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1.
Injury ; 53(10): 3124-3129, 2022 Oct.
Article in English | MEDLINE | ID: mdl-35803747

ABSTRACT

BACKGROUND: Cannulated screws augmented with the medial buttress plate could confer greater biomechanical stability and higher union rates than the screw fixation alone for treating young patients with Pauwels type III femoral neck fractures (FNFs). No study has evaluated the effects of distal bicortical screw fixation and biomechanical properties of buttress plate augmentation under simultaneous vertical and rotational forces, physiologically acting on the hip joint. This study aimed to compare the biomechanical properties of four methods of three cannulated screw fixation under the combined axial and torsional loading in a synthetic femur model of type III FNF. METHODS: Twenty-four third-generation composite femora were divided into four groups (6 femora in each group) based on the screw fixation configuration: inverted triangle configuration (Group A),  Pauwels' configuration (Group B), inverted triangle configuration combined with medial buttress plate using distal unicortical (Group C), and distal bicortical screw placement (Group D). A Pauwels type III FNF was simulated on the sawbones. Each model was subjected to the combined axial and torsional cyclic loading and subsequently tested to failure. RESULT: Significant differences were determined in axial stiffness (AS) among the four groups (p = 0.024), whereas there was no significant difference in torsional stiffness (p = 0.147). The mean AS was higher in group D (639.5 ± 86.2 N/mm) than in group A (430.6 ± 94.8 N/mm), group B (426.2 ± 41.9 N/mm), and group C (451.2 ± 156.7 N/mm). Failure forces (FFs) were significantly different among four groups (p = 0.007), while there was no considerable difference in failure moment values (p = 0.555). The mean FF was significantly higher in group D (1307.1 ± 96.4 N) than in group A  (1076.9 ± 371.2 N) and group B (1075.5 ± 348.3 N) (p = 0.014 and p = 0.018, respectively). There was no significant difference in the mean FF between groups D and C. CONCLUSION: Regardless of the medial plate use, multiple cannulated systems could provide similar biomechanical results regarding torsional stiffness and failure moments. Bicortical placement of the most distal screw in medial buttress plate application could improve axial stability but not significantly affect the rotational stability of the inverted triangle screw fixation system in managing type III FNFs.


Subject(s)
Femoral Neck Fractures , Biomechanical Phenomena , Bone Plates , Bone Screws , Femoral Neck Fractures/surgery , Femur , Fracture Fixation, Internal/methods , Humans
2.
Bioorg Chem ; 120: 105566, 2022 03.
Article in English | MEDLINE | ID: mdl-34974209

ABSTRACT

A series of chiral and achiral cyclic seleno- and thiourea compounds bearing benzyl groups on N-atoms were prepared from enetetramines and appropriate Group VI elements in good yields. All the synthesized compounds were characterized by elemental analysis, FT-IR, 1H NMR and 13C NMR spectroscopy, and the molecular and crystal structures of (R,R)-4b and (R,R)-5b were confirmed by the single-crystal X-ray diffraction method. These assayed for their activities against metabolic enzymes acetylcholinesterase, butyrylcholinesterase, and α-glycosidase. These selenourea and thiourea derivatives of chiral and achiral enetetramines effectively inhibit AChE and BChE with IC50 values in the range of 3.32-11.36 and 1.47-9.73 µM, respectively. Also, these compounds inhibited α-glycosidase enzyme with IC50 values varying between 1.37 and 8.53 µM. The results indicated that all the synthesized compounds exhibited excellent inhibitory activities against mentioned enzymes as compared with standard inhibitors. Representatively, the most potent compound against α-glycosidase enzyme, (S,S)-5b, was 12-times more potent than standard inhibitor acarbose; 7b and 8a as most potent compounds against cholinesterase enzymes, were around 5 and 13-times more potent than standard inhibitor tacrine against achethylcholinesterase (AChE) and butyrylcholinesterase (BChE), respectively.


Subject(s)
Acetylcholinesterase , Butyrylcholinesterase , Acetylcholinesterase/metabolism , Butyrylcholinesterase/metabolism , Cholinesterase Inhibitors/chemistry , Glycoside Hydrolases/metabolism , Molecular Docking Simulation , Molecular Structure , Organoselenium Compounds , Spectroscopy, Fourier Transform Infrared , Structure-Activity Relationship , Thiourea/pharmacology , Urea/analogs & derivatives
3.
Acta Orthop Traumatol Turc ; 54(5): 473-477, 2020 Sep.
Article in English | MEDLINE | ID: mdl-33155554

ABSTRACT

OBJECTIVE: The aims of this study were, first, to assess the loss of reduction after fixation of Rockwood type V acromioclavicular joint dislocation (ACJD) with the TightRope device (Arthrex, Naples, FL, USA) and, second, to present the functional and radiological outcomes of this treatment. METHODS: We retrospectively reviewed the medical records of 15 patients (12 males; mean age=39.2 years; age range=23-61) with Rockwood type V ACJD who were treated by the TightRope fixation device. The mean follow-up period was 19.3 (range=12-30) months. Functional status was assessed using the Constant-Murley score (CMS) at the final follow-up examination. To determine the reduction loss of ACJ, we measured and compared the coracoclavicular (CC) distance using radiographs with Zanca view in the early postoperative period and at the final follow-up examination. The fixation procedures were performed with an open technique using the TightRope fixation device. RESULTS: The mean CMS at the final follow-up was 93.2 (range=82-100) points. All the patients experienced full recovery of the shoulder's range of motion, were able to return to the activities of daily living, and were satisfied with the treatment. ACJ reduction was successfully achieved in all the patients using the TightRope technique. Postoperative radiographs revealed no reduction loss in the ACJ, and the CC distance was well maintained. The mean CC distance was 19.95 (range=13.1-28.3) mm before surgery. The mean CC distance was 7.47 (range=4.2-11.5) mm in the early postoperative radiographic measurements. This difference was statistically significant (p=0.001). The mean CC distance at the final follow-up examination was 7.70 (range=4.5-11.7) mm. At the final follow-up visit, the shoulders of all the patients were still completely reduced, with a mean difference in the CC of 0.23 (range=0-1.3) mm compared with that in the early postoperative period. The difference in the CC between the early postoperative and final follow-up intervals was not statistically significant (p=0.055). No patient experienced recurrence or required an operation for hardware removal. CONCLUSION: It seems that the TightRope device can provide anatomical restoration in patients with acute type V ACJD without subluxation at the final follow-up examination. LEVEL OF EVIDENCE: Level IV, Therapeutic study.


Subject(s)
Internal Fixators/adverse effects , Joint Dislocations , Orthopedic Procedures , Radiography/methods , Recovery of Function , Shoulder Dislocation , Acromioclavicular Joint/diagnostic imaging , Acromioclavicular Joint/injuries , Acromioclavicular Joint/surgery , Activities of Daily Living , Adult , Female , Humans , Joint Dislocations/diagnosis , Joint Dislocations/surgery , Male , Orthopedic Procedures/adverse effects , Orthopedic Procedures/instrumentation , Orthopedic Procedures/methods , Outcome and Process Assessment, Health Care , Postoperative Period , Range of Motion, Articular , Recurrence , Retrospective Studies , Shoulder Dislocation/diagnosis , Shoulder Dislocation/surgery , Treatment Outcome
4.
Jt Dis Relat Surg ; 31(3): 515-522, 2020.
Article in English | MEDLINE | ID: mdl-32962584

ABSTRACT

OBJECTIVES: This study aims to investigate the effects of deltopectoral and anterolateral acromial approaches commonly used in open reduction-internal fixation of proximal humeral fractures on the clinical outcomes, and axillary nerve damage through electrophysiological assessment. PATIENTS AND METHODS: Forty-eight patients (22 males, 26 females; mean age 47.9±13.2 years; range, 22 to 73 years) diagnosed with Arbeitsgemeinschaft für Osteosynthesefragen (AO)/Orthopaedic Trauma Association (OTA) type 11 proximal humeral fractures who underwent osteosynthesis with anatomical locking plates in our hospital between January 2015 and June 2016 were prospectively examined. The patients were divided into two groups according to either the deltopectoral or anterolateral deltoid-split surgical approach used. Clinical outcomes were evaluated using the Disabilities of the Arm, Shoulder, and Hand (DASH) scores and Constant-Murley scores (CMS) obtained at three- and 12-month follow-up visits. Needle electromyography (EMG) was performed for the electrophysiological assessment of the deltoid muscle. RESULTS: There were no significant differences between the groups in terms of demographic data, follow-up times, and complications. DASH scores and CMS obtained postoperatively at three months (p=0.327 and p=0.531, respectively) and 12 months (p=0.324 and p=0.648, respectively) revealed no significant differences. In addition, the two groups did not significantly differ with respect to the presence of EMG abnormalities (p=0.792). Avascular necrosis of the humeral head was detected in only two patients from the deltopectoral group. CONCLUSION: Deltopectoral and anterolateral approaches do not differ regarding the presence of postoperative EMG abnormalities and functional outcomes. Surgeons can thus adopt either approach. However, dissection without damaging the soft tissue should be performed in both approaches.


Subject(s)
Deltoid Muscle , Fracture Fixation, Internal , Open Fracture Reduction , Peripheral Nerve Injuries , Postoperative Complications , Shoulder Fractures/surgery , Deltoid Muscle/innervation , Deltoid Muscle/physiopathology , Disability Evaluation , Electromyography/methods , Female , Fracture Fixation, Internal/adverse effects , Fracture Fixation, Internal/instrumentation , Fracture Fixation, Internal/methods , Humans , Male , Middle Aged , Open Fracture Reduction/adverse effects , Open Fracture Reduction/methods , Peripheral Nerve Injuries/diagnosis , Peripheral Nerve Injuries/etiology , Peripheral Nerve Injuries/physiopathology , Postoperative Complications/diagnosis , Postoperative Complications/physiopathology , Shoulder/physiopathology , Shoulder/surgery , Treatment Outcome
5.
Knee ; 27(3): 891-898, 2020 Jun.
Article in English | MEDLINE | ID: mdl-32201042

ABSTRACT

BACKGROUND: In clinical practice, soft tissue interposition may occur during femoral graft fixation. Soft tissue interposition between the lateral femoral cortex and the cortical button may affect graft tension and related longitudinal graft motion in the tunnel. We aimed to investigate the effect of soft tissue interposition on button migration and clinical outcomes in anatomical single-bundle anterior cruciate ligament reconstruction. METHODS: Eighty-four patients aged 18-40 years, who underwent anatomical single-bundle anterior cruciate ligament reconstruction with quadruple hamstring autograft were included. Patients were divided into two groups as Group 1 (n = 32) with soft tissue interposition between the cortical button and cortex, and Group 2 (n = 52) without soft tissue interposition. At the one-year follow-up visit, the anteroposterior knee stability of the patients was evaluated using the Lachman test and KT-2000 arthrometer, and rotational stability was assessed with the pivot shift test. The Lysholm knee score was used to evaluate the functional outcome of the patients. Relationship between tissue interposition and clinical outcome, and button migration was examined. RESULTS: Button migration was observed in 12 patients in Group 1 (37.5%) and two patients (3.84%) in Group 2 (p < 0.001). However, no significant difference was observed between patients with and without tissue interposition or those with and without button migration regarding knee stability parameters and clinical outcome (p < 0.05). CONCLUSIONS: Postoperative tissue interposition is found to be associated with cortical button migration during the follow-up. However, it does not affect the clinical outcome.


Subject(s)
Anterior Cruciate Ligament Reconstruction/methods , Foreign-Body Migration/diagnostic imaging , Orthopedic Fixation Devices , Adolescent , Adult , Autografts , Female , Follow-Up Studies , Humans , Knee Joint/diagnostic imaging , Male , Radiography , Tendons/transplantation , Young Adult
6.
J Orthop Surg (Hong Kong) ; 27(2): 2309499019836300, 2019.
Article in English | MEDLINE | ID: mdl-30885046

ABSTRACT

PURPOSE: To evaluate the short-term clinical and radiological outcomes with degenerative changes in patients over 40 years old following isolated vertical medial meniscal tear repair. METHODS: Between 2007 and 2015, 438 patients underwent arthroscopic meniscal repair. Thirty-three patients aged over 40 years with isolated vertical medial meniscal repair (23 males and 10 females, mean age 46.1 ± 7.0; range 40-67) were included in the study. Preoperative and postoperative physical examination findings, Lysholm knee score, the International Knee Documentation Committee score, magnetic resonance imaging findings, and Kellgren-Lawrence osteoarthritis stage were evaluated. RESULTS: The mean follow-up period was 31.1 months ± 20.1 (range 12-100 months). There was statistically significant improvement in functional scores ( p < 0.05) and physical examination findings. In 22 patients (66.7%), improvement in the clinical and radiological results was detected ( p < 0.05). However, no correlation was found between clinical and radiological outcomes. There was also no significant change in osteoarthritis stages at the last follow-up visit. No significant difference was found between smokers and nonsmokers regarding clinical outcomes. CONCLUSION: Successful clinical and radiological outcomes can be obtained following isolated vertical medial meniscal tear repair in patients older than 40 years. Age is not the sole criterion for the success of meniscal repair; rather, the functional capacity of the patient, the location of the tear, the grade of knee joint arthritis, and the quality of the meniscal tissue should be taken into consideration.


Subject(s)
Arthroscopy/methods , Knee Joint/surgery , Magnetic Resonance Imaging/methods , Menisci, Tibial/surgery , Tibial Meniscus Injuries/surgery , Adult , Aged , Female , Humans , Knee Joint/diagnostic imaging , Lysholm Knee Score , Male , Middle Aged , Postoperative Period , Radiography/methods , Rupture , Tibial Meniscus Injuries/diagnosis
7.
Acta Orthop Traumatol Turc ; 53(1): 30-34, 2019 Jan.
Article in English | MEDLINE | ID: mdl-29773449

ABSTRACT

OBJECTIVE: The aim of this study was to discuss the diagnosis and surgical management and their results according to stage of primary bone tumors at ulna and to share our experience on this exceptional location for bone tumors. METHODS: We have retrospectively reviewed our clinics database and identified 23 cases (14 males and 9 females, mean age was 28.9 (range 4-77)) with primary bone tumors and tumor like lesion involvement of ulna. The patients were evaluated according to complaints, type and grade of tumor, treatment, recurrence and functional status. RESULTS: The most common first referral complaint was constrictive pain in 52.1% of the cases, benign tumors and tumor like lesions of the bone constituted 73.9% whereas malignant bone tumors were 26.1%, 39.1% of the lesions were located in distal end of ulna and the mean follow up was 33.8 months (range 8-172 months). Local recurrence has unexpectedly occurred in 3 benign lesions (13.1%). CONCLUSION: Benign bone lesions tend to involve distal and proximal ends, malign bone lesions involve diaphysis mostly. Both benign and malignant diaphyseal lesions of the ulna have better postoperative results regarding the lesions at both ends of ulna. One should also take care of recurrences even after a decade from the primary surgery. LEVEL OF EVIDENCE: Level IV, Therapeutic study.


Subject(s)
Bone Neoplasms , Orthopedic Procedures , Ulna , Adult , Bone Neoplasms/pathology , Bone Neoplasms/surgery , Diaphyses/pathology , Female , Humans , Male , Neoplasm Recurrence, Local/diagnosis , Neoplasm Staging , Orthopedic Procedures/adverse effects , Orthopedic Procedures/methods , Postoperative Complications/epidemiology , Retrospective Studies , Turkey/epidemiology , Ulna/diagnostic imaging , Ulna/pathology , Ulna/surgery
8.
Knee Surg Sports Traumatol Arthrosc ; 27(3): 898-904, 2019 Mar.
Article in English | MEDLINE | ID: mdl-30269172

ABSTRACT

PURPOSE: The purpose of this study was to evaluate the role of surgeons' experience with meniscal repairs and meniscectomy decisions, and to determine the factors affecting the disagreement between meniscal repairs and meniscectomy decisions. METHODS: In total, 223 patients with meniscal tears, 106 meniscal repairs, and 117 meniscectomies were included. Six orthopedic surgeons (3: > 5 years; 3: < 5 years' arthroscopy experience) were blinded, and they independently reviewed all preoperative MR images for over a month. Their reviews were compared with arthroscopic interventions performed by a surgeon with > 10 years' arthroscopy experience. Reparability-associated factors were also evaluated using multivariate logistic regression. RESULTS: The first and second evaluation results did not differ significantly between groups (n.s.). There was good agreement between MRI predictions and arthroscopic interventions for both groups (< 5 years' experience: k = 0.248, agreement 62.3%; > 5 years' experience: k = 0.351, agreement 67.3%). Sex, side, and distance of tear from the meniscocapsular junction were not significantly different between agreements and disagreements. Disagreement regarding meniscectomy was significantly higher than those regarding meniscus repair (p = 0.002). Concomitant anterior cruciate ligament (ACL) injury, osteochondral lesions, and medial meniscal tear increased the likelihood of meniscal repair (p = 0.0063, p = 0.0010, and p = 0.0369, respectively). An increased risk of disagreement between MRI and surgical procedure was found in the presence of bucket-handle, horizontal or complex tear, chronic tear, high sports activity and expectation level. CONCLUSION: Surgeon's experience level may influence the prediction of meniscus reparability. Concomitant ACL injury, osteochondral lesions, and presence of medial meniscal tear increase the likelihood of meniscal repair. Tear type, tear chronicity, patient's activity and expectation level may influence the surgeon's operative decision in addition to MRI. LEVEL OF EVIDENCE: III.


Subject(s)
Clinical Decision-Making , Magnetic Resonance Imaging , Tibial Meniscus Injuries/diagnostic imaging , Adolescent , Adult , Anterior Cruciate Ligament Injuries , Arthroscopy , Cartilage, Articular/injuries , Clinical Competence , Female , Humans , Male , Meniscectomy , Middle Aged , Tibial Meniscus Injuries/surgery , Young Adult
9.
Arch Orthop Trauma Surg ; 138(3): 427-434, 2018 Mar.
Article in English | MEDLINE | ID: mdl-29396634

ABSTRACT

INTRODUCTION: We report the short-term outcomes of total hip arthroplasty(THA) in patients previously treated with Schanz osteotomy (SO). MATERIALS AND METHODS: Eighteen patients [2 male, 16 female; mean age, 55.4 (range, 50-66) years] who had undergone THA after SO were retrospectively evaluated. Clinical evaluation was performed based on the Harris hip score. Radiological evaluation was performed using full-length radiographs of the lower extremities, pelvis, and hip. RESULTS: The mean follow-up period was 30.8 (range, 18-56) months. Mean femoral shortening was 3.7 (range, 2-5) cm. Perioperative complications occurred in 4 (22.2%) patients. Nonunion was not found at the osteotomy sites. No dislocation was observed. The Trendelenburg sign was positive for five (27.7%) patients, postoperatively. The mean Harris hip score improved from 42.7 to 78.7 (p < 0.05). CONCLUSION: THA for hips previously treated with SO is technically demanding. If careful preoperative planning is performed, successful treatment can be achieved.


Subject(s)
Arthroplasty, Replacement, Hip/methods , Hip Dislocation/surgery , Osteotomy/methods , Aged , Female , Femur/diagnostic imaging , Femur/surgery , Humans , Male , Middle Aged , Osteotomy/adverse effects , Retrospective Studies
10.
J Knee Surg ; 31(6): 514-519, 2018 Jul.
Article in English | MEDLINE | ID: mdl-28719940

ABSTRACT

The literature contains very limited articles wherein the treatment results of bucket-handle meniscal tears according to various types are evaluated and wherein results for repair of chronic tears are discussed. The objective of this study is a clinical and radiologic evaluation of arthroscopic repair for patients suffering flipped, neglected chronic bucket-handle meniscal tear in the intercondylar notch. A total of 26 patients were evaluated retrospectively. The mean age at the time of surgery was 27 years (range, 16-44). Mean period from meniscal injury to surgery was 28 months (range, 4-96). The mean follow-up period was 31 months (range, 11-67). During the follow-up, the patients were evaluated clinically, functional scores from the International Knee Documentation Committee (IKDC), Lysholm, and Tegner as well as magnetic resonance imaging (MRI). The mean preoperative Lysholm score of 24 increased to 85 postoperatively. Mean IKDC score was 56.3 preoperatively and 84.5 postoperatively. The mean Tegner score of 3.4 increased to 5.6 postoperatively. Mean Lysholm, IKDC, and Tegner scores in the first group were 84, 74, and 5.1, respectively, and in the anterior cruciate ligament (ACL) reconstruction group; 86, 85.9, and 5.8. While 20 (77%) out of 26 patients had none of the clinical findings, 6 patients (23%) presented with these findings. Postoperative MRI assessment revealed meniscal healing in 21 patients (27% complete, 54% partial healing) and no healing in 5 patients (19%). A clinical healing rate of 77% and a radiological healing rate of 81% along with statistically significant increases in Lysholm, IKDC, and Tegner scores prove that the repair option is effective for neglected, chronic bucket-handle meniscal tears flipping to the intercondylar notch. This study showed that good results could be achieved with the repair of neglected, chronic period bucket-handle meniscal tears flipping to the intercondylar notch, whether with an accompanying ACL tear or not.


Subject(s)
Knee Injuries/surgery , Tibial Meniscus Injuries/surgery , Adolescent , Adult , Anterior Cruciate Ligament Injuries/surgery , Arthroscopy , Chronic Disease , Delayed Diagnosis , Female , Humans , Knee Injuries/diagnostic imaging , Magnetic Resonance Imaging , Male , Retrospective Studies , Tibial Meniscus Injuries/diagnostic imaging , Young Adult
11.
Acta Orthop Traumatol Turc ; 51(6): 455-458, 2017 Dec.
Article in English | MEDLINE | ID: mdl-29032901

ABSTRACT

OBJECTIVE: The aim of this study was to compare the long-term clinical and radiological results of Acromioclavicular (AC) fixation with K-wires (the modified Phemister procedure) and Coracoclavicular (CC) fixation with the Bosworth screw in the surgical treatment of Type 3 AC joint dislocations. METHODS: Thirty-two patients with complete set of medical records and who received surgical treatment between September 2005 and January 2009 due to acute Rockwood Type 3 AC joint dislocation and properly attended their follow-ups were retrospectively evaluated. Sixteen patients (13 males, 3 females; mean age: 38, range: 24-52 years) were treated with CC fixation with Bosworth screw (Group 1), and the other 16 (12 males, 4 females; mean age: 53.3, range: 38-64 years) with AC fixation using K-wires (Group 2). RESULTS: The mean follow-up time was 96 months for Group 1 and 93 months for Group 2 patients (p > 0.05). The mean Constant-Murley score at the final follow-up was 84.7 in Group 1 and 87.3 in Group 2 (p = 0.069). Radiological evaluation of the patients revealed AC arthrosis in 2 and 3 patients in Group 1 and 2, respectively. In Group 2, one patient had a recurrent dislocation, three patients had AC arthrosis and two patients had ossification in the CC ligament (Fig. 2). There was no superficial or deep wound infection in Group 1, while two patients from Group 2 had a superficial wound infection. CONCLUSIONS: Our results suggest that both techniques are reliable and provide adequate reduction and similar outcomes in terms of functionality and pain levels, following the reduction of Type 3 AC joint dislocations. With lower rates of wound site infection in the early and AC arthrosis in the late postoperative period, CC fixation method with the Bosworth screw may be a better surgical option than AC fixation method with K-wires. LEVEL OF EVIDENCE: Level III, Therapeutic study.


Subject(s)
Acromioclavicular Joint , External Fixators , Internal Fixators , Joint Dislocations , Long Term Adverse Effects , Orthopedic Procedures , Pain, Postoperative , Acromioclavicular Joint/physiopathology , Acromioclavicular Joint/surgery , Adult , Female , Humans , Joint Dislocations/diagnosis , Joint Dislocations/physiopathology , Joint Dislocations/surgery , Ligaments, Articular/surgery , Long Term Adverse Effects/diagnosis , Long Term Adverse Effects/etiology , Long Term Adverse Effects/physiopathology , Male , Middle Aged , Orthopedic Procedures/adverse effects , Orthopedic Procedures/instrumentation , Orthopedic Procedures/methods , Pain, Postoperative/diagnosis , Pain, Postoperative/etiology , Radiography/methods , Recovery of Function , Retrospective Studies , Treatment Outcome
12.
Biomater Sci ; 5(10): 2144-2158, 2017 Sep 26.
Article in English | MEDLINE | ID: mdl-28880313

ABSTRACT

A large variety of approaches have been used to treat large and irregular shaped bone defects with less than optimal success due to material or design issues. In recent years patient specific constructs prepared by additive manufacturing provided a solution to the need for shaping implants to fit irregular defects in the surgery theater. In this study, cylindrical disks of poly(ε-caprolactone) (PCL) were printed by fused deposition modeling and modified with nanohydroxyapatite (HAp) and poly(propylene fumarate) (PPF) to create a mechanically strong implant with well-defined pore size and porosity, controllable surface hydrophilicity (with PPF) and osteoconductivity (with HAp). Cytotoxicity, irritation and inflammation tests demonstrated that the scaffolds were biocompatible. PCL/HAp and PCL/HAp/PPF scaffolds were implanted in the femurs of rabbits with and without seeding with rabbit Bone Marrow Stem Cells (BMSC) and examined after 4 and 8 weeks with micro-CT, mechanically and histologically. BMSC seeded PCL/HAp/PPF scaffolds showed improved tissue regeneration as determined by bone mineral density and micro-CT. Compressive and tension stiffness values (394 and 463 N mm-1) were significantly higher than those of the healthy rabbit femur (316 and 392 N mm-1, respectively) after 8 weeks of implantation. These 3D implants have great potential for patient-specific bone defect treatments.


Subject(s)
Biocompatible Materials/pharmacology , Durapatite/chemistry , Femur/drug effects , Femur/physiology , Fumarates/chemistry , Polyesters/chemistry , Polypropylenes/chemistry , Printing, Three-Dimensional , Animals , Biocompatible Materials/chemistry , Cell Differentiation/drug effects , Cell Line , Cell Proliferation/drug effects , Femur/cytology , Materials Testing , Mechanical Phenomena , Mesenchymal Stem Cells/cytology , Mesenchymal Stem Cells/drug effects , Mice , Models, Molecular , Molecular Conformation , Osteogenesis/drug effects , Rabbits , Tissue Engineering , Wound Healing/drug effects
13.
Acta Orthop Traumatol Turc ; 51(4): 273-277, 2017 Jul.
Article in English | MEDLINE | ID: mdl-28698016

ABSTRACT

OBJECTIVES: The aim of this prospective study is to evaluate the impact of the simulation training program in learning duration of arthroscopic motor skills. Furthermore, we investigated the difference between junior and experienced residents in the improvement of arthroscopic motor skills duration. METHODS: We established 2 study groups according to participants' year of experience in orthopedic residency with junior group residents with three years or less than three years experience as group 1 and experienced group with over 3 years of experience as group 2. We calculated duration change of motor skill test results for each participant before and after the course. The tools used were; auto scoring mirror tracer(ASMT), 0'Conner the tweezer dexterity test(OCTDT), etch-a-sketch with overlay(ESOT), purdue the pegboard test(PPT), two-arm coordination test(TACT) and grooved pegboard test(GPT) which were all produced by Lafayette firm. These instruments were used to practice and measure the basic motor skills. RESULTS: All post-course test durations for participants decreased significantly when compared to pre-course. We calculated percentage change of motor skill test results for each participant before and after the course. All motor skill test percentage changes were similar between two groups. In comparison of participants according to their experiences, results revealed that there was no difference in test results of experienced and junior surgeons. Both groups had provided equal improvement in terms of motor skills. CONLUSION: As our results revealed, residents will be able to act with a strong motivation to learn applications through basic arthroscopic information gained in early period of orthopedic training and will make more successful applications of real patients.


Subject(s)
Arthroscopy , Clinical Competence , Knee Joint/surgery , Motor Skills , Orthopedics , Adult , Arthroscopy/education , Arthroscopy/methods , Arthroscopy/psychology , Female , Humans , Internship and Residency , Male , Orthopedics/education , Orthopedics/standards , Prospective Studies , Simulation Training/methods , Time Factors , Turkey
14.
SICOT J ; 2: 42, 2016.
Article in English | MEDLINE | ID: mdl-27892399

ABSTRACT

Arthroscopic repair of bucket-handle meniscal tears is difficult due to their complex pathology. Many meniscal repair techniques such as all-inside, inside-out, and outside-in have been described for the treatment of these tears. Loss of reduction is a likely complication with the use of new-generation, all-inside suture instruments, as the tip of the needle is extracted following advancement of the first implant behind the capsule. The complication may be encountered quite often and renders the use of the meniscus repair instrument unusable and causes an irreparable iatrogenic injury in the meniscus. The application of a simpler and more efficient technique is necessary until surgical experience is gained. The aim of this study was to define a new, simpler, and more efficient combination of suturing method in the treatment of bucket-handle meniscal repairs and minimize the rate of complications which may be caused by this technique.

15.
J Pak Med Assoc ; 66(9): 1142-1148, 2016 09.
Article in English | MEDLINE | ID: mdl-27654736

ABSTRACT

OBJECTIVE: To evaluate the results of the minimally invasive internal fixation method using reverse Less Invasive Stabilisation System locking plate in unstable proximal femur extracapsular fractures. METHODS: The retrospective study was conducted at Department of Orthopaedics in Taksim Training and Research Hospital (Istanbul, Turkey) and comprised data of patients in whom osteosynthesis was applied with reverse Less Invasive Stabilisation System locking plate for an unstable extracapsular femur fracture between September 2006 and June 2011. Evaluation was made of the fracture reduction quality and degrees of varus-valgus and anteversion-retroversion on the postoperative radiographs which were compared to the healthy hip. At the final follow-up examination, evaluation was made using the Harris Hip Score and Visual Analogue Scale score. The follow-up period ranged from 12 to 35 months. RESULTS: Of the 42 patients, 16 (38%) were females and 26 (62%) were males, with an overall mean age of 64.2±22.25 years (range: 23-97 years). The trauma was low-energy in 24 (57%) patients and high-energy in 18 (43%). Union was achieved in 38 (90%) patients with secondary bone healing in mean 14 weeks (range: 12-20 weeks). Complications were seen in 4 (9%) patients and additional surgical interventions were made. Radiographically, reduction was anatomic in 33 (79%) patients, acceptable in 8 (19%) and poor in 1 (2%). At the 12-month follow-up, the mean Harris Hip Score was 88,6 (range: 59-100) and mean Visual Analogue Scale score was 2.19 (range: 0-9). CONCLUSIONS: In the surgical treatment of unstable extracapsular proximal femur fractures, reverse Less Invasive Stabilisation System plate could be easily applied with a minimally invasive fixation method as an alternative to other treatment methods with successful results.


Subject(s)
Bone Plates , Femoral Fractures/surgery , Fracture Fixation, Internal , Adult , Aged , Aged, 80 and over , Female , Fracture Healing , Humans , Male , Middle Aged , Minimally Invasive Surgical Procedures , Radiography , Retrospective Studies , Treatment Outcome , Turkey , Young Adult
16.
Ulus Travma Acil Cerrahi Derg ; 22(3): 283-9, 2016 May.
Article in English | MEDLINE | ID: mdl-27598595

ABSTRACT

BACKGROUND: The aim of the present study was to evaluate the effect of locking compression plate (LCP) and autografting application in patients with nonunion of forearm fractures on radiologic and clinical outcome. METHODS: A total of 26 patients (16 males, 10 females; mean age: 45.7 years) with nonunion after surgical treatment of forearm fractures were included. Nonunion was located in the ulna in 14 patients, in the radius in 5 patients, and in both in 7 patients (21 ulna, 12 radius).Infection markers were checked prior to surgery. Samples for microbiologic cultures were peroperatively obtained in 7 patients with a history of open fractures. Autografting from the iliac crest and 3.5-mm LCP were applied. Type of nonunion, time to unification, range of motion in the wrist and elbow joints, and complications were analyzed. Functional evaluation was performedusing the scoring system described by Anderson et al. RESULTS: Mean follow-up period was 49.3 months (range 24-73 months). Unification was achieved in a mean 5.7 months (range 3-14 months). Additional surgical process was not required. No bacterial proliferation was observed in cultures. Superficial infection was observed in 3 patients and deep infection in 1. Results were scored as excellent in 10 (38.4%) patients, satisfactory in 13 (50%), and unsatisfactory in 3 (11.6%). CONCLUSION: Treatment of aseptic forearm nonunion in adults with autografting from the iliac crest and 3.5-mmLCP fixation increases unification rate and aids in function recovery.


Subject(s)
Bone Plates , Outcome Assessment, Health Care , Radius Fractures/surgery , Ulna Fractures/surgery , Adolescent , Adult , Aged , Autografts , Female , Fracture Fixation, Internal , Humans , Male , Middle Aged , Radius Fractures/diagnostic imaging , Radius Fractures/epidemiology , Radius Fractures/pathology , Range of Motion, Articular , Recovery of Function , Surgical Wound Infection/epidemiology , Turkey/epidemiology , Ulna Fractures/diagnostic imaging , Ulna Fractures/epidemiology , Ulna Fractures/pathology , Young Adult
17.
J Foot Ankle Surg ; 55(5): 1003-6, 2016.
Article in English | MEDLINE | ID: mdl-27432027

ABSTRACT

The aim of the present study was to clinically evaluate whether the presence of subchondral cysts had an effect on the treatment results of autologous osteochondral graft transfer in osteochondral lesions of the talus. Patients were enrolled in the present study according to the inclusion criteria. In the evaluation, we divided the patients into 2 groups according to presence (n = 13 patients) or absence (n = 15 patients) of a subchondral cyst. The mean age, body mass index, follow-up period, and lesion size in each group were measured and compared, and no statistically significant differences were found between the 2 groups (p > .05). The clinical assessment was performed using the American Orthopaedic Foot and Ankle Society Hindfoot scoring system, visual analog scale, and International Knee Society scoring system. No statistically significant difference was found between the pre- and postoperative scores of the 2 patient groups (p > .05). The successful results in both groups after a 2-year follow-up period have demonstrated that treatment of osteochondral lesions of the talus with osteochondral graft transfer is a safe method that can be performed independently of the presence of a subchondral cyst.


Subject(s)
Bone Cysts/surgery , Bone Transplantation/methods , Osteochondritis Dissecans/surgery , Talus/surgery , Adolescent , Adult , Bone Cysts/diagnostic imaging , Bone Transplantation/rehabilitation , Cohort Studies , Female , Follow-Up Studies , Graft Survival , Humans , Magnetic Resonance Imaging/methods , Male , Middle Aged , Osteochondritis Dissecans/diagnostic imaging , Pain/physiopathology , Pain/surgery , Pain Measurement , Postoperative Care/methods , Retrospective Studies , Risk Assessment , Splints , Statistics, Nonparametric , Talus/diagnostic imaging , Transplantation, Autologous , Treatment Outcome , Young Adult
18.
J Ultrasound Med ; 35(6): 1269-75, 2016 Jun.
Article in English | MEDLINE | ID: mdl-27151910

ABSTRACT

OBJECTIVES: The purpose of this study was to investigate the interobserver, intraobserver, and intermethod reliability of computer-assisted digital and manual measurements of hip sonograms. METHODS: Seventy-four hip sonograms were evaluated in this retrospective study. Five evaluators measured digital images and manual paper printouts according to the Graf method (Arch Orthop Trauma Surg 1984; 102:248-255). Interobserver and intraobserver reliability rates were calculated. Reliability criteria were graded on a numeric scale. RESULTS: The interobserver reliability of both computer-based and manual methods for alpha angle measurements was good to excellent, but the interobserver reliability was fair to poor for beta angle measurements. Intraobserver reliability was varied. Alpha angle measurements by both manual and computer-based methods had high concordance with each other, whereas beta angle measurements had low concordance. The intermethod variability did not differ between observers. CONCLUSIONS: The alpha angle measurements had high concordance with each other for both manual and computer-based methods, whereas the beta angle measurements had low concordance. This information should be taken into account in clinical practice. Overall, the two measurement methods were reliable and consistent with each other.


Subject(s)
Hip Dislocation, Congenital/diagnostic imaging , Hip Joint/diagnostic imaging , Image Processing, Computer-Assisted/methods , Ultrasonography/methods , Female , Humans , Infant , Infant, Newborn , Male , Observer Variation , Reproducibility of Results , Retrospective Studies
19.
Int Orthop ; 40(10): 2121-2126, 2016 Oct.
Article in English | MEDLINE | ID: mdl-27079838

ABSTRACT

INTRODUCTION: The aim of this study was to compare the radiological and functional results of two different methods of fixation for the correction of femoral valgus deformities. METHODS: Patients who had undergone osteotomy and correction of a valgus deformity from 2007 to 2013 were prospectively followed. Thirty three patients (20 females, 13 males) with 39 lower limbs were included in the study. Seventeen lower limbs were treated with retrograde intramedullary nailing (IMN) and 22 with less invasive stabilization system plating. Standing orthoroentgenograms of the lower limbs were taken pre-operatively and at the final follow-up. mLDFA, aLDFA, mechanical axis deviation (MAD) were measured in this orthoroentgenograms. Knee osteoarthritis outcome score (KOOS) and knee range of motion were used pre-operatively and at the final follow-up as part of the evaluation of the clinical results. All patients duration of surgery, length of hospital stay were assessed. Operations were performed by two orthopedic surgeons. The choice of correction method for each patient was determined by the surgeon. Pre-operative and post-operative values were simultaneously measured by two additional orthopedic surgeons. RESULTS: The mean age of the patients was 26.2 years (18.0-51.0) in the plating group and 29.3 years (18.0-55.0) in the nailing group. Patients in the plating and nailing groups were followed up for 24.0 (12.0-60.0) and 27.8 (12.0-60.0) months. All patients were followed for a minimum of 12 months. No significant differences were observed between the groups in terms of age, sex, or duration of follow-up (p > 0.05) Comparison of the pre- and post-operative mLDFA, aLDFA, MAD, length of hospital stay, and duration of surgery between the plating group and nailing group, no significant difference was observed between the groups (p > 0.05). However, patients treated with retrograde IMN had significantly better post-operative results in terms of the KOOS and range of motion of the knee according to plating group (p < 0.05). CONCLUSION: Retrograde IMN does not provide a radiological advantage over the LISS plating technique for valgus deformity but retrograde IMN and correction offered better functional results in cases of femoral valgus deformity than did the LISS plating method.


Subject(s)
Femur/surgery , Fracture Fixation, Internal/methods , Osteotomy/methods , Adolescent , Adult , Bone Malalignment/surgery , Bone Plates , Female , Fracture Fixation, Internal/instrumentation , Fracture Fixation, Intramedullary , Humans , Knee Joint/surgery , Male , Middle Aged , Osteoarthritis, Knee/surgery , Prospective Studies , Young Adult
20.
J Foot Ankle Surg ; 55(3): 504-8, 2016.
Article in English | MEDLINE | ID: mdl-26923689

ABSTRACT

The goal of distal chevron osteotomy for hallux valgus is to restore proper first-toe joint alignment by performing lateral translation of the distal first metatarsal fragment (the metatarsal head). We hypothesized that in some patients this procedure might also result in involuntary medial translation of the proximal first metatarsal fragment, which we called proximal intermetatarsal divergence. The aim of the present study was to compare the pre- and postoperative radiographs of patients with hallux valgus to determine whether we could identify proximal intermetatarsal divergence. We retrospectively compared the pre- and postoperative radiographs of 29 feet in 28 patients treated with distal chevron osteotomy. Two different methods were used to measure the intermetatarsal angles: the anatomic intermetatarsal angle (aIMA) and the mechanical intermetatarsal angle (mIMA). The maximum intermetatarsal distance (MID) was also measured. We defined proximal intermetatarsal divergence as a postoperative increase in the aIMA or MID, coupled with a decrease in the mIMA. For data analysis, we divided the patients into low-angle (mild deformity) and high-angle (severe deformity) groups, according to their preoperative mIMA. The mean ± standard deviation patient age was 41 ± 14 years. In the low-angle group, the mean mIMA decreased (from 10.91° to 7.00°), the mean aIMA increased (from 11.80° to 13.55°), and the mean MID increased (from 17.97 mm to 20.60 mm; p = .001, for all). In the high-angle group, the mean mIMA decreased (from 14.30° to 6.90°; p = .001), the mean aIMA decreased (from 14.77° to 13.54°; p = .06), and the mean MID decreased (from 20.74 mm to 20.37 mm; p = .64). The results of our study suggest that proximal intermetatarsal divergence might occur after distal chevron osteotomy for hallux valgus, primarily in patients with a low preoperative mIMA.


Subject(s)
Hallux Valgus/surgery , Metatarsal Bones/pathology , Osteotomy/methods , Postoperative Complications/diagnostic imaging , Adult , Female , Hallux Valgus/diagnostic imaging , Hallux Valgus/pathology , Humans , Male , Metatarsal Bones/diagnostic imaging , Metatarsal Bones/surgery , Radiography , Retrospective Studies
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