Obesity-Status-Linked Affecting Factors of Dyslipidemia in Korean Young-Adult Men: Based on the Korea National Health and Nutrition Examination Survey (2019-2021).

In recent years, there has been a growing trend of obesity and dyslipidemia among young adult men in South Korea. Therefore, we aimed to identify the obesity-related factors of dyslipidemia among young adult men in Korea using 3-year data (2019-2021) from the 8th Korea National Health and Nutrition Examination Survey. We included 1559 eligible men aged 19-39 years and examined the association between dyslipidemia and participants' general characteristics, health-related characteristics, and food intake according to obesity status. Statistical analysis was performed using complex sample analysis with weighted household and individual data. The affecting factors of dyslipidemia included age, body image perception, stress, and waist circumference (WC) in the body mass index (BMI) < 25 kg/m2 group and age and WC in the BMI ≥ 25 kg/m2 group. To prevent and manage dyslipidemia in young adult men, interventions should be developed separately for the normal, underweight, and obese groups. Effective intervention requires measuring WC and focusing on body fat control. Moreover, regular screening of this population should be performed to ensure early diagnosis and management of dyslipidemia.

Effect of Perceived Stress on Health-Related Quality of Life among Primary Caregiving Spouses of Patients with Severe Dementia: The Mediating Role of Depression and Sleep Quality.

Recently, there has been a rise in the number of spouses becoming primary caregivers to patients with dementia. This study identifies the mediating effects of depression and sleep quality on the relationship between perceived stress and health-related quality of life (HRQoL) among primary caregiving spouses of patients with severe dementia through a secondary data analysis of the 2018 Korea Community Health Survey by the Korea Disease Control and Prevention Agency. Data from 229 primary caregiving spouses of patients with severe dementia were analyzed using descriptive statistics, Spearman's rank correlation or Pearson's correlation analysis, and the lavaan R package, version 0.6-9. The association between perceived stress status (PSS) and the European Quality of Life Five Dimension (EQ-5D) index was highly significant. The direct effect of PSS observed in the model was nullified with both the Patient Health Questionnaire-9 and the Pittsburgh Sleep Quality Index as mediators, which implies that they mediate the effect of PSS on caregivers' EQ-5D indexes. The mediation model accounted for 33.2% of the variance in the EQ-5D index of caregivers. The results suggest the need to develop an intervention to improve sleep quality and manage depression to mitigate a decline in HRQoL for these caregivers.

Predictors of Cognitive Function in Community-Dwelling Older Adults by Age Group: Based on the 2017 National Survey of Older Korean Adults.

Owing to a growing older adult population, dementia is emerging as an important health issue. Given that maintaining cognitive functions is crucial for the prevention of dementia, this study aimed to identify the predictors of cognitive function in community-dwelling older adults, through a secondary data analysis of the 2017 National Survey of Older Koreans. A total of 9836 participants were classified into three age groups-young-old (65-74 years), old-old (75-84 years), and oldest-old (≥85 years)-and were separately analyzed using multiple linear regression models. The final model explained 28.0%, 35.0%, and 37.0% of variance in cognitive function in the three age groups, respectively. The most potent predictors of cognitive function in the young-old were electronic device-based activities, instrumental activities of daily living (IADL), and nutrition management; the predictors for the old-old group were electronic device-based activities, IADL, and dementia screening, and those for the oldest-old group were frequency of contact with acquaintances, traveling, and religion. Thus, age group-specific interventions are needed to effectively promote cognitive function among older adults. Digital literacy education, use of community-based elderly welfare programs, opportunities for social interactions, and physical activities can help older adults in maintaining a functional status and muscle strengthening.

Characterizing the highest tropical cyclone frequency in the Western North Pacific since 1984.

The 2018 boreal summer in the Western North Pacific (WNP) is highlighted by 17 tropical cyclones (TC)-the highest record during the reported reliable years of TC observations. We contribute to the existing knowledge pool on this extreme TC frequency record by showing that the simultaneous highest recorded intensity of the WNP summer monsoon prompted the eastward extension of the monsoon trough and enhancement of tropical convective activities, which are both favorable for TC development. Such changes in the WNP summer monsoon environment led to the extreme TC frequency record during the 2018 boreal summer. Meanwhile, the highest record in TC frequency and the intensity of the WNP summer monsoon are both attributed with the combined increase in the anomalous westerlies originating from the cold tropical Indian Ocean sea surface temperature (SST) anomalies drawn towards the convective heat source that is associated with the warm central Pacific SST anomalies. Our results provide additional insights in characterizing above normal tropical cyclone and summer monsoon activities in the WNP in understanding seasonal predictable horizons in the WNP, and in support of disaster risk and impact reduction.

E1A physically interacts with RUNX3 and inhibits its transactivation activity.

The adenoviral gene, termed early region 1A (E1A), is crucial for transformation and has been used very effectively as a tool to determine the molecular mechanisms that underlie the basis of cellular transformation. pRb, p107, p130, p300/CBP, p400, TRRAP, and CtBP were identified to be E1A-binding proteins and their roles in cellular transformation have been established. Although the major function of E1A is considered to be the regulation of gene expression that is critical for differentiation and cell cycle exit, one of the most significant questions relating to E1A transformation is how E1A mediates this regulation. RUNX3 is a transcription factor that was first described as a gastric cancer tumor suppressor but is now known to be involved in many different cancers. Exogenous expression of RUNX3 strongly inhibits the growth of cells. Here, we show that the adenovirus oncoprotein E1A interacts with RUNX3 in vitro and in vivo. RUNX3 interacts with the N-terminus (amino acids 2-29) of E1A, which is known to interact with p300/CBP, p400, and TRRAP. E1A interacts directly with the Runt domain of RUNX3 but does not interfere with CBFbeta-RUNX3 interactions. In addition, E1A inhibits the transactivation activity of RUNX3 on the p21(WAF1/CIP1) promoter. Consistent with these observations, the growth inhibition induced by RUNX3 is reduced by E1A. These results demonstrate that E1A specifically binds to RUNX3 and inactivates its transactivation activity. We propose that one of the mechanisms for the oncogenic activity of E1A is the inhibition of RUNX3, similar to that of RB and p300/CBP.

[The lived experience of a student transferring into the nursing program].

PURPOSE: This study attempted to describe the essential structure of the lived experience of a students transferring into the nursing program. METHOD: The data was collected from 14 graduates and undergraduates who enrolled in nursing school as transfer students. The analysis of the data was made by phenominological analytic method suggested by Colaizzi(1978). RESULT: In this study, 6 essential themes were extracted: 'Constant anxiety of being a stranger', 'Feeling of constant burden', 'Thankfulness of a clinical practice group', 'Being supportive with each other between transferring students', 'Pleasure of studying a desired major', 'Feeling the responsibility of own choice of a new major'. CONCLUSION: With rapidly increasing number of transferring students, the significance of this study in the field of nursing is that by understanding the transferring experience of nursing students, it describes the need of systematic and emotional support for transferring students.