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Farmaco Sci ; 40(8): 581-8, 1985 Aug.
Article in English | MEDLINE | ID: mdl-3876240

ABSTRACT

Sixteen N-substituted urethanes were investigated as potential antiinflammatory agents. Most of them showed no stronger activity than phenylbutazone. The most active in the xylene hyperemia test were N,N'-dicarbethoxy-N,N'-dicyclohexyl-1,3-diaminopropane (XVI) and cyclohexyl piperidine-1-carboxylate (XIII). None of the studied compounds showed analgesic activity.


Subject(s)
Anti-Inflammatory Agents/chemical synthesis , Urethane/analogs & derivatives , Animals , Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis , Chemical Phenomena , Chemistry , Edema/drug therapy , Granuloma/drug therapy , Rats , Rats, Inbred Strains , Urethane/pharmacology
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