ABSTRACT
Prospective studies on 347 children under treatment due to seizures which appeared in the first 10 years of life helped to evaluate and define the incidence of epilepsy resistant to treatment. With regard to each patient the following aspects were analysed: the kind of seizures, their etiology, accompanying neurological disorders and a type of epileptic syndrome, kind of treatment applied before admission to the clinical department as well as socioeconomic conditions of the families. Patients under study were divided into four age groups to evaluate the results. Epilepsy, which was completely resistant to treatment, was observed in 10% of the patients, partially resistant in 20%. Resistance is the outcome of the following factors: onset of epilepsy in early childhood, symptomatic etiology coexisting symptoms of CNS damage, occurrence of unfavourable epileptic syndromes such as Lennox-Gastaut, wrong selection and low dosage of drugs, inappropriate polytherapy and adverse social conditions. On the basis of the results obtained, the authors suggested point evaluation as a kind of screening in prediction of failures in treatment.
Subject(s)
Epilepsy/therapy , Age of Onset , Child , Child, Preschool , Female , Humans , Infant , Male , Prospective Studies , Treatment OutcomeABSTRACT
The authors describe the clinical manifestations of the little known neurodermal syndrome described in 1952 by Ito and called Ito's hypomelanosis. Two own cases are presented.
Subject(s)
Epilepsies, Myoclonic/diagnosis , Pigmentation Disorders/diagnosis , Child , Child, Preschool , Diagnosis, Differential , Epilepsies, Myoclonic/complications , Female , Humans , Incontinentia Pigmenti/diagnosis , Infant , Male , Pigmentation Disorders/complications , SyndromeABSTRACT
Tuberous sclerosis belongs to the diseases diagnosed usually at pre-school or school age. Pringle's naevus ist the basic sing indicating the diagnosis. Genetic determination of the disease makes possibly early diagnosis necessary for correct genetic counselling. In the light of long-term observations of children with tuberous sclerosis the authors discuss the problems connected with early diagnosis of this condition evaluating the diagnostic usefulness of various signs and symptoms of the disease, and the usefulness of radiological examination methods. The importance of computer tomography for early diagnosis, and of family examination in cases of tuberous sclerosis is emphasized.