Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 8 de 8
Filter
Add more filters










Database
Language
Publication year range
1.
Eur J Clin Nutr ; 62(9): 1116-22, 2008 Sep.
Article in English | MEDLINE | ID: mdl-17538537

ABSTRACT

OBJECTIVE: Fish oil (FO) may attenuate the inflammatory response after major surgery such as abdominal aortic aneurysm (AAA) surgery. We aimed at evaluating the clinical impact and safety aspects of a FO containing parenteral nutrition (PN) after AAA surgery. METHODS: Intervention consisted in 4 days of either standard (STD: Lipofundin medium-chain triglyceride (MCT): long-chain triglyceride (LCT)50%-MCT50%) or FO containing PN (FO: Lipoplus: LCT40%-MCT50%-FO10%). Energy target were set at 1.3 times the preoperative resting energy expenditure by indirect calorimetry. Blood sampling on days 0, 2, 3 and 4. Glucose turnover by the (2)H(2)-glucose method. Muscle microdialysis. CLINICAL DATA: maximal daily T degrees, intensive care unit (ICU) and hospital stay. RESULTS: Both solutions were clinically well tolerated, without any differences in laboratory safety parameters, inflammatory, metabolic data, or in organ failures. Plasma tocopherol increased similarly; with FO, docosahexaenoic and eicosapentaenoic acid increased significantly by day 4 versus baseline or STD. To increased postoperatively, with a trend to lower values in FO group (P=0.09). After FO, a trend toward shorter ICU stay (1.6+/-0.4 versus 2.3+/-0.4), and hospital stay (9.9+/-2.4 versus 11.3+/-2.7 days: P=0.19) was observed. CONCLUSIONS: Both lipid emulsions were well tolerated. FO-PN enhanced the plasma n-3 polyunsaturated fatty acid content, and was associated with trends to lower body temperature and shorter length of stay.


Subject(s)
Aortic Aneurysm, Abdominal/surgery , Fish Oils/therapeutic use , Lipids/blood , Phospholipids/therapeutic use , Postoperative Care , Sorbitol/therapeutic use , Aged , Aged, 80 and over , Blood Glucose/metabolism , Body Temperature , Double-Blind Method , Drug Combinations , Female , Humans , Lactates/metabolism , Male , Microdialysis , Middle Aged , Muscle, Skeletal/metabolism , Parenteral Nutrition
2.
Eur J Clin Nutr ; 59(2): 307-10, 2005 Feb.
Article in English | MEDLINE | ID: mdl-15508015

ABSTRACT

OBJECTIVE: Safety and intestinal tolerance of an early high-dose enteral administration of antioxidative vitamins, trace elements, and glutamine dipeptides. DESIGN: open intervention trial. SETTING: Two university teaching hospitals. PATIENTS: A total of 14 patients requiring jejunal feeding (64+/-14 y). INTERVENTION: A measure of 500 ml/day Intestamin (FreseniusKabi: 250 kcal/1.050 kJ, 300 microg selenium, 20 mg zinc, 400 mug chromium, 1500 mg vitamin C, 500 mg vitamin E, 10 mg beta-carotene, 30 g glutamine) for 5 days beginning 6 h after surgery. Parenteral/enteral nutrition was provided to achieve energy target (25 kcal/kg/day). ASSESSMENTS: Intestinal complaints, plasma nutrients, and glutathione. RESULTS: Only minor signs of nausea, hiccups, flatulence (3/14). Plasma micronutrients (except beta-carotene) postoperatively decreased and increased to normal on day 5. Extracellular glutamine remained low (preop: 520+/-94; d1: 357+/-67; d5: 389+/-79 micromol/l); total glutathione decreased (d1: 9.4+/-3.8; d5: 3.6+/-2.5 micromol/l). CONCLUSION: Study feed is well tolerated and metabolically safe representing a valuable tool for targeted pharmaconutrient supply.


Subject(s)
Antioxidants/administration & dosage , Enteral Nutrition , Gastrointestinal Neoplasms/therapy , Glutamine/administration & dosage , Trace Elements/administration & dosage , Antioxidants/metabolism , Female , Food, Formulated/adverse effects , Gastrointestinal Neoplasms/surgery , Glutamine/metabolism , Humans , Intestinal Absorption , Jejunostomy , Male , Middle Aged , Postoperative Care/methods , Safety , Time Factors , Trace Elements/metabolism , Treatment Outcome
3.
Crit Care Med ; 28(12): 3784-91, 2000 Dec.
Article in English | MEDLINE | ID: mdl-11153615

ABSTRACT

BACKGROUND: Hyperlactatemia is a prominent feature of cardiogenic shock. It can be attributed to increased tissue production of lactate related to dysoxia and to impaired utilization of lactate caused by liver and tissue underperfusion. The aim of this prospective observational study was to determine the relative importance of these mechanisms during cardiogenic shock. PATIENTS: Two groups of subjects were compared: seven cardiac surgery patients with postoperative cardiogenic shock and seven healthy volunteers. METHODS: Lactate metabolism was assessed by using two independent methods: a) a pharmacokinetic approach based on lactate plasma level decay after the infusion of 2.5 mmol x kg(-1) of sodium lactate; and b) an isotope dilution technique for which the transformation of [13C]lactate into [13C]glucose and 13CO2 was measured. Glucose turnover was determined using 6,62H2-glucose. RESULTS: All patients suffered from profound shock requiring high doses of inotropes and vasopressors. Mean arterial lactate amounted to 7.8 +/- 3.4 mmol x L(-1) and mean pH to 7.25 +/- 0.07. Lactate clearance was not different in the patients and controls (7.8 +/- 3.4 vs. 10.3 +/- 2.1 mL x kg(-1) x min(-1)). By contrast, lactate production was markedly enhanced in the patients (33.6 +/- 16.4 vs. 9.6 +/- 2.2 micromol x kg(-1) x min(-1); p < .01). Exogenous [13C]lactate oxidation was not different (107 +/- 37 vs. 103 +/- 4 mmol), and transformation of [13C]lactate into [13C]glucose was not different (20.0 +/- 13.7 vs. 15.2% +/- 6.0% of exogenous lactate). Endogenous glucose production was markedly increased in the patients (1.95 +/- 0.26 vs. 5.3 +/- 3.0 mg x kg(-1) x min(-1); p < .05 [10.8 +/- 1.4 vs. 29.4 +/- 16.7 micromol x kg(-1) x min(-1)]), whereas net carbohydrate oxidation was not different (1.7 +/- 0.5 vs. 1.3 +/- 0.3 mg x kg(-1) x min(-1) [9.4 +/- 2.8 vs. 7.2 +/- 1.7 micromol x kg(-1) x min(-1)]). CONCLUSIONS: Hyperlactatemia in early postoperative cardiogenic shock was mainly related to increased tissue lactate production, whereas alterations of lactate utilization played only a minor role. Patients had hyperglycemia and increased nonoxidative glucose disposal, suggesting that glucose-induced stimulation of tissue glucose uptake and glycolysis may contribute significantly to hyperlactatemia.


Subject(s)
Acidosis, Lactic/etiology , Acidosis, Lactic/metabolism , Cardiac Surgical Procedures/adverse effects , Glucose/metabolism , Hyperglycemia/etiology , Hyperglycemia/metabolism , Lactic Acid/metabolism , Shock, Cardiogenic/etiology , Shock, Cardiogenic/metabolism , Adult , Aged , Bilirubin/blood , Case-Control Studies , Female , Glycolysis , Hemodynamics , Humans , Hydrocortisone/blood , Liver/metabolism , Male , Middle Aged , Oxidation-Reduction , Prospective Studies , Shock, Cardiogenic/mortality , Shock, Cardiogenic/physiopathology , Sodium Lactate/administration & dosage , Sodium Lactate/pharmacokinetics , Survival Analysis , Tissue Distribution
4.
Nutrition ; 13(10): 870-7, 1997 Oct.
Article in English | MEDLINE | ID: mdl-9357023

ABSTRACT

Total parenteral nutrition (TPN) has long been considered the optimal nutrition technique in critically ill patients, but recently the use of enteral nutrition (EN) has increased. This study describes the evolution of the different nutritional support techniques in a surgical intensive care unit (ICU) in a university hospital, through (1) a global survey over 10 y assessing the evolution of the use of EN and TPN, and (2) a prospective study performed over 6 mo. Severity of illness and diagnostic categories were stable (n = 11,539 patients). From 1986 to 1990, the proportion of TPN administered increased from 10-25% of ICU days, decreasing to 10% thereafter. EN was used in about 5% of ICU days in 1986, and had increased to 30% of total ICU treatment days in 1995. The proportion of nutrients actually delivered to the patients was 75% with EN and 88% with TPN. Major changes in nutritional support have been observed since 1986. The frequency of nutritional support provided in general has increased to 40% of ICU treatment days. TPN has been largely overtaken by EN, with the risk of insufficient energy delivery, related to the difficulties of EN in the critically ill. These results reinforce the importance of continuous quality control by daily assessment of nutrient supply.


Subject(s)
Intensive Care Units/statistics & numerical data , Nutritional Support/statistics & numerical data , Adult , Aged , Enteral Nutrition/methods , Enteral Nutrition/statistics & numerical data , Enteral Nutrition/trends , Health Surveys , Humans , Middle Aged , Nutritional Support/methods , Nutritional Support/trends , Parenteral Nutrition/methods , Parenteral Nutrition/statistics & numerical data , Parenteral Nutrition/trends , Time Factors
5.
Clin Physiol ; 16(4): 393-401, 1996 Jul.
Article in English | MEDLINE | ID: mdl-8842575

ABSTRACT

Sodium lactate inhibits ventilation when infused in healthy human subjects. This effect has been attributed to lactate-induced metabolic alkalosis. In order to further delineate the mechanisms responsible for this depression of ventilation, healthy humans were infused with sodium lactate with or without acetazolamide. Sodium lactate increased blood pH from 7.37 +/- 0.02 to 7.47 +/- 0.01 and induced a sustained urinary excretion of bicarbonate. PO2 of arterialized blood decreased by 10.3 +/- 2.1 mmHg, indicating an inhibition of ventilation. Acetazolamide decreased lactate-induced alkalinisation of blood (pH after lactate + acetazolamide 7.42 +/- 0.02), but did not prevent the drop in PO2. Acetazolamide alone tended to stimulate ventilation, as indicated by an increase in PO2. These results indicate that sodium lactate inhibits ventilation independently of changes in systemic blood pH. Alkalinization of the cerebrospinal fluid, or other central effects of lactate, is probably responsible for this ventilatory depression.


Subject(s)
Acid-Base Equilibrium/drug effects , Alkalosis/metabolism , Respiration/drug effects , Sodium Lactate/pharmacology , Acetazolamide/administration & dosage , Acetazolamide/pharmacology , Adult , Alkalosis/chemically induced , Alkalosis/drug therapy , Blood Gas Analysis , Carbonic Anhydrase Inhibitors/administration & dosage , Carbonic Anhydrase Inhibitors/pharmacology , Drug Combinations , Humans , Hydrogen-Ion Concentration , Infusions, Intravenous , Male , Reference Values , Respiration/physiology , Sodium Bicarbonate/urine , Sodium Lactate/administration & dosage
6.
Diabete Metab ; 21(5): 345-52, 1995 Dec.
Article in English | MEDLINE | ID: mdl-8586151

ABSTRACT

To assess the effects of lactate on glucose metabolism, sodium lactate (20 mumol.kg-1.min-1) was infused into healthy subjects in basal conditions and during application of a hyperinsulinaemic (6 pmol.kg-1.min-1) euglycaemic clamp. Glucose rate of appearance (GRa) and disappearance (GRd) were measured from plasma dilution of infused U- 13C glucose, and glucose oxidation (G(ox)) from breath 13CO2 and plasma 13C glucose. In basal conditions, lactate infusion did not alter G(ox) (8.8 +/- 0.9 vs 9.2 +/- 1.1 mumol.kg-1.min-1), while GRa slightly decreased from 15.2 +/- 0.8 basal to 13.9 +/- 0.9 mumol.kg-1.min-1 after lactate (p < 0.05). During a hyperinsulinaemic clamp, hepatic glucose production was completely suppressed with or without lactate. Lactate decreased G(ox) from 17.1 +/- 0.4 to 13.4 +/- 1.2 mumol.kg-1.min-1 (p < 0.05), whereas GRd was unchanged (39.7 +/- 3.6 vs 45.6 +/- 2.6 mumol.kg-1.min-1. It is concluded that infusion of lactate in basal conditions does not increase GRa or interfere with peripheral glucose oxidation, and that during hyperinsulinaemia lactate decreases glucose oxidation but does not alter hepatic or peripheral insulin sensitivity.


Subject(s)
Blood Glucose/metabolism , Energy Metabolism/drug effects , Lactates/pharmacology , Analysis of Variance , Basal Metabolism , Bicarbonates/blood , Bicarbonates/urine , Female , Humans , Hydrogen-Ion Concentration , Hyperinsulinism/blood , Kinetics , Lactic Acid , Male , Oxidation-Reduction , Reference Values
7.
Am J Physiol ; 268(4 Pt 1): E630-5, 1995 Apr.
Article in English | MEDLINE | ID: mdl-7733261

ABSTRACT

Hepatic glucose production is autoregulated during infusion of gluconeogenic precursors. In hyperglycemic patients with multiple trauma, hepatic glucose production and gluconeogenesis are increased, suggesting that autoregulation of hepatic glucose production may be defective. To better understand the mechanisms of autoregulation and its possible alterations in metabolic stress, lactate was coinfused with glucose in healthy volunteers and in hyperglycemic patients with multiple trauma or critical illness. In healthy volunteers, infusion of glucose alone nearly abolished endogenous glucose production. Lactate increased gluconeogenesis (as indicated by a decrease in net carbohydrate oxidation with no change in total [13C]carbohydrate oxidation) but did not increase endogenous glucose production. In patients with metabolic stress, endogenous glucose production was not suppressed by exogenous glucose, but lactate did not further increase hepatic glucose production. It is concluded that 1) in healthy humans, autoregulation of hepatic glucose production during infusion of lactate is still present when glycogenolysis is suppressed by exogenous glucose and 2) autoregulation of hepatic glucose production is not abolished in hyperglycemic patients with metabolic stress.


Subject(s)
Glucose/metabolism , Hyperglycemia/etiology , Hyperglycemia/metabolism , Lactates/pharmacology , Wounds and Injuries/complications , Adolescent , Adult , Aged , Blood Glucose/analysis , Critical Illness , Energy Metabolism , Female , Homeostasis , Humans , Insulin/blood , Lactates/administration & dosage , Lactates/blood , Lactic Acid , Liver/metabolism , Male , Middle Aged , Parenteral Nutrition, Total , Reference Values
8.
Am J Clin Nutr ; 58(5): 608-13, 1993 Nov.
Article in English | MEDLINE | ID: mdl-8237864

ABSTRACT

Infusion of sodium acetate in lean humans results in a decrease in respiratory exchange ratio, which may be advantageous in patients with respiratory failure. However, this potential decrease in respiratory work was observed to be offset by significant thermogenesis. The metabolic effects of sodium acetate, sodium lactate, and sodium beta-hydroxybutyrate, infused at a rate of 20 mumol.kg-1.min-1 for 3 h, was monitored in six healthy human volunteers. Respiratory exchange ratio decreased from 0.85 +/- 0.02 at baseline to 0.75 +/- 0.02, 0.75 +/- 0.02, and 0.80 +/- 0.02, after acetate, lactate, or beta-hydroxybutyrate, respectively (P < 0.05 for each). Acetate produced a larger thermic effect (22.7% of energy infused) than did lactate (16.3%) or beta-hydroxybutyrate (13.6%). Thus, sodium salts of organic acids may potentially decrease the respiratory requirements by decreasing the respiratory exchange ratio. However, this effect is partially offset by the thermic effect of these substrates. The maximal doses and safety of these anions during larger infusion periods remain to be determined.


Subject(s)
Acetates/pharmacology , Energy Metabolism/drug effects , Hydroxybutyrates/pharmacology , Lactates/pharmacology , 3-Hydroxybutyric Acid , Acetic Acid , Adult , Female , Humans , Infusions, Intravenous , Lactic Acid , Male , Models, Theoretical , Oxidation-Reduction
SELECTION OF CITATIONS
SEARCH DETAIL
...