[Comprehensive approach to the evaluation of psychophysiological status in man]. / Kompleksnyi pidkhid do otsinky psykhofiziolohichnoho stanu liudyny.

Psychophysiological rating (PR) as an integral index of the human cognitive level has been evaluated in 95 pupils from senior classes using a set of 8 psychophysiological parameters (QI, two indices of strength of the nervous system, functional mobility of the nervous processes, brain efficiency, speed and quality of analytical, logical and imagine mentality) determined by means of original computer programs. PR correlated with teaching efficiency (r = 0.535). It is offered to use PR for estimation of human cognitive level and professional selection.

[The dependence of the achievement of students on the individual typological properties of their nervous systems]. / Zavisimost' uspevaemosti studentov ot individual'no-tipologicheskikh svoistv ikh nervnoi sistemy.

A reliable correlation (r = 0.47) between cognitive ability and educational achievement has been determined in 195 students (men and women) aged 21-25. Progress in studies depends also on such individual-typological properties as "strength" of the excitation process (r = 0.46), work reliability (r = 0.49) and functional "mobility" of the nervous brain process (r = 0.38). On the whole, teaching efficiency is determined by a complex of psychophysiological state indices rather than by one of these indices.

[Analysis of the process of learning in the formation of the conditioned reflex of avoidance in rats]. / Analiz protsessa obucheniia pri formirovanii uslovnogo refleksa izbeganiia u krys.

During acquisition of avoidance conditioned reflex (CR) in shuttle box by electric shock it is shown that the performance of that defence reaction is induced by the joint action of two factors: general arousal of animals and motivation. Motor activity of rats in an "open field", the number of short-latency (2s) and intersignal responses during formation of the avoidance CR are in index of the general arousal of rats. An artificial increase in the general arousal of animals by caffeine induces acceleration of CR performance. A constant level of the general arousal of rats is one of the reasons that oxytocin does not influence the rate and dynamics of the avoidance CR performance in rats.

[The evaluation and prognosis of the psychophysiological status of a human operator]. / Otsenka i prognozirovanie psikhofiziologicheskogo sostoianiia cheloveka-operatora.

In experiments on 56 healthy subjects (18-20 years old) the quality of their activity was determined during compensatory watching the mark at complicating regimes of work. Depending on the difficulty of the task five groups of subjects were singled out with optimum working capacity in one of four working conditions: normal, ordinary and strenuous work, model of stress situation. It is established that the change of the number of significant correlative connections between main parameters of psychophysiological state of man-operator reflects the condition of his functional systems. On the basis of computation of total range of organization values of both R-R intervals of the ECG and duration of expiration, the success of the man-operator work in complex conditions of activity is predicted.

[Effect of destruction of the septum and hippocampus on the shuttle-box avoidance conditioning of the rat]. / Vliianie razrushenii peregorodki i gippokampa na osushchestvlenie chelnochnykh refleksov izbeganiia u krys.

Total destruction of the septum, the dorsal hippocampus (DH), or the lesion of the DH combined with that of the medial septal nucleus in rats was shown to facilitate elaboration of conditioned avoidance responses in a shuttle-box due to an increase of general excitability of the animals, and to cause significant impairment of internal inhibition formation. Lesions of the medial or the lateral septal nuclei as well as a combined lesion of the DH and the lateral septal nucleus had no significant effect on conditioning and internal inhibition elaboration. Therefore the septo-hippocampal connections had different functional directions during active defensive behaviour.

[Functional role of the dorsal and ventral hippocampus in defensive behavior in the rat]. / Funktsional'naia rol' dorzal'nogo i ventral'nogo gippokampa v oboronitel'nom povedenii krys.

Bilateral electrolytic lesions of the dorsal hippocampus of white rats were shown to facilitate elaboration of a conditioned response of active avoidance of pain shock in a shuttle-box. The lesions of the ventral hippocampus had no effect on conditioning. The ventral hippocampal lesions led to a complete failure to form differential inhibition. In rats with the dorsal hippocampal lesions an acquisition of partial (up to 60 per cent) discrimination of stimuli was possible. The differences in avoidance conditioning and elaboration of differential inhibition in rats with the dorsal and ventral hippocampal lesions are supposed to be caused by the changes of general excitability and emotional state of animals as well as by a specific role of the ventral hippocampus in memory consolidation.

[Role of amygdalar nuclei in alimentary and defensive conditioned reflexes in the rat]. / Rol' iader mindaliny v pishchevykh i oboronitel'nykh uslovnykh refleksakh u krys.

Ninety experimentally naive male white rats were divided into groups with lateral (AL), medial (AME) and central (ACE) amygdalar nuclei lesions, sham-operated and normal controls. The AL-rats showed a facilitation of instrumental conditioned alimentary reflexes (CAR) acquisition and retardation of initial avoidance learning in a shuttle box; the AME-rats exhibited a slower acquisition of the CAR and a facilitation of avoidance conditioning; in the ACE-rats acquisition of the CAR was the same as in controls but avoidance performance was significantly impaired as compared with all experimental groups. It has been assumed that functional non-identity of the amygdalar nuclei in alimentary and avoidance behaviour is caused by dominant drive and by presence of "specific" amygdalar neurones participating in functional systems of the studied behavioural reactions.

[Internal inhibition in rats after destruction of amygdaloid complex nuclei]. / Vnutrennee tormozhenie u krys pri razrushenii iader mindalevidnogo kompleksa.

In experiments on male albino rats bilateral lesions of the basolateral amygdala (BLA) impaired extinction and differentiation of the food-procuring conditioned reflexes where as bilateral corticomedial (CMA) lesions had no effect on them. The BLA damage caused a significant impairment of the aversive stimuli discrimination but had no effect on the extinction of the conditioned avoidance reflex in a shuttle-box. The CMA lesions in both hemispheres led to attenuation of aversive stimuli discrimination and delay of avoidance extinction. The data obtained testify to the BLA dominant role in internal inhibition of the alimentary conditioned reflexes and the CMA dominant role in internal inhibition of avoidance conditioning and furthermore to the importance of BLA in the evaluation of the emotional significance and biological validity of the stimuli (reward or punishment).

[Effect of destruction of the basolateral portion and medial nuclei of the amygdaloid complex on defensive conditioned reflexes in rats]. / Vliianie razrusheniia bazolateral'noi chasti i medial'nykh iader mindalevidnogo kompleksa na oboronitel'nye uslovnye refleksy u krys.

Bilateral ablations of the basolateral part and medial nuclei of the amygdala in albino rats caused opposite changes in active avoidance acquisition and consolidation, emotional intensity level (fear) and "open field" activity. In intact animals the basolateral part of the amygdala produced facilitation while medial nuclei caused inhibition of the shuttlebox avoidance reactions, aggressiveness and general "emotionality" (fear-motivated behaviour).