ABSTRACT
BACKGROUND: Oral health is an essential component of health throughout life. Two major oral diseases, dental caries and periodontal diseases, are both ancient and widespread. The oral health situation analysis demands that the preventive program be implemented in both the developing and developed countries. Therefore, this study was conducted to evaluate the effectiveness of delivering the primary preventive strategies through non dental and dental personnel. AIMS AND OBJECTIVES: To develops the preventive package for improving the oral health status of children utilizing the different communication approaches. To find out the most feasible and effective communication approach for delivering the preventive package. To evaluate the changes produced in terms of various soft and hard core parameters after 6 months of implementation of the oral-health preventive package in the school children of different study groups as compared to control. MATERIALS AND METHODS: This study was conducted on total of 972 children in the age group of 5-16 years who were randomly selected from four schools of Chandigarh and Panchkula to evaluate and compare the prevalence of dental caries and knowledge, attitude, and practice about oral health. RESULTS AND CONCLUSIONS: The results of various parameters indicate that direct communication through the dentist proved to be the most effective communication approach as compared to the other two indirect communication approaches.
Subject(s)
Health Education, Dental/methods , Oral Health , Adolescent , Attitude to Health , Cariogenic Agents/adverse effects , Cariostatic Agents/therapeutic use , Child , Child, Preschool , Communication , DMF Index , Dental Caries/prevention & control , Dental Plaque/prevention & control , Dentist-Patient Relations , Dietary Sucrose/administration & dosage , Dietary Sucrose/adverse effects , Feasibility Studies , Follow-Up Studies , Health Knowledge, Attitudes, Practice , Humans , India , Mouthwashes/therapeutic use , Periodontal Diseases/prevention & control , Primary Prevention/methods , Sodium Fluoride/therapeutic use , Teaching/methods , Teaching Materials , ToothbrushingABSTRACT
Myc, a key regulator of cellular proliferation, differentiation and apoptosis, exerts its biological functions by activating or suppressing the transcription of specific sets of target genes. C/EBP transcription factors play important roles during differentiation of various cell types and have been identified as critical targets for v-Myc- and c-Myc-dependent suppression of myeloid and fat cell differentiation. Here, we have addressed the mechanism by which v-Myc suppresses the activity of C/EBPbeta. We show that v-Myc is recruited to the aminoterminal domain of C/EBPbeta and interferes with the cooperation of C/EBPbeta and the co-activator p300 by preventing C/EBPbeta-induced phosphorylation of p300. We have identified the protein kinase responsible for C/EBPbeta-induced phosphorylation of p300 as homeo-domain interacting protein kinase 2 (HIPK2) and show that v-Myc displaces the kinase from the C/EBPbeta-p300 complex. Overall, our findings that the modulation of the C/EBPbeta-induced phosphorylation of p300 as a new mechanism of transcriptional suppression by v-Myc.
