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1.
Int J Immunopathol Pharmacol ; 19(3): 661-74, 2006.
Article in English | MEDLINE | ID: mdl-17026851

ABSTRACT

Employing purified extracellular matrix (ECM) proteins, i.e. type I, III, IV and V collagens (CI, CIII, CIV, CV), laminin (LM) and fibronectin (FN), as antigen sources we detected autoantibodies to conformational and/or denatured ECM antigens among 34 of 50 sera obtained from Hashimotos thyroiditis (HT) patients and 6 of 51 control sera obtained from non-autoimmune thyroid disease patients and healthy donors (HT sera vs. control sera p=4 x 10-9). Reactivity to conformational antigens, mostly due to autoantibodies of the IgG isotype, was observed in 30/50 HT sera and in 6/51 control sera (p=3.5 x 10-7) and was not always concomitant with that to linear antigens, found in 23/50 HT and in 6/51 control sera (p=1.6 x 10-4). Ultrastructural analysis of skin biopsies obtained from 18 HT patients without symptomatic cutaneous diseases revealed defects of the stratified squamous epithelium basement membrane in 11/18, alterations of the stroma in 13/18 and both basement membrane and stromal defects in 9/18. Interestingly, 13/13 (p=0.012) and 9/11 (p=0.012) patients with stromal and basement membrane defects respectively, exhibited serum antibodies to at least one ECM antigen involved in the organization of the altered tissue compartment. Lastly, 10/18 skin biopsies presented immunoglobulin (Ig) and/or complement (C3) deposits along the cutaneous basement membrane zone (BMZ) or in the papillary dermis and 9/10 sera from the same patients simultaneously showed antibodies to at least one ECM antigen involved in the organization of these two skin compartments. Besides, 8/11 HT patients with basement membrane defects exhibited Ig or C3 deposits along the BMZ. Our findings suggest that autoantibodies to ECM molecules might contribute to the development of asymptomatic extra-thyroid skin diseases in HT patients.


Subject(s)
Autoantibodies/blood , Extracellular Matrix Proteins/immunology , Hashimoto Disease/immunology , Skin/ultrastructure , Basement Membrane/ultrastructure , Complement C3/analysis , Enzyme-Linked Immunosorbent Assay , Epithelium/ultrastructure , Hashimoto Disease/pathology , Humans , Immunoglobulin Isotypes/blood , Immunoglobulins/analysis , Stromal Cells/ultrastructure
2.
Psychiatry Res ; 34(2): 139-47, 1990 Nov.
Article in English | MEDLINE | ID: mdl-2149613

ABSTRACT

The prolactin (PRL) response to 20 mg of domperidone, a peripheral dopamine (DA) blocking agent, was evaluated in a group of 16 drug-free, acute, young schizophreniform and schizophrenic males and in a group of age-matched normal males. Although basal plasma PRL levels were normal, the PRL responses following domperidone were blunted in both patient groups. The PRL response was more blunted in the schizophreniform patients than in the schizophrenic patients. Possible explanations for these results include pharmacokinetic factors or abnormalities of the pituitary D2 DA receptors.


Subject(s)
Domperidone , Military Personnel/psychology , Prolactin/blood , Psychotic Disorders/diagnosis , Schizophrenia/diagnosis , Schizophrenic Psychology , Acute Disease , Adult , Brain/drug effects , Humans , Male , Psychotic Disorders/blood , Psychotic Disorders/psychology , Receptors, Dopamine/drug effects , Receptors, Dopamine D1 , Receptors, Dopamine D2 , Schizophrenia/blood
3.
Neuropsychobiology ; 23(1): 15-7, 1990.
Article in English | MEDLINE | ID: mdl-2280826

ABSTRACT

Growth hormone (GH), and prolactin (PRL) responses to the administration of growth hormone-releasing hormone (GHRH) (1 microgram/kg) were evaluated in a group of 18 drug-free, acute, young male schizophrenics and in a group of age-matched normal controls. Cortisol responses were also evaluated. No difference in mean plasma GH, PRL and cortisol plasma basal values or in GH and PRL responses to GHRH between schizophrenics and controls was observed. Our failure to demonstrate a difference in GH response to GHRH between schizophrenics and controls would seem to indicate that GH secretory pituitary reserve is intact in young acute male schizophrenics. Cortisol values did discriminate between schizophrenics and controls (p less than 0.05). In our sample, both schizophrenics and normal controls showed a slight but significant (p less than 0.03) and transitory increase in plasma PRL response to GHRH.


Subject(s)
Growth Hormone-Releasing Hormone , Growth Hormone/blood , Prolactin/blood , Schizophrenia/blood , Schizophrenic Psychology , Acute Disease , Adult , Humans , Hydrocortisone/blood , Male , Psychiatric Status Rating Scales , Schizophrenia/diagnosis
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