ABSTRACT
alpha-Tocopherol belongs to the group of vitamin E vitamers. Recent years findings indicate that alpha-tocopherol is more than just a simple fat-soluble anti-oxidant as it was found that it can also regulate gene expression. From all vitamin E vitamers human body preferentially retains alpha-tocopherol, but the reasons for this preference are still elusive. Different studies indicated that human body, through the action of two hepatic proteins, alpha-tocopherol transfer protein (alpha-TTP) and cytochrome P450 4F2 (CYP4F2), is able to make subtle structural differences between different vitamin E forms. This is an example of stereochemistry used as a discrimination factor between molecules with different biological activities.
Subject(s)
alpha-Tocopherol/metabolism , Antioxidants/metabolism , Carrier Proteins/metabolism , Cytochrome P-450 Enzyme System/metabolism , Cytochrome P450 Family 4 , Humans , StereoisomerismABSTRACT
Synthesis and chemical and physical characterization of four new complex compounds of thiobenzpyrolidide [1-(pyrolidine)-thiobenzoyl] with Pd(II), Pt(II), Cu(I) and Hg(II) are presented. The purposed chemical structure for these complexes is suggested by the elemental chemical analysis, molecular mass measurements, electric conductivities as well as by UV-VIS and IR spectra. The obtained compounds may in principle be used as enzyme inhibitors having a pronounced insecticidal action.
