ABSTRACT
The findings on the effect of thyroid hormones on the metabolism of the vascular wall are presented. In 231 subjects with hyper- and hypofunction of the thyroid gland the arterial pulse propagation time (APPT) and the APPT index (APPT I) were examined as indirect indicators of arterial extensibility. Age-dependent reduction of APPT and APPT I was found in euthyroid subjects as well as hyper- and hypothyroid patients. In younger subjects aged 20--39 years the APPT interval was shorter in thyrotoxicosis and longer in hypothyroidism. The authors discuss the role of changes in the rate of blood flow and changes of the arterial media in the interpretation of these findings. The index of the left ventricular ejection time (LVET I) does not change with age in any of the examined groups. Changes of the arterial wall in higher age groups in man manifested by shortening of APPT were not influenced by increased or reduced thyroid function.
Subject(s)
Hyperthyroidism/physiopathology , Hypothyroidism/physiopathology , Thyroid Hormones/blood , Vascular Resistance , Adolescent , Adult , Aged , Arteries/physiopathology , Blood Flow Velocity , Elasticity , Electrocardiography , Female , Hemodynamics , Humans , Male , Middle AgedABSTRACT
Differences in the frequency rates of seven signs determined by locus HLA-A and of 14 signs controlled by the HLA-B locus and also differences in the rates of appearance of four signs of the Gm system and that of the Inv(1) sign were searched for between patients suffering from diseases of the thyroid gland and healthy subjects. No statistically significant differences in the HLA system could be demonstrated when healthy subjects were compared to the diseased patients. In simple goiter patients there was a significant difference in the frequency rates of the Gm (1, 4, 5) phenotypes and a highly significant difference in the frequency rates of the Gm (1, 2, 4, 5) phenotypes. No direct association could be demonstrated between the above mentioned systems and the studied disease.
Subject(s)
Gangliosides/genetics , Goiter/genetics , Graves Disease/genetics , HLA Antigens/genetics , Hyperthyroidism/genetics , Phenotype , Chromosome Mapping , Gene Frequency , HLA-B Antigens , HumansSubject(s)
Aging , Cardiomyopathies/etiology , Hyperthyroidism/complications , Myocardial Contraction , Systole , Adult , Aged , Cardiomyopathies/diagnosis , Electrocardiography , Female , Heart Rate , Humans , Male , Middle AgedABSTRACT
The relationship between the ejection time from the left ventricle (LVET), the pre-ejection period (PEP) of the left ventricle, the Q-Kd interval, the course of the Achilles tendon reflex (ATR) and the thyroxine (T4) and triiodothyronine (T3) serum level in 184 patients with different grades of thyroid function was investigated. Some of these patients suffered from cardiac affection caused by thyrotoxicosis or ischemic heart disease. The significant inverse correlations between the T3 level and the duration of PEP, LVET, the Q-Kd interval and the ATR was revealed. An inverse relationship with T4 level was found only in the Q-Kd interval and ATR. In those instances, where there was a correlation with T4 and T3, higher values of correlation coefficients were observed in the correlation with T3. T4 concentration was higher in patients with cardiac affection. In thyrocardiacs was an increase in the quotient T4:T3, while in thyrotoxic patients without cardiac affection this quotient was rather decreased. The significance of disturbed T4 metabolism in development of cardiac affection in thyrotoxicosis is discussed with respect to ageing processes.
