Subject(s)
Arginine/administration & dosage , Erythropoietin/toxicity , Hypertension, Renal/chemically induced , Nephrectomy , Administration, Oral , Animals , Blood Pressure/drug effects , Hypertension, Renal/pathology , Hypertension, Renal/physiopathology , Male , Rats , Rats, Wistar , Recombinant Proteins/toxicityABSTRACT
1. There is no experimental proof that renal insufficiency is a necessary condition for hypertension during erythropoietin treatment. 2. The present study compares the effect of 3 weeks treatment with r-hu EPO (50 i.u./kg) on systolic blood pressure (SBP), haematocrit and plasma cGMP in an animal model of chronic renal failure (remnant kidney model excision) and sham-operated rats. 3. Sub-total nephrectomy induced a significant fall in haematocrit and a significant increase in plasma creatinine levels. Treatment with r-hu EPO resulted in a significant haematocrit increase in uraemic as well as in non-uraemic rats. Despite this effect, r-hu EPO treatment had no effect on SBP in sham-operated rats. On the contrary, this treatment caused significant SBP elevation in uraemic rats; in these rats, SBP increase did not correlate with haematocrit increase. 4. Plasma cGMP concentrations were significantly higher in uraemic compared to sham-operated rats and were not modified by r-hu EPO treatment. 5. This study provides evidence that renal insufficiency in rats is a prerequisite for the development of hypertension during erythropoietin treatment.
Subject(s)
Blood Pressure/drug effects , Erythropoietin/adverse effects , Hypertension/chemically induced , Kidney Failure, Chronic/complications , Uremia/complications , Animals , Blood Pressure/physiology , Creatinine/blood , Cyclic GMP/blood , Disease Models, Animal , Erythropoietin/administration & dosage , Hematocrit , Hypertension/blood , Hypertension/etiology , Kidney Failure, Chronic/blood , Male , Nephrectomy , Rats , Rats, Wistar , Uremia/bloodABSTRACT
The effects on the crab's respiration of the sublethal metallic concentrations are analysed upon in toto organic structures and upon their very sensitive organs in the best and stressing conditions of temperature and of salinity. There is a connection between the metallic concentrations causing respiration deteriorations and the bearable metallic concentrations (starting lethal thresholds). In the same way there is a good correlation between the level of bioaccumulation and the metabolic depletion of the tissues. It's well proved by this research that a lethal metallic concentration in the best conditions of temperature and of salinity can greatly reduce the ability of the population to survive in the natural conditions of thermic and salin stress.
