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J Nat Prod ; 69(2): 305-7, 2006 Feb.
Article in English | MEDLINE | ID: mdl-16499340

ABSTRACT

A new cycloheptapeptide, cordyheptapeptide A (1), was isolated from the insect pathogenic fungus Cordyceps sp. BCC 1788 along with four known bioxanthracenes (2-5). The structure was elucidated by spectroscopic data. The absolute configuration of amino acid residues was determined by HPLC and X-ray diffraction analyses.


Subject(s)
Antimalarials/isolation & purification , Cordyceps/chemistry , Peptides, Cyclic/isolation & purification , Animals , Antimalarials/chemistry , Antimalarials/pharmacology , Artemisinins/pharmacology , Chlorocebus aethiops , Chromatography, High Pressure Liquid , Coleoptera , Crystallography, X-Ray , Inhibitory Concentration 50 , Larva , Molecular Structure , Peptides, Cyclic/chemistry , Peptides, Cyclic/pharmacology , Plasmodium falciparum/drug effects , Protein Conformation , Sesquiterpenes/pharmacology , Thailand , Vero Cells
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