Subject(s)
Chickenpox/congenital , Chickenpox/prevention & control , Pregnancy Complications, Infectious/prevention & control , Chickenpox/diagnosis , Chickenpox Vaccine , Female , Humans , Infant, Newborn , Infectious Disease Transmission, Vertical , Pregnancy , Pregnancy Complications, Infectious/diagnosisSubject(s)
Fetal Alcohol Spectrum Disorders , Kidney/abnormalities , Female , France , Humans , Infant, Newborn , Pregnancy , Umbilical Arteries/abnormalitiesSubject(s)
Morphine/administration & dosage , Narcotics/administration & dosage , Narcotics/adverse effects , Neonatal Abstinence Syndrome/drug therapy , Diazepam/administration & dosage , Drug Combinations , Female , Humans , Hypnotics and Sedatives/administration & dosage , Infant, Newborn , Neonatal Abstinence Syndrome/etiology , Opioid-Related Disorders/complications , Pregnancy , Pregnancy Complications/diagnosis , Treatment OutcomeSubject(s)
Breast Feeding , Infant, Premature , Child, Hospitalized , Humans , Infant , Infant, NewbornABSTRACT
We describe two cases of congenital varicella. The first presented with cutaneous aplasia and scars; the second with skin abnormalities, limb atrophy, limb paresis, Horner's syndrome and liver calcifications: prognosis was poor in this case. After reviewing the published cases of congenital varicella, we advocate the use of varicella vaccine in seronegative women before pregnancy.
Subject(s)
Chickenpox/congenital , Chickenpox/complications , Chickenpox/prevention & control , Chickenpox Vaccine , Female , Humans , Infant, Newborn , MaleSubject(s)
Acquired Immunodeficiency Syndrome/drug therapy , Anti-HIV Agents/adverse effects , Cholestasis/chemically induced , Thrombocytosis/chemically induced , Zidovudine/adverse effects , Anti-HIV Agents/therapeutic use , Female , Humans , Infant, Newborn , Infant, Newborn, Diseases , Zidovudine/therapeutic useSubject(s)
Ammonia/blood , Anticonvulsants/adverse effects , Hypoglycemia/chemically induced , Thrombocytopenia/chemically induced , Valproic Acid/adverse effects , Adult , Anticonvulsants/therapeutic use , Female , Humans , Infant, Newborn , Infant, Newborn, Diseases/chemically induced , Male , Maternal-Fetal Exchange , Pregnancy , Pregnancy Complications/drug therapy , Valproic Acid/therapeutic useABSTRACT
UNLABELLED: Metopic craniosynostosis may be an adverse effect of valproic acid exposed fetus. CASES: We report two infants with metopic craniosynostosis, born to mothers who were treated with valproic acid. In one case, a prenatal diagnosis was made. In the other case, only the male dizygotic twin was affected. CONCLUSION: Trigonocephaly may be a symptom of valproate embryofoetopathy detectable by antenatal ultrasound examination.
Subject(s)
Abnormalities, Drug-Induced/etiology , Craniosynostoses/chemically induced , Epilepsy, Generalized/drug therapy , Pregnancy Complications/drug therapy , Valproic Acid/adverse effects , Abnormalities, Drug-Induced/diagnosis , Craniosynostoses/diagnosis , Diseases in Twins , Female , Humans , Imaging, Three-Dimensional , Infant, Newborn , Male , Pregnancy , Tomography, X-Ray Computed , Twins, Dizygotic , Ultrasonography, Prenatal , Valproic Acid/therapeutic useSubject(s)
Blepharitis/pathology , Eyelid Diseases/parasitology , Filariasis/pathology , Blepharitis/etiology , Female , Humans , InfantABSTRACT
UNLABELLED: Drug administration during the last trimester of pregnancy may have adverse effects for the newborn. CASE REPORT: A hemolytic anemia occurred during the first hours of life in a full-term neonate whose mother had taken nitrofurantoin during the last month of pregnancy. CONCLUSION: The immature enzymatic systems of the neonate are exposed to this adverse effect and justify the recommendation not to prescribe nitrofurantoin at the end of pregnancy.
Subject(s)
Anemia, Hemolytic/chemically induced , Anti-Infective Agents, Urinary/adverse effects , Infant, Newborn, Diseases/chemically induced , Nitrofurantoin/adverse effects , Adult , Anti-Infective Agents, Urinary/administration & dosage , Female , Humans , Infant, Newborn , Male , Maternal-Fetal Exchange , Nitrofurantoin/administration & dosage , Pregnancy , Pregnancy Complications, Infectious/drug therapy , Pregnancy Trimester, Third , Urinary Tract Infections/drug therapyABSTRACT
UNLABELLED: The association of aplasia cutis congenita and aortic coarctation could be a coincidence. CASE REPORT: A neonate was born with an aplasia cutis congenita in the midline of the scalp. When she was two months old, an aortie coarctation was detected and surgically resected. Spontaneously, the scalp gradually cicatrized. CONCLUSION: A search for a candidate gene in this second reported case is mandated.
Subject(s)
Aortic Coarctation/complications , Ectodermal Dysplasia/complications , Aortic Coarctation/genetics , Aortic Coarctation/pathology , Ectodermal Dysplasia/genetics , Ectodermal Dysplasia/pathology , Female , Genetic Predisposition to Disease , Humans , Infant, NewbornSubject(s)
Anti-Infective Agents/adverse effects , Fever/drug therapy , Maternal-Fetal Exchange , Neutropenia/chemically induced , Pregnancy Complications/drug therapy , Trimethoprim, Sulfamethoxazole Drug Combination/adverse effects , Female , Humans , Infant, Newborn , Leukocyte Count , Neutropenia/blood , Pregnancy , Pregnancy Trimester, ThirdABSTRACT
BACKGROUND: Neonatal myoclonic encephalopathy is of lesional or metabolic origin; non ketotic hyperglycinemia is one of its causes. CASE REPORT: A girl, born from consanguineous parents, died from myoclonic epileptic encephalopathy at the age of 3 months. Screening for metabolic disease was negative, except for increased levels of urine serotonin and 5-hydroxyindol-acetic in cerebrospinal fluid, blood and urine. Two sisters died with non ketotic hyperglycinemia, corpus callosum agenesis and clubfoot. CONCLUSION: Familial occurrence of non ketotic hyperglycinemia and early myoclonic epileptic encephalopathy is uncommon.
Subject(s)
Consanguinity , Epilepsies, Myoclonic/genetics , Hyperglycemia/genetics , Electroencephalography , Epilepsies, Myoclonic/congenital , Epilepsies, Myoclonic/physiopathology , Female , Humans , Hyperglycemia/congenital , Hyperglycemia/physiopathology , Infant, Newborn , MaleABSTRACT
UNLABELLED: Hypoglossia is a rare malformation that is not fatal, unlike otocephaly. CASE REPORT: A neonate, born at 39 weeks of GA and dead at 5th day showed hypoglossia, dextrocardia, situs inversus and pituitary aplasia. Maternal hyperthermia was observed at 4 weeks gestation. CONCLUSION: This case is reminiscent of a community of syndrome with agnathia-holoprosencephaly and situs inversus. The responsibility of maternal hyperthermia is raised.
Subject(s)
Congenital Abnormalities/etiology , Fever , Pituitary Gland/abnormalities , Pregnancy Complications , Situs Inversus/complications , Tongue/abnormalities , Adult , Fatal Outcome , Female , Humans , Infant, Newborn , Male , Pregnancy , Situs Inversus/etiologyABSTRACT
Balanced chromosomal abnormalities such as translocations and inversions have been identified in many genetic diseases. Cloning of the breakpoints involved in these abnormalities has led to the identification of the disease-related genes. Recent reports suggest the presence of a mental retardation locus at Xq11-12. We have identified a female patient with a balanced translocation t (X;12) (q11;q15) associated with mild mental retardation. We identified a yeast artificial chromosome spanning the X-chromosome breakpoint by using fluorescent in situ hybridization techniques. A cosmid library of this YAC has been constructed and the search for candidate genes is in progress.