CELPI: trial protocol for a randomised controlled trial of a Carer End of Life Planning Intervention in people dying with dementia.

BACKGROUND: Dementia is a leading cause of death in developed nations. Despite an often distressing and symptom laden end of life, there are systematic barriers to accessing palliative care in older people dying of dementia. Evidence exists that 70% of people living with severe dementia attend an emergency department (ED) in their last year of life. The aim of this trial is to test whether a Carer End of Life Planning Intervention (CELPI), co-designed by consumers, clinicians and content specialists, improves access to end of life care for older people with severe dementia, using an ED visit as a catalyst for recognising unmet needs and specialist palliative care referral where indicated. METHODS: A randomised controlled trial (RCT) enrolling at six EDs across three states in Australia will be conducted, enrolling four hundred and forty dyads comprising a person with severe dementia aged ≥ 65 years, and their primary carer. Participants will be randomly allocated to CELPI or the control group. CELPI incorporates a structured carer needs assessment and referral to specialist palliative care services where indicated by patient symptom burden and needs assessment. The primary outcome measure is death of the person with dementia in the carer-nominated preferred location. Secondary outcomes include carer reported quality of life of the person dying of dementia, hospital bed day occupancy in the last 12 months of life, and carer stress. An economic evaluation from the perspective of a health funder will be conducted. DISCUSSION: CELPI seeks to support carers and provide optimal end of life care for the person dying of dementia. This trial will provide high level evidence as to the clinical and cost effectiveness of this intervention. TRIAL REGISTRATION: ACTRN12622000611729 registered 22/04/2022.

Medical students' opinions on professional behaviours: The Professionalism of Medical Students' (PoMS) study.

Introduction: The Professionalism of Medical Students (PoMS) study aimed to develop a comprehensive understanding of Australian and New Zealand (Aus/NZ) medical students' opinions and experience with professionalism dilemmas.Methods: A confidential, online survey for medical students was developed and distributed to all Aus/NZ medical schools. Students submitted de-identified demographic information, gave opinions on the acceptability of a range of student behaviours for professionally challenging situations, and whether they had encountered similar situations.Results: 3171 medical students participated from all 21 Aus/NZ medical schools (16% of the total student population). Medical students reported encountering many of the professionally challenging situations and had varying opinions on what was acceptable behaviour for the scenarios. In general, students' opinions were not influenced by the seniority, gender or the type of health professional involved in the scenario. Participant demographic factors appeared to have significant effects on professional opinions - particularly male gender and being a student in the latter stages of the course.Discussion: Medical students' professional opinions are a complex area. The PoMS data provides a reference point for students, their educators and other health professionals in identifying current student professional behaviour norms, determining the effects of demographic factors on their decision making, and where important gaps exist in medical students' approaches to professionalism.

A randomised trial comparing a 4-stage to 2-stage teaching technique for laryngeal mask insertion.

OBJECTIVE: To compare the '4-stage' teaching technique (demonstration, deconstruction, formulation, performance) with the traditional '2-stage' teaching technique (deconstruction, performance) in laryngeal mask airway (LMA) insertion. METHODS: Using a prospective randomised study design, participants were taught LMA insertion on a manikin by either the '2-stage' or '4-stage' teaching method. Subjects were eligible if they had never inserted a LMA. Skill acquisition was assessed immediately following training, and skill retention assessed a number of weeks later. The primary outcome was LMA insertion on a manikin, with successful ventilation within 30 s. Other outcomes included overall time to LMA insertion, and number of errors. Assessors were blinded to the teaching method used for each subject. RESULTS: A total of 120 participants were randomised between the two teaching groups (60 subjects in each group). Mean time to LMA insertion at acquisition was 39.7 s for 2-stage and 34.7 s for 4-stage (p>0.05), and proportion completing within 30 s was 41.67% for 2-stage and 48.33% for the 4-stage teaching group (p>0.05). With skill retention assessment, mean time to LMA insertion was 44.3 s for 2-stage and 42.5 s for the 4-stage teaching group (p>0.05). Proportion completing task within 30 s was 34.0% for 2-stage and 41.67% for 4-stage group (p>0.05). Overall, there was no significant difference found in skill acquisition or in skill retention between the 2 or 4-stage teaching method. CONCLUSION: The 2-stage teaching technique is not statistically different to the 4-stage teaching method in efficacy of LMA insertion skill acquisition or retention.

Plasma phospholipase A2 activity in patients with asthma: association with body mass index and cholesterol concentration.

BACKGROUND: Secretory phospholipases A2 (sPLA2) have functions relevant to asthmatic inflammation, including eicosanoid synthesis and effects on dendritic cells and T cells. The aim of this study was to measure sPLA2 activity in patients with stable and acute asthma and to assess potential associations with body mass index (BMI), and plasma cholesterol and vitamin C concentrations. METHODS: Plasma sPLA2 activity and concentrations of cholesterol and vitamin C were measured in 23 control subjects and 61 subjects with stable asthma (42 mild to moderate, 19 severe). In addition, sPLA2 activity was measured in 36 patients experiencing acute asthma and in 22 of these patients after recovery from the acute attack. RESULTS: sPLA2 activity was not significantly greater in severe (499.9 U; 95% confidence interval (CI) 439.4 to 560.4) compared with mild to moderate asthmatic subjects (464.8; 95% CI 425.3 to 504.3) or control subjects (445.7; 95% CI 392.1 to 499.4), although it was higher in patients with acute asthma (581.6; 95% CI 541.2 to 622.0; p<0.001). Male gender, high plasma cholesterol, increased BMI and atopy were associated with increased sPLA2 activity, while plasma vitamin C was inversely correlated with sPLA2 activity in patients with stable asthma and in control subjects. There were significant interactions between gender and plasma cholesterol and between gender and vitamin C in relation to sPLA2 activity. CONCLUSIONS: Plasma sPLA2 may provide a biological link between asthma, inflammation, increased BMI, lipid metabolism and antioxidants. Interactions among these factors may be pertinent to the pathophysiology and increasing prevalence of both asthma and obesity.

The bacteriology of pneumonia diagnosed in Western Australian emergency departments.

We used Western Australian emergency department data linked to hospital morbidity, death and microbiology data to describe the bacteriology of pneumonia according to age. The 'atypical' organisms and viruses were not assessed. A total of 6908 patients over a 3-year period were given an emergency department diagnosis of pneumonia, 76.9% were admitted and 6.3% died in hospital. Blood was cultured from 52.9% of patients with 6.4% growing potential pathogens. Streptococcus pneumoniae was the most common organism isolated and accounted for 92% of pathogens in those aged <15 years. Isolation of Enterobacteriaceae species tended to increase with age and accounted for around 25% of isolates from the elderly. Sputum was cultured from 25.3% of patients and bacteria were isolated from 30.3% of samples, commonly Haemophilus influenzae and S. pneumoniae. Isolates from sputum showed no distinct trend across age groups. These patterns question the value of routine blood and sputum cultures and have implications for empiric therapy for the elderly.

Qualitative evaluation of a formal bedside clinical teaching programme in an emergency department.

BACKGROUND: Bedside clinical teaching in emergency departments is usually opportunist or ad hoc. A structured bedside clinical teaching programme was implemented, where a consultant and registrar were formally allocated to teaching and learning roles separated from the usual departmental management or clinical roles. Themes emphasised included clinical reasoning, practical clinical knowledge, communication, physical examination, procedural and professional skills. AIM: To evaluate the perceived educational value, effects on patient care and areas for ongoing development. METHODS: The study setting was an urban, tertiary referral, university-affiliated emergency department with prospectively allocated educational shifts of 4 or 5 h duration over a 6-month period. Evaluation was by session and course evaluation questionnaires, with respondents ranking predetermined themes and giving free-text responses. Qualitative presentation of results allowed exploration of the themes identified. RESULTS: Learners ranked history taking and physical examination technique as the most frequently learnt item, but clinical reasoning as the most important theme learnt. Informal discussion and performance critique or constructive feedback were the most frequent teaching methods. The biggest obstacle to learning was learner apprehension. The most frequent positive effect on patient care was faster management, decision making or disposition. Most often, no negative effect on patient care was identified. CONCLUSION: Formal bedside teaching is effective if organised with adequate staffing to quarantine the teacher and learner from routine clinical duties, and concentrating on themes best taught in the patient setting. Clinical reasoning and clinical knowledge were perceived to be most important, with positive effects on patient care through more thorough assessment and faster decision making.

The effect of adjunctive fresh frozen plasma administration on coagulation parameters and survival in a canine model of antivenom-treated brown snake envenoming.

This study aimed to assess the effects of dugite envenoming on blood coagulation and platelet count in a canine model, and the efficacy of fresh frozen plasma (FFP) in reversing the clotting disorder after both adequate and inadequate venom neutralization. Following initial dosing and administration studies, an intravenous venom dose of 1 microg/kg was administered to eleven dogs. This was followed 30 minutes later by antivenom in either adequate or inadequate doses. A further 30 minutes later, the animals were given either two units of their own FFP or saline. Fibrinogen, aPTT and platelet levels were monitored for eight hours. Of the six study dogs given antivenom plus FFP, two died at around 60 to 90 minutes post envenoming, at the end of the FFP infusions, and all but one of the survivors had persistent afibrinogenaemia. Of the five study dogs given antivenom and no FFP, all but one had return of detectable fibrinogen at eight hours after envenoming. The platelet count fell in all animals with recovery independent of antivenom dose, administration of FFP, or regeneration of fibrinogen. Post mortem examinations of dogs that died during dosage and administration studies showed massive intracardiac clots. We conclude that early death from Brown Snake envenoming may be due to massive intravascular clotting. FFP administration was associated with persistent afibrinogenaemia regardless of antivenom dose. In the absence of any evidence for its efficacy, this study suggests that the role of FFP after Brown Snake envenoming should be reconsidered.

Implementation and evaluation of an undergraduate emergency medicine curriculum.

OBJECTIVE: To describe the implementation and evaluation of an undergraduate course in the first Australian academic emergency medicine unit. METHODS: A descriptive study of a course involving fifth year medical students at the University of Western Australia was undertaken. Teaching included self-directed case problem solving, small group tutorials, practical-skills teaching, clinical attachments and information handouts. Evaluation involved questionnaire scores and written feedback regarding life-support skills, tutorial teaching, course materials, clinical attachments and the course in general. Some groups of students underwent pre-course and post-course examinations. RESULTS: Subjective and objective testing showed that student knowledge significantly improved. Feedback was especially positive toward clinical attachments in emergency departments, practical skills tutorials and the case-based learning method. Students requested longer attachments to emergency departments, and more practical, case-based, interactive and bedside teaching. Problems encountered included inadequate time for teaching, vagueness about student roles and objectives, and dealing with death for the first time without adequate preparation. CONCLUSION: Undergraduate emergency medicine education should become an essential part of Australian and international undergraduate medical education. Emergency medicine is enjoyable and eminently suitable for problem-based, interactive and integrated teaching and improves confidence, clinical experience in emergencies, practical skills and teamwork. Improvements include more problem-based teaching, more practical skills sessions and better definition of student roles. These are general principles that can be applied to other undergraduate courses and to designers of other emergency medicine courses, both undergraduate and postgraduate.

Sadomasochistic relating: what's sex got to do with it?

The sexuality in sadomasochistic relating is most often viewed as defensive, functioning to erotize the repetition of earlier trauma, as a defense against painful affect, or as masking early, nonerotic needs for recognition and autonomy. However, this emphasis on the nonerotic dimension of so-called sexualized experience leads to symbolic interpretations of sexuality; this "deliteralization of sexuality" requires some embodiment in the concrete and literal, or metaphor is delinked from that which it is derived. Without discounting the validity of such formulations, this paper aims to put the drive (libido) back into formulations of sadomasochistic relations, and discusses the erotic dimension in sadomasochistic relations as an irreducible, hidden structure that both threatens and sustains the destructive attachment. It is suggested that sexuality is a driving force behind sadomasochistic interplay, while aggression may be recruited for defensive, concealing purposes. Through a case illustration, this paper demonstrates how sadomasochistic relating is symbolically penetrating, teasing, withholding, and intensifying in hate-inducing ways, all of which are designed to gratify and simultaneously harden the other. In many cases, sadomasochistic sexuality may be viewed as aggressivized, paradoxically, to maintain safety under the regressive pull of sexual and preoedipal longings.

Personality characteristics of mental health professionals who have engaged in sexualized dual relationships: a Rorschach investigation.

This study is the first to empirically investigate the psychological characteristics of mental health professionals who have engaged in sexualized dual relationships. Twenty mental health professionals were administered the Rorschach as part of a comprehensive evaluation to assess rehabilitation potential during or after a disciplinary hearing. The Rorschach protocols were scored according to Exner's (1993) Comprehensive System. Results included a total of seven scores that differed by more than 3 standard deviations from the normative mean. These included measures of distress (especially interpersonal longing, helplessness, and generalized dysphoria), primitive sexualization, and idiosyncratic reality contact. Other indicators differing by 2 standard deviations from the normative mean included measures of vulnerable self-boundaries and long-standing, characterological dysphoria. These characteristics and vulnerabilities are consistent with previous observations emphasizing long-standing conflicts involving interpersonal longing and deprivation, anxiety regarding body integrity or self-boundaries, primitive sexualization of anxiety-provoking issues, and depression (Celenza, 1995b). Awareness of such vulnerabilities may represent useful guidelines to supervisors and educators as a focus of concern in an individual's training and personal development.

Thunderstorm associated asthma: a detailed analysis of environmental factors.

OBJECTIVES: To seek associations between meteorological factors, concentrations of air pollutants or pollen, and an asthma epidemic which occurred in London on 24 and 25 June 1994 after a thunderstorm. DESIGN: Retrospective study of patients' accident and emergency department records, with bivariate and multivariate analysis of environmental factors and data collection for the two months surrounding the epidemic. SETTING: The accident and emergency department of St Mary's Hospital in west central London. SUBJECTS: 148 patients presenting with asthma between 1 June and 31 July 1994, of whom 40 presented in the 24 hours after the storm. RESULTS: The asthma epidemic was significantly associated with a drop in air temperature six hours previously and a high grass pollen concentration nine hours previously. Non-epidemic asthma was significantly associated with lightning strikes, increase in humidity or sulphur dioxide concentration, a drop in temperature or high rainfall the previous day, and a decrease in maximum air pressure or changes in grass pollen counts over the previous two days. CONCLUSIONS: New episodes of asthma during the epidemic on 24 and 25 June 1994 were associated with a fall in air temperature and a rise in grass pollen concentration. Non-epidemic asthma was significantly associated with a greater number of environmental changes. This may indicate that the patients with thunderstorm associated asthma were a separate population, sensitive to different environmental stimuli.

[Epidemiology, prevention and therapy of diseases caused by viruses of the Herpesviridae family]. / Epidemiologia, profilassi e terapia delle malattie da virus della famiglia herpesviridae.

The epidemiology and prophylaxis of the commonest diseases induced by herpesviruses are described. Clinical and therapeutical aspects are briefly reviewed.