ABSTRACT
Background: The aim of this research was to characterise the interest on the most frequent cancers in Peru through Google Trends, its geographic and temporal relationship with massive awareness campaigns. Methods: A temporal trends analysis for the last 5 years was carried out, comparing the Relative Search Volume (RSV) with the dates of mass cancer awareness campaigns in Peru. Google Trends application was used to evaluate the interest in the topics: breast, prostate, cervical stomach and colorectal cancer between 1 January 2016 and 31 December 2020, expressed in RSV. The annual RSV for each neoplasm was compared, as well as its annual variation using the Kruskal-Wallis test. The correlation between the RSV and the estimated incidence for each province was measured using the Spearman test. Results: The topics with the highest RSV were breast (median: 20, range: 6-100) and prostate cancer (median: 28, range: 9-48). The topic 'breast cancer' showed a cyclical punctual increase in October, its awareness month. Searches for cervical, stomach and colorectal cancer were smaller and did not show peaks of interest. It was observed that the RSV was variable when compared with previous years (p < 0.05 for all the evaluated topics). Geographically, different provincial configurations of interest were observed according to neoplasia. When correlating the RSV with the incidence by province, a non-significant positive correlation (p > 0.05) was found for breast, cervical and colorectal cancer. Conclusions: This study suggests a positive temporal correlation between RSV and awareness cancer campaigns in Peru specially to breast cancer and, to a lesser extent, prostate cancer. Significant variations of interest were demonstrated for each neoplasm among the evaluated years. No significant correlation was found between the incidence rate and the average RSV among Peruvian provinces.
ABSTRACT
Ewing sarcoma is a rare and highly aggressive neoplasm that occurs most frequently in male adolescents. The incorporation of neoadjuvant therapy and new surgical techniques has improved survival. We present the case of a 41-year-old man diagnosed with Ewing sarcoma of the chest wall, whose tumor showed a pathological complete response to a multimodal treatment consisting of concurrent chemotherapy, radiotherapy, and surgical resection. Ewing sarcoma rarely occurs in adults, who generally have a worse prognosis. A multimodal approach for the treatment of patients older than 40 years has proven to improve oncological results.
El sarcoma de Ewing es una neoplasia rara y altamente agresiva que afecta con cierta predilección adolescentes varones. La incorporación de terapia neoadyuvante y nuevas técnicas quirúrgicas ha mejorado la supervivencia. Presentamos el caso de un varón de 41 años con sarcoma de Ewing de pared torácica, quien recibió tratamiento multimodal consistente en quimio-radioterapia concurrente y tratamiento quirúrgico, y alcanzó respuesta patológica completa. El sarcoma de Ewing rara vez se presenta en la edad adulta y, cuando lo hace, suele tener mal pronóstico. El tratamiento multimodal de pacientes mayores de 40 años ha probado mejorar los resultados oncológicos.
Subject(s)
Sarcoma, Ewing , Adult , Combined Modality Therapy , Humans , Male , Neoadjuvant Therapy , Sarcoma, Ewing/diagnostic imaging , Sarcoma, Ewing/therapyABSTRACT
Resumen El sarcoma de Ewing es una neoplasia rara y altamente agresiva que afecta con cierta predilección adolescentes varones. La incorporación de terapia neoadyuvante y nuevas técnicas quirúrgicas ha mejorado la supervivencia. Presentamos el caso de un varón de 41 años con sarcoma de Ewing de pared torácica, quien recibió tratamiento multimodal consistente en quimio-radioterapia concurrente y tratamiento qui rúrgico, y alcanzó respuesta patológica completa. El sarcoma de Ewing rara vez se presenta en la edad adulta y, cuando lo hace, suele tener mal pronóstico. El tratamiento multimodal de pacientes mayores de 40 años ha probado mejorar los resultados oncológicos.
Abstract Ewing sarcoma is a rare and highly aggressive neoplasm that occurs most frequently in male adolescents. The incorporation of neoadjuvant therapy and new surgical techniques has improved survival. We present the case of a 41-year-old man diagnosed with Ewing sarcoma of the chest wall, whose tumor showed a pathological complete response to a multimodal treatment consisting of concurrent chemotherapy, radiotherapy, and surgical resection. Ewing sarcoma rarely occurs in adults, who generally have a worse prognosis. A multimodal approach for the treatment of patients older than 40 years has proven to improve oncological results.
Subject(s)
Humans , Male , Adult , Sarcoma, Ewing/therapy , Sarcoma, Ewing/diagnostic imaging , Combined Modality Therapy , Neoadjuvant TherapyABSTRACT
Liposarcomas are malignant mesenchymal tumours usually located in the retroperitoneum, rarely occurring as a single lesion in the kidney. We present a case of a 59-year-old male patient with a left renal mass detected by computed tomography scan. He underwent radical nephrectomy and the histopathological study reported a primary undifferentiated liposarcoma of the kidney without nodal involvement. After 15 months of surgery, he remained asymptomatic and without evidence of disease recurrence. The objective of this report is to present a case and literature review with current evidence of treatment options and prognostic factors for survival.
ABSTRACT
OBJECTIVES: To evaluate the preventive effect of Sacha Inchi oil (SIO) on 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis (CC) in Holtzman rats. MATERIALS AND METHODS: Experimental study with 28 Holtzman male albino rats randomly distributed into 4 groups: a positive control group exposed to DMH (C1), a negative control group exposed to SIO at 150 uL/kg/day (C2), and two experimental groups exposed to DMH with SIO at 150 uL/kg/day (E1) and SIO at 300 uL/kg/day (E2). The DMH was applied for 8 weeks and the total induction time was 22 weeks. Pathological examination was performed by identifying cancerous tumor lesions in the guts. The preventive effect was evaluated based on proportions of lack of lesion in the groups exposed to DMH. RESULTS: Cancerous tumor lesions were identified in: two specimens of group C1, one specimen of group E1 and two specimens of group E2. No intestinal lesions were identified in group C2. The proportions of lack of lesion were: in group C1 of 75%, in group E1 of 87.5% and group E2 of 75%. No significant differences were found (p>0.05). CONCLUSIONS: It was not found a significant protective effect of SIO on DMH-induced CC in Holtzman rats, compared to control group.
Subject(s)
Adenocarcinoma/prevention & control , Colonic Neoplasms/prevention & control , Euphorbiaceae , Phytotherapy , Plant Oils/therapeutic use , 1,2-Dimethylhydrazine , Adenocarcinoma/chemically induced , Adenocarcinoma/pathology , Animals , Colonic Neoplasms/chemically induced , Colonic Neoplasms/pathology , Male , Random Allocation , Rats , Rats, Sprague-Dawley , Treatment OutcomeABSTRACT
Objetivos: Evaluar el efecto protector del aceite de Sacha Inchi (ASI) sobre el desarrollo de cáncer de colon (CC) inducido con 1,2dimetilhidrazina (DMH) en ratas Holtzman. Materiales y métodos: Estudio experimental con 28 ratas albinas machos de la cepa Holtzman distribuidas al azar en 4 grupos: un grupo control positivo expuesto a DMH (C1), un grupo control negativo expuesto a ASI a 150 μL/kg/día (C2), y dos grupos experimentales expuestos a DMH con ASI a 150 μL/kg/día (E1) y ASI a 300 μL/kg/día (E2). La DMH se aplicó por 8 semanas y con un tiempo total de inducción de 22 semanas. Luego se realizó el análisis patológico mediante la identificación de lesiones tumorales cancerosas en los intestinos. El efecto protector se evaluó en base a las proporciones de ausencia de lesión en los grupos expuestos a DMH. Resultados: Se identificaron lesiones tumorales cancerosas en: dos especímenes del grupo C1, un espécimen del grupo E1 y dos especímenes del grupo E2. No se identificaron lesiones intestinales en el grupo C2. Las proporciones de ausencia de lesión fueron: en el grupo C1 de 75%, en el grupo E1 de 87,5% y en el grupo E2 de 75%. No se encontraron diferencias significativas (p>0,05). Conclusiones: No se evidenció un efecto protector significativo del ASI sobre el desarrollo de CC inducido con DMH en ratas Holtzman, respecto al grupo control.
Objectives: To evaluate the preventive effect of Sacha Inchi oil (SIO) on 1,2dimethylhydrazine (DMH)-induced colon carcinogenesis (CC) in Holtzman rats. Materials and methods: Experimental study with 28 Holtzman male albino rats randomly distributed into 4 groups: a positive control group exposed to DMH (C1), a negative control group exposed to SIO at 150 uL/kg/ day (C2), and two experimental groups exposed to DMH with SIO at 150 uL/kg/day (E1) and SIO at 300 uL/kg/day (E2). The DMH was applied for 8 weeks and the total induction time was 22 weeks. Pathological examination was performed by identifying cancerous tumor lesions in the guts. The preventive effect was evaluated based on proportions of lack of lesion in the groups exposed to DMH. Results: Cancerous tumor lesions were identified in: two specimens of group C1, one specimen of group E1 and two specimens of group E2. No intestinal lesions were identified in group C2. The proportions of lack of lesion were: in group C1 of 75%, in group E1 of 87.5% and group E2 of 75%. No significant differences were found (p>0.05). Conclusions: It was not found a significant protective effect of SIO on DMH-induced CC in Holtzman rats, compared to control group.
Subject(s)
Animals , Male , Rats , Plant Oils/therapeutic use , Adenocarcinoma/prevention & control , Colonic Neoplasms/prevention & control , Euphorbiaceae , Phytotherapy , Adenocarcinoma/chemically induced , Adenocarcinoma/pathology , Random Allocation , Treatment Outcome , Rats, Sprague-Dawley , Colonic Neoplasms/chemically induced , Colonic Neoplasms/pathology , 1,2-DimethylhydrazineABSTRACT
La peste es una infección zoonótica causada por la bacteria Yersinia pestis, cuyo último rebrote desde el año 2009 en la región La Libertad ha incrementado la necesidad de reevaluar los factores asociados a su transmisión. Objetivo. Determinar la asociación entre el hacinamiento en viviendas y casos de peste sospechosos registrados en el distrito de Casa Grande, La Libertad, entre los años 2010 y 2012 (CG-LL 2010-12). Material y Método. El tamaño de muestra fue de 11 casos de peste sospechosos registrados en el distrito de CG-LL 2010-12 (Centro de salud Casa Grande, Ministerio de Salud), utilizando una relación caso/control de 1:2 y utilizando un muestreo aleatorio. El hacinamiento en vivienda fue evaluado mediante la revisión de las fichas epidemiológicas en los casos de peste sospechosos y la visita de campo aplicando una encuesta sobre datos de vivienda en los controles. Resultados. Se determinó que el odds ratio del hacinamiento en viviendas fue de 1,41, con un intervalo confianza del 95 %: 1,10 a 5,66 (p < 0,05). Con una frecuencia de hacinamiento de 18,18% en el grupo de casos y 13,63% en el grupo de controles. Conclusión. El hacinamiento en viviendas estuvo asociado 1,41 más veces en los casos de peste sospechosos registrados en el distrito de Casa Grande, La Libertad, entre los años 2010 y 2012, en comparación a la población que no contrajo esta enfermedad...
Plague is a zoonotic infection caused by the bacterium Yersinia pestis, whose recent outbreak since 2009 at La Libertad region has increased the need to reassess the factors associated with transmission. Objective. To determine the association between overcrowded in housing and suspected plague cases registered in the district of Casa Grande, La Libertad between 2010 and 2012 (CG-LL 2010-12). Material and Method. The sample size was 11 suspected cases of plague recorded in the district of CG-LL 2010-12 ("Casa Grande" Health Center, Ministry of Health), using a case / control ratio of 1: 2, using random sampling. Overcrowded in housing was evaluated by reviewing epidemiological records in the suspected cases of plague and through a field trip survey of housing data in the controls. Results. We found that the odds ratio of overcrowded in housing was 1, 41 with a 95 % confidence interval: 1, 10 to 5,66 (p < 0,05). With a overcrowded in housing frequency of 18, 18 % in the cases group and 13, 63 % in the controls group. Conclusion. Overcrowded in housing was associated 1.41 times more in the suspected plague cases registered in the district of Casa Grande, La Libertad between 2010 and 2012, compared to population who did not contract this disease...
