ABSTRACT
We studied the effect of peptide drugs deltalicin and Semax on lipid metabolism disturbances in diabetes mellitus. Diabetes mellitus was modeled by single injection of streptozotocin (45 mg/kg) and rats with blood glucose ≥12 mmol/liter were selected for the further experiments. Deltalicin in a dose 100 µg/kg and Semax in a dose 200 µg/kg as well as sulodexide corrected lipid metabolism disorders: the content of total cholesterol, triglycerides, LDL, index of atherogenicity decreased and HDL concentration increased. Deltalicin produced more potent effect on lipid metabolism in rats with diabetes mellitus than sulodexide and Semax, which manifested in a significant decrease in total cholesterol and LDL concentration and index of atherogenicity.
Subject(s)
Diabetes Mellitus, Experimental/drug therapy , Hypolipidemic Agents/therapeutic use , Lipid Metabolism Disorders/drug therapy , Peptides/therapeutic use , Adrenocorticotropic Hormone/analogs & derivatives , Adrenocorticotropic Hormone/therapeutic use , Animals , Diabetes Mellitus, Experimental/chemically induced , Diabetes Mellitus, Experimental/complications , Diabetes Mellitus, Experimental/metabolism , Glycosaminoglycans/pharmacology , Glycosaminoglycans/therapeutic use , Lipid Metabolism/drug effects , Lipid Metabolism Disorders/complications , Male , Peptide Fragments/therapeutic use , Rats , Rats, Wistar , StreptozocinABSTRACT
We studied the influence of synthetic indolicidin analogues on the development of acute periodontitis. The corrective effect was found in indolicidin analogues Nos. 7 and 8; it manifested in a decrease in the edema of gingival epithelium and lamina propria, a decrease in the relative area of inflammatory infiltrates, and a significant increase in the relative area of normal connective tissue. These changes were revealed as soon as on day 14 and were most pronounced in 21 days after the removal of the ligature. Indolicidin analogues Nos. 7 and 8 demonstrated similar effectiveness on the model of acute periodontitis.
