ABSTRACT
On earlier occasions healthy subjects, and chronic bronchopneumopathy patients were subjected to respiratory function tests in different postures using the plethysmographic and helium dilution methods. This protocol was then applied to a series of obese patients without the functional characteristics of alveolar hypoventilation identified in preliminary functional tests. The study revealed: a) non significant differences between plethysmographic and helium dilution findings; b) no significant volumetric differences produced by different postures (standing or squatting) especially as far as Total Lung Capacity is concerned. These results confirm the findings of others (Sharp et al., 1986) that diaphragmatic adjustment to changes in posture is inadequate in the obese even in the absence of hypoventilation.
Subject(s)
Diaphragm/physiopathology , Obesity/physiopathology , Posture , Respiratory Function Tests , Adult , Aged , Body Height , Body Weight , Compliance , Female , Forced Expiratory Flow Rates , Functional Residual Capacity , Humans , Male , Middle Aged , Residual Volume , Total Lung Capacity , Vital CapacitySubject(s)
Bronchial Diseases/drug therapy , Hemodynamics/drug effects , Isoquinolines/therapeutic use , Lung Diseases, Obstructive/drug therapy , Tretoquinol/therapeutic use , Adult , Blood Pressure/drug effects , Cardiac Output/drug effects , Central Venous Pressure/drug effects , Chronic Disease , Female , Heart/drug effects , Heart Rate/drug effects , Humans , Injections, Intravenous , Lung/drug effects , Male , Middle Aged , Pulmonary Circulation/drug effects , Respiratory Function Tests , Tretoquinol/administration & dosage , Vascular Resistance/drug effectsABSTRACT
A statistical correlation between anamnestic and hemodynamic data was performed in 40 patients with chronic obstructive lung disease and pulmonary hypertension at rest. Cardiopulmonary hemodynamic performance was significantly correlated with some of the assessed parameters, especially duration of illness and symptoms generally related with airway obstruction as dyspnea, cough and sputum.