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J Biol Chem ; 291(45): 23506-23515, 2016 Nov 04.
Article in English | MEDLINE | ID: mdl-27590337

ABSTRACT

Riboflavin is a common cofactor, and its biosynthetic pathway is well characterized. However, its catabolic pathway, despite intriguing hints in a few distinct organisms, has never been established. This article describes the isolation of a Microbacterium maritypicum riboflavin catabolic strain, and the cloning of the riboflavin catabolic genes. RcaA, RcaB, RcaD, and RcaE were overexpressed and biochemically characterized as riboflavin kinase, riboflavin reductase, ribokinase, and riboflavin hydrolase, respectively. Based on these activities, a pathway for riboflavin catabolism is proposed.


Subject(s)
Actinomycetales/enzymology , Actinomycetales/genetics , Multigene Family , Riboflavin/genetics , Actinomycetales/metabolism , Bacterial Proteins/genetics , Bacterial Proteins/metabolism , FMN Reductase/genetics , FMN Reductase/metabolism , Genes, Bacterial , Hydrolases/genetics , Hydrolases/metabolism , Phosphotransferases (Alcohol Group Acceptor)/genetics , Phosphotransferases (Alcohol Group Acceptor)/metabolism , Riboflavin/metabolism
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