ABSTRACT
The literature on serum lysozyme was reviewed and the normal values for this enzyme were analyzed in 40 healthy children (control group) and 40 children with a clinical diagnosis of septicemia. The patients were 1 to 18 months old and were hospitalized in the H.P. of the C.M.N., I.M.S.S. In 12 of these, the blood cultures developed bacteria, while 26 were negative. It was found that the normal values varied in healthy children from 5 to 24 microgram/ml. In the group of infected patients, the values varied from 4.4 to 53.3 microgram/ml. The group of healthy patients (control) was compared with the infected patients and a significantly difference was found (p less than 0.05), although in some infected children the readings for lysozyme were normal. In all patients, lysozyme returned to normal when the infection cleared. The mortality rate in this study was 15 per cent. It is concluded that in patients with severe infection, the levels of lysozyme in the serum may the elevated, while in patients with clinical signs of septicemia with positive blood cultures, there is a rise in lysozyme.
Subject(s)
Infant, Newborn, Diseases/enzymology , Muramidase/blood , Sepsis/enzymology , Bacteria/isolation & purification , Female , Humans , Infant , Infant, Newborn , Male , Sepsis/microbiologyABSTRACT
Se revisa literatura sobre la lisozima serica y se analizan los valores normales de esta enzima en 40 ninos sanos (grupo control), y 40 ninos de 1 a 18 meses con diagnostico clinico de septicemia, internados en el Hospital de Pediatria del Centro Medico Nacional del IMSS. En 12 de estos, el hemocultivo desarrollo bacterias y en 28 fue negativo. Se encontro que los valores normales en ninos sanos variaron entre 5 y 21 ug/ml. En el grupo de pacientes infectados, variaron entre 4.4 y 57.3 ug/ml. Se comparo el grupo de pacientes sanos (control) con el de infectados encontrando diferencia significativa (p<0.05), aunque en algunos pacientes con infeccion grave las cifras de lisozima fueron normales.En todos los pacientes, la lisozima se normalizo posteriormente a la curacion. La letalidad en este estudio fue del 15 por ciento.Se concluye que en los pacientes con infeccion grave, los niveles de lisozima serica pueden encontrarse elevados y en pacientes con cuadro clinico de septicemia y hemocultivo positivo la lisozima se encuentra elevada
Subject(s)
Muramidase , SepsisABSTRACT
The usefulness of five different laboratory tests for differential diagnosis in bacterial and viral meningoencephalitides was assessed. The clinical manifestations and cytochemical alterations of cerebrospinal fluid (CSF) were used as criteria for diagnostic selection. The causal agent was identified by means of CSF cultures in 47.8 per cent of bacterial meningoencephalitis cases; Gram stain was postive in CSF smear in 34.8 per cent and protein electrophoresis in CSF did not show significant differences when compared to cases of bacterial or viral etiology and the control group. PH and CSF lactate determinations allowed diagnosis of all cases of bacterial meningoencephalitis and was not modified in those cases where this disease was of a viral origin. We suggest to add these determinations to the initial cytochemical study of CSF in all cases where meningoencephalitis is suspected.
Subject(s)
Lactates/analysis , Meningitis, Viral/cerebrospinal fluid , Meningoencephalitis/cerebrospinal fluid , Child , Cytodiagnosis , Diagnosis, Differential , Humans , Hydrogen-Ion Concentration , Meningitis, Viral/microbiology , Meningoencephalitis/microbiology , Proteins/analysisABSTRACT
The case of a newborn with pathological confirmation of congenital pulmonary lymphangiectasis and hyaline membrane is reported. The lymphagiectasis corresponded to type III, with histological characteristics that make it different from other types of lymphatic dilatation. This association is quite uncommon and should be considered in the differential diagnosis of acute respiratory failure in the newborn period.
Subject(s)
Hyaline Membrane Disease/pathology , Lymphangiectasis/congenital , Diagnosis, Differential , Female , Humans , Infant, Newborn , Lung/pathology , Lymphangiectasis/pathology , Male , PregnancyABSTRACT
The study included 17 cases of osteomyelitis in the newborn period, admitted through a period of 10 years. Males showed a rate of 1.8:1 over females. The possible port of entry was established in 11 cases. The most important clinical signs were: edema, erythema, hypomotility and fluctuation. In one third of the cases, systemic infection signs were eident and in 4 cases, confirmation resulted from blood cultures positive to gram-negative germs. The germ most frequently isolated in the secretion was S. aureus, followed by Klebsiella. The analysis included the pathogenesis that explains the high percentage of articular participation (65%) and the presence of multiple foci which, together with other characteristics, make osteomyelitis at this age, different from that seen during other stages of life in terms of diagnosis, management and prognosis.
Subject(s)
Infant, Newborn, Diseases/diagnostic imaging , Osteomyelitis/diagnostic imaging , Bacteria/isolation & purification , Female , Humans , Infant, Newborn , Infant, Newborn, Diseases/microbiology , Male , Osteomyelitis/microbiology , Pregnancy , RadiographyABSTRACT
The study included 50 cases with this disease which were divided into 2 groups: above and under 2,500 g. A relationship was established among weight and bleeding site, type of delivery, prothrombin activity and lethality. It was found that those under 2,500 g. bled earlier than those above 2,500 g. With higher percentage, the bleeding site was the digestive tract in both groups. Most of both groups bled between the 2nd and 6th day and a group of special interest was made up of 8 patients who bled between the 10th and 28th day of life and that we included as hemorrhagic disease of the newborn because bleeding appeared within the neonatal stage; these patients fell within the group showing the lowest prothombin activity. Bleeding within the central nervous system was frequent and showed the highest lethality.