The association between suicidality and treatment with selective serotonin reuptake inhibitors in older people with major depression: a systematic review.

BACKGROUND: Suicide among the elderly is an emerging public health issue. In Australia, suicide is a leading cause of death, most notably amongst elderly men over the age of 75. Depression is one of the main causes of suicide in older people. Selective serotonin reuptake inhibitors are considered to be a safe pharmacological therapy in the management of depression in adults. The risk of suicidality/suicide associated with the use of antidepressants in older people is unclear. OBJECTIVES: The objective of this review was to determine the association between treatment with selective serotonin reuptake inhibitors and suicidality/suicide in older people who suffer from major depression. TYPES OF PARTICIPANTS:   Consideration was given to studies that included older people aged 60 years and over, regardless of gender or ethnic background, with Diagnostic and Statistical Manual of Mental Disorders Fourth Edition or equivalent diagnostic criteria for Major Depressive Disorder without psychotic features.  Types of intervention(s)/phenomena of interest:  The review considered treatments using any selective serotonin reuptake inhibitors medication. Comparators included placebo or a different class of antidepressants including monoamine oxidase inhibitors or tricyclic antidepressants.  Types of studies:  This review considered both experimental and observational study designs including randomized controlled trials, non-randomized controlled trials, prospective and retrospective cohort studies and case control studies.  Types of outcomes:  The primary outcome measures of interest in this systematic review were worsening or emergent suicidal ideation, attempted suicide and completed suicide. For this systematic review, the term 'suicide attempt' referred to potentially self-injurious behavior with a non-fatal outcome. SEARCH STRATEGY: A three-step search strategy was employed that aimed to locate both published and unpublished studies in the English language. An initial search in PubMed was followed by a second search using all identified keywords and index terms across multiple databases and grey literature sites. Finally, the reference list of all identified reports and articles were searched for additional studies. METHODOLOGICAL QUALITY : Critical appraisal was undertaken by two independent reviewers using the standard critical appraisal instrument from the Joanna Briggs Institute Mata-Analysis of Statistical Assessment and Review Instrument. The McMaster Quality Assessment Scale for Harms was used to analyse reporting quality on suicide related harm. DATA COLLECTION: The primary data on the number of emergent or worsening of suicidal ideation, attempted suicide and completed suicides, in both arms of randomized controlled trials and observational studies was extracted using the standardized data extraction tool from the Joanna Briggs Institute Mata-Analysis of Statistical Assessment and Review Instrument. Baseline demographic data on each study was collected for presentation in tabular format. DATA SYNTHESIS: The data from randomized controlled trials and observational studies was pooled separately in statistical meta-analysis using RevMan V 5.1 software (The Cochrane Collaboration). Population demographic and other study characteristics were presented in tables and as a narrative summary. RESULTS: Following critical appraisal, eight randomized controlled trials and five observational studies (i.e. population cohort and retrospective case control studies) with data on suicide-related events were included in the systematic review. Based on the data on TRUNCATED AT 500 WORDS.

Upper-arm anthropometry: an alternative indicator of nutritional health to body mass index in unilateral lower-extremity amputees?

OBJECTIVE: To evaluate the utility of body mass index (BMI) and corrected-arm-muscle area (CAMA) as measures of nutritional health for lower-limb amputees attending prosthetics clinics. DESIGN: Cross-sectional study. SETTING: Prosthetics clinic in Australia. PARTICIPANTS: Unilateral lower-extremity amputees (N=58; age range, 21-91y; 37 transtibial, 21 transfemoral) attending a regional prosthetics clinic between May and November 2003. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Weight (without prosthesis), corrected and uncorrected for the amputated limb was used with height estimated from knee height to calculate corrected BMI (cBMI) and uncorrected BMI (uBMI). CAMA was calculated using the mean of triplicate mid-upper-arm circumference (MUAC) and triceps skinfold thickness (TST) measurements. The Mini Nutritional Assessment (MNA) and Assessment of Quality of Life were administered according to recommended protocols. The Pearson correlation was used to determine the strength and significance of associations between variables, and bivariate regression analyses were performed to determine whether an association existed between the nutritional variables (BMI, CAMA, MNA) and quality of life (QOL). RESULTS: There were no statistically significant differences in the measures of nutritional health according to site (transtibial, transfemoral) of amputation. MUAC, TST, and CAMA all showed moderate to high positive correlations (r range, .541-.782) with both cBMI and uBMI. The strength of the relationship between the MNA and cBMI/uBMI was weaker (r=.383, r=.380, respectively) but remained positive and statistically significant (P=.003). QOL was not associated with cBMI or uBMI but was related to CAMA (beta=-.132; P=.030) and MNA (beta=-.561; P=.017). CONCLUSIONS: For persons with unilateral lower-extremity amputation, measurement of upper-arm anthropometry may be a more useful indicator of nutritional health and its consequences than BMI.

Removable rigid dressings: a retrospective case-note audit to determine the validity of post-amputation application.

This study investigated the validity of post-amputation application of removable rigid dressings (RRDs) for trans-tibial amputees, regarding preparation for prosthetic management and key rehabilitation timelines. It was hypothesised that the use of RRDs would result in faster preparation of the residual limb for prosthetic management and shorter rehabilitation times, compared with conventional soft dressings. A retrospective case-note audit was conducted, in which consecutive trans-tibial amputees who underwent amputation in the 2 years before RRD implementation (non-RRD group, n = 37) and in the 2 years after RRD implementation (RRD group, n = 28) were eligible for inclusion. There was a significant reduction in the geometric mean time-to-first-prosthetic-casting in the RRD group, compared with the soft-dressing group (36.4 days vs. 27.6 days, respectively, p < 0.05). A significant reduction in acute length of stay (LOS) for the RRD group was also identified (15.9 days vs. 8.7 days, respectively, p < 0.001). There were no significant differences in other rehabilitation timeframes, such as rehabilitation LOS, total LOS, outpatient rehabilitation days, and total rehabilitation days between the two groups. This study shows that the application of RRDs reduces acute LOS and time-to-first-prosthetic-casting, thereby providing substantial benefits in preparing the trans-tibial amputee for early rehabilitation and prosthetic intervention.

Activity levels among lower-limb amputees: self-report versus step activity monitor.

OBJECTIVE: To determine the accuracy of self-reported activity by community-dwelling, lower-limb amputees. DESIGN: Descriptive study. SETTING: A regional prosthetics outpatient service. PARTICIPANTS: Seventy-seven unilateral lower-limb amputees at least 6 months after prosthetic rehabilitation. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Measured activity counts (in steps/min) and self-reported activity (rest, low, medium, high) in 15-minute intervals over 1 week were recorded for each participant. RESULTS: Participants averaged 3063+/-1893 steps per day. Strong agreement (gamma> or =0.7) between self-reported and measured activity was found for only 34% of participants between the hours of 9:00 am to 9:00 pm. The measured and self-reported proportion of time spent in various states of activity also showed poor agreement (rest, r=.41; low level activity, r=.39; medium level, r=.26; high level, r=.40). There was no bias toward either over- or under-reporting. CONCLUSIONS: The majority of participants were unable to accurately self-report their activity levels (sleep excluded) as compared with measured activity levels. This may have important implications for prescribing appropriate prosthetics and for clinicians who provide patients with advice on promoting health.