ABSTRACT
Changes in the contents of adenine nucleotides, creatine phosphate, inorganic phosphate, creatine, glucose-6-phosphate and glycogen and the activity of adenylate cyclase, creatine kinase, glycogen phosphorylase 31:51-AMP-phosphodiesterase and glycogen synthetase in muscles and of blood catecholamines were studied in adult rats before loading, immediately after the cessation of the muscular activity, and at rest. Adenine nucleotides are established to play a regulatory role in catabolic and anabolic processes nucleotides are established to play a regulatory role in catabolic and anabolic processes related to the muscular activity. It is established that compensation and supercompensation of the working losses of muscular creatine phosphate and glycogen are due to activation of anabolic processes under conditions of higher phosphorylation of the adenylic system.
Subject(s)
Adenine Nucleotides/metabolism , Creatine Kinase/metabolism , Cyclic AMP/metabolism , Glycogen Synthase/metabolism , Muscles/metabolism , 3',5'-Cyclic-AMP Phosphodiesterases/metabolism , Animals , Creatine/metabolism , Glucosephosphates/metabolism , Glycogen/metabolism , Phosphates/metabolism , Phosphocreatine/metabolism , Phosphorylation , RatsSubject(s)
Homeostasis , Physical Exertion , Sports Medicine , Adaptation, Physiological , Adult , Animals , Creatine/metabolism , Glycogen/metabolism , Heart Rate , Humans , Lactates/blood , Male , Muscles/metabolism , Myocardium/metabolism , Rats , RestABSTRACT
Unilateral transection and partial resection of the sciatic nerve after intensive muscular activity entail changes in the biochemical restitution processes in both denervated and contralateral intact muscles. The data obtained reveal the obvious metabolic changes in muscle fibers due to nervous deprivation.
Subject(s)
Muscle Denervation , Muscles/metabolism , Physical Exertion , Animals , Glycogen/metabolism , Lactates/metabolism , Male , Phosphocreatine/metabolism , Rats , Rest , Time FactorsABSTRACT
Metabolic changes during intense muscular activity and the work efficiency depend on the prestart biochemical changes. Excessiveness of these changes or, particularly, their absence decrease the work capacity. Character of the prestart reaction depends on the grade of adaptation of the organism to muscular activity; favourable, moderate prestart biochemical changes are characteristic o highly trained sportsmen. Disturbed ATP balance in the working muscles was found not to be always a limiting factor for the work capacity.
