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Theor Popul Biol ; 71(3): 332-41, 2007 May.
Article in English | MEDLINE | ID: mdl-17353024

ABSTRACT

Characterizing the spatial variation of allele frequencies in a population has a wide range of applications in population genetics. This article introduces a new nonparametric method, which provides a two-dimensional representation of a structural parameter called the genetical bandwidth, which describes genetic structure around arbitrary spatial locations in a study area. This parameter corresponds to the shortest distance to areas of significant allele variation, and its computation is based on the Womble's systemic function. A simulation study and application to data sets taken from the literature give evidence that the method is particularly demonstrative when the fine-scale structure is stronger than the large-scale structure, and that it is generally able to locate genetic boundaries or clines precisely.


Subject(s)
Chromosome Mapping , Gene Frequency , Genetics, Population , Models, Genetic , Genetic Variation , Genome, Human , Humans , Systems Biology
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