Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Cancer ; 97(9): 2203-11, 2003 May 01.
Article in English | MEDLINE | ID: mdl-12712472

ABSTRACT

BACKGROUND: There is a statistically significant association between human leukocyte antigen (HLA) Class I antigen expression and improved prognosis for some patients. This association reflects the control of tumor growth by HLA Class I antigen-restricted, tumor-associated antigen-specific cytolytic T cells. However, progression of other malignant diseases is not associated with the loss of HLA expression. These observations show that the poor prognosis of a subset of tumors, despite high HLA Class I antigen expression, may reflect the development of alternative mechanisms utilized by tumor cells to escape from immune recognition and destruction. METHODS: The authors evaluated the possible correlation between the expression of the antiapoptosis gene, Survivin, HLA Class I, and progression of tonsillar squamous cell carcinomas (TSCC) lesions. Tissue microarrays were constructed from primary TSCC, metastatically involved lymph nodes, adjacent normal mucosa, and tonsillar parenchyma excised for nonmalignant conditions. RESULTS: Immunoperoxidase staining of tissue sections demonstrated that Survivin expression is significantly higher (P < 0.001) in malignant tumors than in normal tissue samples. In addition, Survivin expression is significantly higher (P = 0.05) in metastatic than in primary lesions. Survivin expression in primary lesions correlated positively with delta (P = 0.025), tapasin (P = 0.028), and HLA Class I antigen (P = 0.006) expression. The expression patterns of delta, tapasin, HLA Class I antigen, beta-2-microglobulin, and Survivin did not demonstrate any significant association with the clinical course of disease. CONCLUSIONS: For TSCC that maintain the expression of HLA Class I antigen, overexpression of Survivin may provide an alternative explanation for tumor progression.


Subject(s)
Carcinoma, Squamous Cell/metabolism , Histocompatibility Antigens Class I/metabolism , Microtubule-Associated Proteins/metabolism , Tonsillar Neoplasms/metabolism , Antigen Presentation/physiology , Antiporters/metabolism , Carcinoma, Squamous Cell/pathology , Carcinoma, Squamous Cell/therapy , Case-Control Studies , Female , Follow-Up Studies , Gene Expression Regulation, Neoplastic , Homeodomain Proteins/metabolism , Humans , Immunoenzyme Techniques , Immunoglobulins/metabolism , Inhibitor of Apoptosis Proteins , Intracellular Signaling Peptides and Proteins , Male , Membrane Proteins/metabolism , Membrane Transport Proteins , Middle Aged , Neoplasm Proteins , Neoplasm Staging , Survivin , Tonsillar Neoplasms/pathology , Tonsillar Neoplasms/therapy , beta 2-Microglobulin/metabolism
SELECTION OF CITATIONS
SEARCH DETAIL
...