congestion in urban scenarios. The challenge of predicting traffic flow is addressed by proposing a two-level machine learning approach. The first level uses an unsupervised clustering model to extract patterns from sensor-generated data, while the second level employs supervised machine learning models. Although the proposed approach requires the availability of data from traffic sensors to realize the training of the machine learning models, it allows traffic flow prediction in urban areas without sensors. In order to verify the prediction capability of the proposed approach, a real urban scenario is considered.

Digital Twin of a Water Supply System Using the Asset Administration Shell.

The concept of digital twins is one of the fundamental pillars of Industry 4.0. Digital twin allows the realization of a virtual model of a real system, enhancing the relevant performance (e.g., in terms of production rate, risk prevention, energy saving, and maintenance operation). Current literature presents many contributions pointing out the advantages that may be achieved by the definition of a digital twin of a water supply system. The Reference Architecture Model for Industry 4.0 introduces the concept of the Asset Administration Shell for the digital representation of components within the Industry 4.0 ecosystem. Several proposals are currently available in the literature considering the Asset Administration Shell for the realization of a digital twin of real systems. To the best of the authors' knowledge, at the moment, the adoption of Asset Administration Shell for the digital representation of a water supply system is not present in the current literature. For this reason, the aim of this paper is to present a methodological approach for developing a digital twin of a water supply system using the Asset Administration Shell metamodel. The paper will describe the approach proposed by the author and the relevant model based on Asset Administration Shell, pointing out that its implementation is freely available on the GitHub platform.

Proposal of Mapping Digital Twins Definition Language to Open Platform Communications Unified Architecture.

The concept of Digital Twin is of fundamental importance to meet the main requirements of Industry 4.0. Among the standards currently available to realize Digital Twins there is the Digital Twins Definition Language. Digital Twin requires exchange of data with the real system it models and with other applications that use the digital replica of the system. In the context of Industry 4.0, a reference standard for an interoperable exchange of information between applications, is Open Platform Communications Unified Architecture. The authors believe that interoperability between Digital Twins and Open Platform Communications Unified Architectures communication standard should be enabled. For this reason, the main goal of this paper is to allow a Digital Twin based on the Digital Twins Definition Language to exchange data with any applications compliant to the Open Platform Communications Unified Architecture. A proposal about the mapping from Digital Twins Definition Language to the Open Platform Communications Unified Architecture will be presented. In order to verify the feasibility of the proposal, an implementation has been made by the authors, and its description will be introduced in the paper. Furthermore, the main results of the validation process accomplished on the basis of this implementation will be given.

Integration of IoT Technologies into the Smart Grid.

This paper presents a novel solution in the field of the integration of the Smart Grid and the Internet of Things. The definition of a web platform able to offer a RESTful interface to IEC 61850 Servers to a generic user is proposed. The web platform enables the mapping of information maintained by an IEC 61850 Server into MQTT messages. Suitable mechanisms to introduce interoperable exchange of information were defined. The paper presents the main features offered by the proposed platform. The originality of the proposal is highlighted by comparing it with the current literature. A prototype was realized, and the software implementation choices are described and the main results of its evaluation are presented.

Semantic Interoperability between IEC 61850 and oneM2M for IoT-Enabled Smart Grids.

In the era of Industry 4.0, pervasive adoption of communication technologies based on the Internet of Things represents a very strong requirement in several domains. In the smart grid domain, there is the need to overcome one of the main limitations of the current electric grid, allowing the use of heterogeneous devices capable of measuring, monitoring and exchanging information about grid components. For this reason, current literature often presents research activities about enabling internet of things (IoT) in smart grids; in particular, several proposals aim to realize interworking between IoT and smart grid communication standards, allowing exchange of information between IoT devices and the electrical grid components. Semantic interoperability should be achieved in an interworking solution in order to provide a common meaning of the data exchanged by heterogeneous devices, even if they belong to different domains. Until now, semantic interoperability remains an open challenge in the smart grid field. The paper aims to propose a novel solution of interworking between two of the most used communication systems in smart grids and IoT domains, i.e., IEC 61850 and oneM2M, respectively. A semantic interoperability solution is also proposed to be used in the interworking scheme here presented.

A Model for Predictive Maintenance Based on Asset Administration Shell.

Maintenance is one of the most important aspects in industrial and production environments. Predictive maintenance is an approach that aims to schedule maintenance tasks based on historical data in order to avoid machine failures and reduce the costs due to unnecessary maintenance actions. Approaches for the implementation of a maintenance solution often differ depending on the kind of data to be analyzed and on the techniques and models adopted for the failure forecasts and for maintenance decision-making. Nowadays, Industry 4.0 introduces a flexible and adaptable manufacturing concept to satisfy a market requiring an increasing demand for customization. The adoption of vendor-specific solutions for predictive maintenance and the heterogeneity of technologies adopted in the brownfield for the condition monitoring of machinery reduce the flexibility and interoperability required by Industry 4.0. In this paper a novel approach for the definition of a generic and technology-independent model for predictive maintenance is presented. Such model leverages on the concept of the Reference Architecture Model for Industry (RAMI) 4.0 Asset Administration Shell, as a means to achieve interoperability between different devices and to implement generic functionalities for predictive maintenance.

Computational Modeling of PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer.

BACKGROUND: Malignant melanoma is an aggressive tumor of the skin and seems to be resistant to current therapeutic approaches. Melanocytic transformation is thought to occur by sequential accumulation of genetic and molecular alterations able to activate the Ras/Raf/MEK/ERK (MAPK) and/or the PI3K/AKT (AKT) signalling pathways. Specifically, mutations of B-RAF activate MAPK pathway resulting in cell cycle progression and apoptosis prevention. According to these findings, MAPK and AKT pathways may represent promising therapeutic targets for an otherwise devastating disease. RESULT: Here we show a computational model able to simulate the main biochemical and metabolic interactions in the PI3K/AKT and MAPK pathways potentially involved in melanoma development. Overall, this computational approach may accelerate the drug discovery process and encourages the identification of novel pathway activators with consequent development of novel antioncogenic compounds to overcome tumor cell resistance to conventional therapeutic agents. The source code of the various versions of the model are available as S1 Archive.

A methodological approach for using high-level Petri Nets to model the immune system response.

BACKGROUND: Mathematical and computational models showed to be a very important support tool for the comprehension of the immune system response against pathogens. Models and simulations allowed to study the immune system behavior, to test biological hypotheses about diseases and infection dynamics, and to improve and optimize novel and existing drugs and vaccines. Continuous models, mainly based on differential equations, usually allow to qualitatively study the system but lack in description; conversely discrete models, such as agent based models and cellular automata, permit to describe in detail entities properties at the cost of losing most qualitative analyses. Petri Nets (PN) are a graphical modeling tool developed to model concurrency and synchronization in distributed systems. Their use has become increasingly marked also thanks to the introduction in the years of many features and extensions which lead to the born of "high level" PN. RESULTS: We propose a novel methodological approach that is based on high level PN, and in particular on Colored Petri Nets (CPN), that can be used to model the immune system response at the cellular scale. To demonstrate the potentiality of the approach we provide a simple model of the humoral immune system response that is able of reproducing some of the most complex well-known features of the adaptive response like memory and specificity features. CONCLUSIONS: The methodology we present has advantages of both the two classical approaches based on continuous and discrete models, since it allows to gain good level of granularity in the description of cells behavior without losing the possibility of having a qualitative analysis. Furthermore, the presented methodology based on CPN allows the adoption of the same graphical modeling technique well known to life scientists that use PN for the modeling of signaling pathways. Finally, such an approach may open the floodgates to the realization of multi scale models that integrate both signaling pathways (intra cellular) models and cellular (population) models built upon the same technique and software.

A novel learning algorithm which improves the partial fault tolerance of multilayer neural networks.

The paper deals with the problem of fault tolerance in a multilayer perceptron network. Although it already possesses a reasonable fault tolerance capability, it may be insufficient in particularly critical applications. Studies carried out by the authors have shown that the traditional backpropagation learning algorithm may entail the presence of a certain number of weights with a much higher absolute value than the others. Further studies have shown that faults in these weights is the main cause of deterioration in the performance of the neural network. In other words, the main cause of incorrect network functioning on the occurrence of a fault is the non-uniform distribution of absolute values of weights in each layer. The paper proposes a learning algorithm which updates the weights, distributing their absolute values as uniformly as possible in each layer. Tests performed on benchmark test sets have shown the considerable increase in fault tolerance obtainable with the proposed approach as compared with the traditional backpropagation algorithm and with some of the most efficient fault tolerance approaches to be found in literature.