1.
Eur Neuropsychopharmacol
; 10(5): 419-21, 2000 Sep.
Article
in English
| MEDLINE
| ID: mdl-10974616
ABSTRACT
Injection of high doses of cholecystokinin tetrapeptide (CCK-4), a recent experimental model for panic, causes panic attacks and respiratory stimulation, a key feature of panic, in healthy volunteers. However, it has not yet been established whether respiratory stimulation is specifically linked to panic or merely an effect of arousal in general. Results of the present study show that respiratory stimulation is not merely linked to higher arousal and suggest a link between CCK-provoked panic and respiratory stimulation.
Subject(s)
Respiratory Mechanics/drug effects , Tetragastrin/pharmacology , Anxiety , Cross-Over Studies , Dose-Response Relationship, Drug , Double-Blind Method , Heart Rate/drug effects , Humans , Injections, Intravenous , Multivariate Analysis , Panic , Placebos , Reference Values , Tetragastrin/administration & dosage
2.
Biol Psychiatry
; 36(4): 266-8, 1994 Aug 15.
Article
in English
| MEDLINE
| ID: mdl-7986891