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1.
J Biol Regul Homeost Agents ; 34(1): 111-121, 2020.
Article in English | MEDLINE | ID: mdl-32148012

ABSTRACT

During the menopause women may experience increased oxidative stress and decreased antioxidant capacity and, together with the decline of neurosteroids, this represents a risk factor for Alzheimer's disease. The aim of the present study was to test a functional food (FPP-ORI, Osato Research Institute, Gifu, Japan) on redox and mitochondrial efficiency in post-menopausal women. The study population consisting of 69 untreated post-menopausal women were given supplements as follows: Group A was given a multivitamin (MV) 1c 2 times a day, and group B was given FPP 4.5 g 2 times a day. Group C consisted of 23 fertile premenopausal women as the control group. The tests carried out on entry, and at 3 and 6 months were erythrocyte redox parameters, plasma oxidated proteins, brain-derived neurotrophic factor (BDNF) and peripheral blood mononuclear cell (PBMC) mitochondria cytochrome c oxidase Vmax activity. Menopausal women showed an increased malondialdehyde (MDA) (p<0.05 vs control) which was normalized by both treatments (p<0.05), but MV failed to do so in the BMI ≥26 subgroup (p<0.05). All other redox enzymes and BDNF were significantly lower in menopausal women and they responded only to FPP (p<0.05). Carbonyl protein level was higher in "BMI ≥ 26" subgroup (p<0.05) and reduced only by FPP (p<0.05). The PBMC cyclooxygenase to citrate synthase activity was reduced (<40%) in the menopausal group (p<0.01) and only FPP caused a significant restoration (p<0.05). Although preliminary, these data confirm the redox and mitochondrial dysfunction occurring in post-menopause and responsive to FPP but very poorly to high dosage antioxidants. This may lead to potential preventive opportunities in menopause-associated neurodegenerative disease.


Subject(s)
Functional Food , Mitochondria/pathology , Neurodegenerative Diseases/epidemiology , Postmenopause , Antioxidants/physiology , Brain-Derived Neurotrophic Factor/metabolism , Electron Transport Complex IV/metabolism , Female , Humans , Japan , Leukocytes, Mononuclear , Malondialdehyde/metabolism , Oxidation-Reduction , Oxidative Stress , Pilot Projects , Risk Factors
2.
Ann N Y Acad Sci ; 1067: 414-9, 2006 May.
Article in English | MEDLINE | ID: mdl-16804020

ABSTRACT

Twenty-month-old Swiss mice were allocated into three groups: (A) control; (B) infected group; and (C) infected but treated with 5 mg of the phytocompound MMT. Mice were infected intranasally with 30 microL of 75 HA viral units. MMT markedly blunted the nasal signs of virus infection and the febrile response. Formazan-positive cells, lung and plasma lipoperoxides, and TNF-alpha in lung tissue increased during viral infection, but improvement was seen in the MMT-treated group (P < 0.05). MMT also normalized SOD, catalase activities, and ascorbic acid and determined a significant decrease of lung but not nasal viral titer, although nasal inflammatory infiltrate dropped significantly. MMT has potential clinical applications with and has an excellent safety profile even in old animals.


Subject(s)
Aging/metabolism , Antioxidants/administration & dosage , Dietary Supplements , Orthomyxoviridae Infections/diet therapy , Administration, Oral , Animals , Ascorbic Acid/analysis , Bronchoalveolar Lavage Fluid/chemistry , Catalase/analysis , Chemokine CCL5/analysis , Disease Models, Animal , Drug Administration Schedule , Lung/enzymology , Lung/metabolism , Lung/virology , Mice , Orthomyxoviridae Infections/virology , Random Allocation , Superoxide Dismutase/analysis , Treatment Outcome , Tumor Necrosis Factor-alpha/analysis , Viral Load
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