ABSTRACT
A 2 1/2-year-old boy with eosinophilic granuloma confined to the frontoparietal bones developed a rectal fissure that progressed to a perianal plaque resembling condyloma latum. Biopsy confirmed the presence of many Langerhans cells, and therefore a diagnosis of eosinophilic granuloma involving the skin was made. Although rare, eosinophilic granuloma can be associated with cutaneous lesions, sometimes isolated and mundane in appearance. It should be considered in the differential diagnosis of perianal lesions.
Subject(s)
Anal Canal , Eosinophilic Granuloma/complications , Skin Diseases/etiology , Child, Preschool , Diagnosis, Differential , Eosinophilic Granuloma/pathology , Humans , Male , Skin/pathology , Skin Diseases/diagnosis , Skin Diseases/pathology , Syphilis, Cutaneous/diagnosisABSTRACT
A 0.25-mL quantity of 0.25%, 0.5%, and 1.0% polidocanol (Aethoxysclerol [France]), 0.5% sodium tetradecyl sulfate (Sotradecol injection), and 23.4% hypertonic saline was injected into the dorsal marginal rabbit ear vein; clinical and histologic thrombosis resulted that lasted between four and eight days. The lowest concentration of polidocanol (0.25%) demonstrated immediate thrombosis; however, no clinical or histologic changes occurred eight days after injection. With all other agents, histologic fibrosis of the vessel correlating with clinical disappearance occurred after eight days. However, 0.5% polidocanol and sodium tetradecyl sulfate developed recanalization through the initially sclerosed vessel between eight and 14 days, with clinical reappearance of the 0.5% polidocanol-injected vessel at 30 days, after injection. Cutaneous necrosis was noted clinically and histologically in three of ten vessels injected with 1.0% polidocanol and in two of ten vessels injected with hypertonic saline. Clinical and histologic evidence of necrosis occurred with and without extravasation of the sclerosants.
