ABSTRACT
OBJECTIVES: This study aimed to explore the effects of curcumin on experimental allergic rhinitis in rats. METHODS: Twenty-eight male Wistar albino rats were randomly divided into four groups: a control group; a group in which allergic rhinitis was induced and no treatment given; a group in which allergic rhinitis was induced followed by treatment with azelastine hydrochloride on days 21-28; and a group in which allergic rhinitis was induced followed by treatment with curcumin on days 21-28. Allergy symptoms and histopathological features of the nasal mucosa were examined. RESULTS: The sneezing and nasal congestion scores were higher in the azelastine and curcumin treatment groups than in the control group. Histopathological examination showed focal goblet cell metaplasia on the epithelial surface in the azelastine group. In the curcumin group, there was a decrease in goblet cell metaplasia in the epithelium, decreased inflammatory cell infiltration and vascular proliferation in the lamina propria. CONCLUSION: Curcumin is an effective treatment for experimentally induced allergic rhinitis in rats.
Subject(s)
Anti-Allergic Agents/pharmacology , Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Curcumin/pharmacology , Goblet Cells/drug effects , Nasal Mucosa/drug effects , Phthalazines/pharmacology , Rhinitis, Allergic/pathology , Sneezing/drug effects , Administration, Intranasal , Animals , Chondrocytes/drug effects , Chondrocytes/pathology , Cilia/drug effects , Cilia/pathology , Eosinophils/drug effects , Goblet Cells/pathology , Hyperemia , Hypertrophy , Male , Mast Cells/drug effects , Metaplasia , Nasal Mucosa/pathology , Ovalbumin/adverse effects , Random Allocation , Rats , Rats, WistarABSTRACT
OBJECTIVE: Suture granuloma, the rare complication of thyroidectomy, results from the use of nonabsorbable suture materials. Despite its typical ultrasound images and benign course, it carries utmost importance in the diff erential diagnosis of lymph nodes, recurrent nodules, and recurrence in the case of thyroid cancers. Subject and Results. Fifty four years old female patient, who underwent bilateral thyroidectomy in July 2010, was diagnosed with multinodular goiter and incidentally discovered micropapillary carcinoma (2 mm). Four years later, she was readmitted to hospital due to painless swelling in the right and left anterior neck region. Ultrasonography revealed nodules with irregular boundaries, containing micro- and macro-calcifications and hyperechoic lines in both sides of the thyroid bed and isthmus. Fine needle aspiration biopsy was performed in the right and left sided mass and the cytological examination was compatible with the diagnosis of the suture granuloma. CONCLUSIONS: Suture granuloma should be considered in the differential diagnosis of the local recurrence.
Subject(s)
Granuloma, Foreign-Body/etiology , Suture Techniques/adverse effects , Suture Techniques/instrumentation , Sutures/adverse effects , Thyroidectomy/adverse effects , Biopsy, Fine-Needle , Diagnosis, Differential , Female , Granuloma, Foreign-Body/diagnostic imaging , Granuloma, Foreign-Body/pathology , Humans , Middle Aged , Predictive Value of Tests , Treatment Outcome , UltrasonographyABSTRACT
Melanoma is the most serious form of skin cancers and life-time risk of melanoma is increasing rapidly both in men and women. Melanoma in the parotid gland is seen rarely and it is more likely to be metastatic disease. We present here a rare case of metastatic malignant melanoma from the forehead skin to the parotid glands bilaterally.
