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Bioorg Med Chem Lett ; 15(10): 2679-84, 2005 May 16.
Article in English | MEDLINE | ID: mdl-15863341

ABSTRACT

We describe the synthesis and structure/activity relationship of RGD mimetics that are potent inhibitors of the integrin alpha(v)beta3. Indol-1-yl propionic acids containing a variety of basic moieties at the 5-position, as well as substitutions alpha and beta to the carboxy terminus were synthesized and evaluated. Novel compounds with improved potency have been identified.


Subject(s)
Integrin alphaVbeta3/antagonists & inhibitors , Propionates/pharmacology , Indoles/chemistry , Molecular Mimicry , Oligopeptides/chemistry , Propionates/chemistry , Structure-Activity Relationship
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