Subject(s)
Appendiceal Neoplasms/diagnostic imaging , Cystadenocarcinoma, Mucinous/diagnostic imaging , Cystadenocarcinoma, Mucinous/secondary , Laparoscopy/adverse effects , Soft Tissue Neoplasms/diagnosis , Soft Tissue Neoplasms/secondary , Surgical Instruments/adverse effects , Abdominal Wall/diagnostic imaging , Abdominal Wall/pathology , Appendiceal Neoplasms/pathology , Appendiceal Neoplasms/surgery , Cicatrix/diagnostic imaging , Cicatrix/etiology , Cicatrix/pathology , Cystadenocarcinoma, Mucinous/etiology , Cystadenocarcinoma, Mucinous/pathology , Cystadenocarcinoma, Mucinous/surgery , Diagnosis, Differential , Female , Fluorodeoxyglucose F18 , Humans , Incidental Findings , Middle Aged , Multimodal Imaging/methods , Positron-Emission Tomography , Radiopharmaceuticals , Soft Tissue Neoplasms/etiology , Tomography, X-Ray ComputedABSTRACT
Erdheim-Chester disease (ECD) is a rare non-Langerhans' cell histiocytosis. Mild but permanent juxta-articular bone pain in mainly knees and ankles is the most frequent associated symptom. Despite the pathognomonic radiographic findings, most cases are still diagnosed by the pathologist.The lesions consist of lipid-storing CD 68 +/CD 1a--non-Langerhans' cell histiocytes, most frequently localized in bone but also involving multiple organ systems in the body. We present a case report in which the diagnosis of ECD was established with 99mTc MDP bone SPECT/CT.
Subject(s)
Bone and Bones/diagnostic imaging , Erdheim-Chester Disease/diagnostic imaging , Radiopharmaceuticals , Technetium Tc 99m Medronate , Tomography, Emission-Computed, Single-Photon/methods , Biopsy , Bone and Bones/pathology , Contrast Media , Diagnosis, Differential , Erdheim-Chester Disease/pathology , Female , Gadolinium , Humans , Magnetic Resonance Imaging/methods , Middle Aged , RadiographySubject(s)
Head and Neck Neoplasms , Hepatitis/diagnosis , Liver/diagnostic imaging , Positron-Emission Tomography/methods , Aged , Biopsy , Contrast Media , Diagnosis, Differential , Female , Fluorodeoxyglucose F18 , Follow-Up Studies , Humans , Liver/pathology , Radiographic Image Enhancement , Radiopharmaceuticals , Tomography, X-Ray Computed/methodsABSTRACT
Gallstone ileus is a rare disease, which is responsible for about 1%-4% of all cases of mechanical obstruction. The findings of gallstone ileus on computed tomography (CT) are pathognomonic. The morbidity and mortality rate remain very high, mainly because of delayed diagnosis. We report a case of gallstone ileus which caused intestinal obstruction which was diagnosed on a contrast-enhanced CT scan of the abdomen.
Subject(s)
Gallstones/diagnostic imaging , Ileus/diagnostic imaging , Intestinal Obstruction/diagnostic imaging , Abdominal Pain/etiology , Aged, 80 and over , Cholecystography/methods , Cholelithiasis/complications , Cholelithiasis/diagnostic imaging , Cholelithiasis/surgery , Contrast Media , Diagnosis, Differential , Female , Follow-Up Studies , Gallbladder/surgery , Gallstones/complications , Gallstones/surgery , Humans , Ileus/complications , Ileus/surgery , Intestinal Obstruction/complications , Intestinal Obstruction/surgery , Radiographic Image Enhancement/methods , Rare Diseases , Tomography, X-Ray Computed/methods , Treatment OutcomeABSTRACT
The (L)-alpha-lyxopyranosyl-(4'-->3')-oligonucleotide system-a member of a pentopyranosyl oligonucleotide family containing a shortened backbone-is capable of cooperative base-pairing and of cross-pairing with DNA and RNA. In contrast, corresponding (D)-beta-ribopyransoyl-(4'-->3')-oligonucleotides do not show base-pairing under similar conditions. We conclude that oligonucleotide systems can violate the 'six-bonds-per-backbone-unit' rule by having five bonds instead, if their vicinally bound phosphodiester bridges can assume an antiperiplanar conformation. An additional structural feature that seems relevant to the cross-pairing capability of the (L)-alpha-lyxopyranosyl-(4'-->3')-oligonucleotide system is its (small) backbone/basepair axes inclination. An inclination which is similar to that in B-DNA seems to be a prerequisite for an oligonucleotide system's capability to cross-pair with DNA.
Subject(s)
Oligoribonucleotides/chemistry , Base Pairing , Chromatography, High Pressure Liquid , Models, Molecular , Nucleic Acid Conformation , Nucleic Acid Denaturation , Oligoribonucleotides/chemical synthesis , Oligoribonucleotides/metabolism , Pentoses , Ribose , Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization , TemperatureABSTRACT
[formula: see text] The L-alpha-lyxopyranosyl (4'-->3') oligonucleotide system shows cooperative base-pairing in spite of containing only five instead of the usual six covalent bonds per repetitive backbone unit. In contrast, corresponding D-beta-ribofuranosyl (4'-->3') oligonucleotides do not show adenine-thymine pairing under comparable conditions. The difference in pairing behavior relates to the conformation of the two systems' vicinal 3',4'-phosphodiester substituents, which is diaxial in the lyxopyranosyl system and 3'-axial-4'-equatorial in the ribopyranosyl system.
