1.
ChemSusChem
; 16(15): e202300086, 2023 Aug 07.
Article
in English
| MEDLINE
| ID: mdl-36971384
ABSTRACT
A scalable and operationally simple on water seleno-mediated reduction of nitroarenes to the respective aryl amines with NaBH4 is described. The reaction proceeds under transition metal-free conditions and is promoted by the formation of Na2 Se, which is the effective reducing agent involved in the mechanism. This mechanistic information enabled the development of a mild NaBH4 -free protocol for the selective reduction of nitro derivatives bearing labile moieties, including nitrocarbonyl compounds. The selenium-containing aqueous phase can be successfully reused up to four reduction cycles, thus further improving the efficiency of the protocol disclosed.