1.
Chem Sci
; 13(41): 12065-12070, 2022 Oct 26.
Article
in English
| MEDLINE
| ID: mdl-36349104
ABSTRACT
Olefin cross-metathesis is a cornerstone reaction in organic synthesis where stereoselectivity is typically governed by the structure of the catalyst. In this work, we show that merging Grubbs second generation catalyst, a classical E-selective catalyst, with a readily available photocatalyst, enables the exclusive formation of the contra-thermodynamic Z-isomer. The scope and limitations of this unprecedented approach are discussed based on both computational and experimental mechanistic data.