1.
Toxicon
; 70: 82-5, 2013 Aug.
Article
in English
| MEDLINE
| ID: mdl-23624384
ABSTRACT
This study presents the effects of two synthetic disulfide bond variants of cal16b, a 13-mer Ca²âº channel blocker conotoxin, on pro- and anti-inflammatory cytokine gene transcription in the murine macrophage-like cell line J774A.1 stimulated with LPS. The globular form (cal16b_1) acted as an anti-inflammatory agent; in contrast, the ribbon disulfide variant (cal16b_2) had a pro-inflammatory effect. Our results suggest that the pro- and anti-inflammatory effects are mediated by the three-dimensional structure.