Subject(s)
Dermatomyositis/pathology , Dermatomyositis/surgery , Polyarteritis Nodosa/pathology , Polyarteritis Nodosa/surgery , Amputation, Surgical , Debridement , Disease Progression , Female , Humans , Leg/pathology , Leg/surgery , Middle Aged , Negative-Pressure Wound Therapy , Reoperation , Skin Ulcer/etiology , Skin Ulcer/pathology , Surgical FlapsABSTRACT
OBJECTIVE: Wound healing in burn wounds presents a challenge in healthcare, and there is still a lack of alternatives in topical burn wound treatments. - The purpose of this study was to evaluate the efficacy of a new therapeutic ointment (MEBO) in the treatment of partial thickness burns. METHODS: 40 patients received either topical treatment with Moist Exposed Burn Ointment (MEBO) or standard Flammazine treatment. All patients suffered from partial-thickness burn injuries (< 20% TBSA). Wounds were evaluated for 60 up to days regarding wound healing, water loss, inflammation, and pain alleviation. RESULTS: For transepidermal water loss, there was a difference of 2.3 gr/m2/h between MEBO, and Flammazine, favoring MEBO. However, this difference was not statistically significant (p=0.78). For all secondary efficacy parameter results were similar. - CONCLUSIONS: This study showed that MEBO ointment for topical treatment of burn injuries presents an attractive alternative for the topical treatment of limited partial thickness thermal burns.
Subject(s)
Anti-Infective Agents, Local/administration & dosage , Burns/drug therapy , Ointments/administration & dosage , Silver Sulfadiazine/administration & dosage , Administration, Topical , Adolescent , Adult , Aged , Bandages , Female , Humans , Male , Middle Aged , Pain Threshold/drug effects , Severity of Illness Index , Treatment Outcome , Water/metabolism , Wound Healing/drug effects , Young AdultABSTRACT
In patients with sarcomas, or regional recurrence of the disease, radical resection and radiation therapy is indicated to achieve cure or palliation. As a result of radical surgery, extensive radiation, or infection in the pelvic, groin or thigh region, the development of large pelvic / groin / thigh defects present a difficult surgical problem. Musculocutaneous deep epigastric island-flaps, as a modification of the extended deep inferior epigastric flap, described by Taylor et al. in 1983, are an attractive option for a successful reconstruction for this defect localisation. Two technical modifications of the contralateral extended deep inferior epigastric island-flap permitted an adequate tailoring to a defect in the posterior lateral pelvic or groin-thigh region, and avoided the drawbacks of other loco-regional or microsurgical flaps in previously irradiated fields. The skin island reached the posterior lateral pelvic region, groin or thigh. The muscular portion of this flap was suited to fill the soft tissue defects in these critical areas. These so modified flaps represent an instrument, which in selected cases may be an interesting alternative tool for closure of complex defects. No significant functional impairment secondary to the flap procedures was noted in our patients.
