Evaluation of IL-8 nasal lavage levels and the effects of nasal involvement on disease severity in patients with stable chronic obstructive pulmonary disease.

Interleukin 8 (IL-8) is used to evaluate the severity of inflammation in the airways. The aim of this study was to evaluate patients with chronic obstructive pulmonary disease (COPD) for the presence of upper respiratory tract involvement by questioning patients regarding nasal symptoms and by measuring levels of IL-8 in nasal lavage material. A total of 47 COPD patients and 23 healthy controls were enrolled in this study. Pulmonary function tests were performed for all participants who were asked to complete a Sinonasal Outcome Test-20 (SNOT-20) questionnaire on the same day, as a measure of quality of life. Median IL-8 level in nasal lavage specimens of COPD patients with stable disease was higher than that of healthy controls. An increase in cigarette pack-years was significantly associated with an increase in nasal IL-8 levels. Similarly, IL-8 levels correlated positively with stage of COPD. A significant link between number of visits to the emergency department and stage of disease was observed. Patients with COPD had a significantly higher mean SNOT-20 severity score compared to healthy controls. Proper management of sinonasal disease may help to decrease the number of COPD attacks and consequently improve quality of life.

Thyroid hormone levels as a predictor of mortality in intensive care patients: A comparative prospective study.

BACKGROUND: Mortality rates of intensive care patients are quite high. The aim of this study was to determine the role, as well as to compare the value of several markers in predicting mortality in intensive care patients. Patient-wise, this is the largest study of its kind and the first that attempts to correlate the degree of thyroid hormone suppression with elevations in procalcitonin (PCT) levels. PATIENTS AND METHODS: In this study, a total of 417 patients were included in the final analysis, 235 of which were men (56%), and 182 were women (44%). Predictors of mortality that were investigated include age, APACHE II score, PCT, free triiodo-L-thyronine (fT3), free tetraiodothyronine/thyroxine (fT4) and thyroid stimulating hormone/thyrotropin (TSH). RESULTS: High APACHE II score and low PCT levels, as well as suppression of fT3, fT4 and TSH levels were all found to be associated with higher mortality in our intensive care patients (p < 0.001). Suppression of thyroid hormones was also found to be reciprocally correlated with high APACHE II scores and PCT levels (p < 0.05). CONCLUSION: Calculation of APACHE II score as well as measurement of PCT, fT3, fT4 and TSH levels may all be useful as predictors of mortality in intensive care patients.

El curso endoscópico de manchas blancas dispersas en la porción descendente del duodeno: un estudio prospectivo / The endoscopic course of scattered white spots in the descending duodenum: A prospective study

Objetivo Las manchas blancas dispersas (MBD) en la porción descendente del duodeno son un hallazgo poco frecuente en la endoscopia del sistema digestivo superior (ESDS). Las MBD se han asociado con linfangiectasia intestinal, duodenitis crónica inespecífica y giardiasis. El objetivo de este estudio fue determinar la frecuencia de hallazgos de MBD en endoscopias rutinarias, así como evaluar el efecto del tratamiento de dicho hallazgo. Material y métodos Se incluyeron de forma prospectiva a pacientes sometidos a ESDS con MBD en el duodeno. La apariencia de las MBD se clasificó mediante endoscopia, de acuerdo con la densidad, después de dividir a los pacientes en dos grupos: grupo 1 (grupo tratado) y grupo 2 (grupo sin tratar). Los pacientes con infección por Helicobacter pylori recibieron un tratamiento de erradicación, mientras que a los pacientes con linfangiectasia intestinal se les recomendó una dieta. Los pacientes con gastritis y negativos en H. pylori iniciaron un tratamiento con inhibidores de la bomba de protones. Todos los pacientes volvieron a ser evaluados 3 meses después del inicio del tratamiento para detectar cambios en la presencia de MBD. Resultados se observaron MBD en 97 pacientes (3,2%) de los 3.010 incluidos en el estudio. Las MBD se asociaron más comúnmente con duodenitis crónica inespecíficas, seguida de linfangiectasia intestinal. En el grupo sin tratamiento, no se observaron cambios estadísticamente significativos en el aspecto de la MDB, pero se observó una disminución estadísticamente significativa de la densidad en el grupo tratado (p<0,001). Conclusión La prevalencia de MBD durante ESDS rutinaria fue del 3,2%. Este hallazgo se asoció más frecuentemente con duodenitis crónica inespecífica y linfangiectasia intestinal. El tratamiento de las causas subyacentes, entre ellas la erradicación de H. pylori, los inhibidores de la bomba de protones y la dieta, disminuyeron la densidad de ESDS (AU)

Aim Scattered white spots (SWSs) in the descending duodenum are an uncommon finding of upper gastrointestinal system endoscopy (UGSE). Intestinal lymphangiectasia, chronic nonspecific duodenitis and giardiasis are associated with a SWS appearance. The aim of this study was to determine the frequency of SWS during routine endoscopy, as well as to evaluate the effect of treatment on this finding. Materials and methods Patients undergoing UGSE with a SWS appearance in the descending duodenum were included prospectively. Appearance of SWSs was graded endoscopically based on density, after which patients were divided into two groups; group 1 (treated group) and group 2 (untreated group). Patients with Helicobacter pylori infection were given eradication therapy, whereas a diet was recommended to patients with intestinal lymphangiectasia. Proton pump inhibitors were initiated for patients with H. pylori negative gastritis. All patients were re-evaluated three months after therapy for the presence of any changes in the SWS appearance. Results SWSs were observed in 97 (3.2%) out of 3010 patients. This appearance was most commonly associated with chronic non-specific duodenitis followed by intestinal lymphangiectasia. While in the untreated group no statistically significant change in SWS appearance was observed, the decrease in endoscopic grade seen in the treated group was statistically significant (p<0.001).Conclusion The prevalence of SWSs during routine UGSE was 3.2%, with this finding being more commonly associated with chronic non-specific duodenitis and intestinal lymphangiectasia. Treatment of the underlying causes, including H. pylori eradication, proton pump inhibitors and diet decreased the density of the SWS (AU)

The endoscopic course of scattered white spots in the descending duodenum: a prospective study.

AIM: Scattered white spots (SWSs) in the descending duodenum are an uncommon finding of upper gastrointestinal system endoscopy (UGSE). Intestinal lymphangiectasia, chronic nonspecific duodenitis and giardiasis are associated with a SWS appearance. The aim of this study was to determine the frequency of SWS during routine endoscopy, as well as to evaluate the effect of treatment on this finding. MATERIALS AND METHODS: Patients undergoing UGSE with a SWS appearance in the descending duodenum were included prospectively. Appearance of SWSs was graded endoscopically based on density, after which patients were divided into two groups; group 1 (treated group) and group 2 (untreated group). Patients with Helicobacter pylori infection were given eradication therapy, whereas a diet was recommended to patients with intestinal lymphangiectasia. Proton pump inhibitors were initiated for patients with H. pylori negative gastritis. All patients were re-evaluated three months after therapy for the presence of any changes in the SWS appearance. RESULTS: SWSs were observed in 97 (3.2%) out of 3010 patients. This appearance was most commonly associated with chronic non-specific duodenitis followed by intestinal lymphangiectasia. While in the untreated group no statistically significant change in SWS appearance was observed, the decrease in endoscopic grade seen in the treated group was statistically significant (p<0.001). CONCLUSION: The prevalence of SWSs during routine UGSE was 3.2%, with this finding being more commonly associated with chronic non-specific duodenitis and intestinal lymphangiectasia. Treatment of the underlying causes, including H. pylori eradication, proton pump inhibitors and diet decreased the density of the SWSs.

Thyroid hormone levels predict mortality in intensive care patients with cirrhosis.

INTRODUCTION: Mortality rates of intensive care patients are quite high. The aim of this study was to determine the availability of thyroid function tests and predictive scoring systems on the outcome of cirrhotic patients admitted to the intensive care unit. METHODS: A total of 106 patients were included in the final analysis, of which 32 were men (30.2%) and 74 were women (69.8%). Predictors of mortality that were investigated include acute physiology and chronic health evaluation (APACHE II), model for end-stage liver disease (MELD), Child-Turcotte-Pugh (CTP) and sequential organ failure assessment (SOFA) scores and thyroid function tests including free triiodo-L-thryronin (fT3), free tetraiodothyronine/thyroxine (fT4) and thyroid-stimulating hormone/thyrotropin (TSH) levels. RESULTS: High APACHE II, MELD, CTP and SOFA score and suppression of fT3 were all found to be associated with higher mortality in our intensive care patients who have cirrhosis (P < 0.001). Suppression of fT3 was also found to be reciprocally correlated with high APACHE II, MELD, CTP and SOFA scores (P < 0.001). fT4 had also reciprocal correlation with APACHE II, MELD, CTP and mortality. There is no correlation between TSH levels and predictive scores or mortality. CONCLUSIONS: Calculation of APACHE II, MELD, CTP and SOFA scores and measurement of fT3 and fT4 levels may all be useful as predictors of mortality in intensive care patients who have cirrhosis.