Subject(s)
Carcinoma, Squamous Cell , Macular Degeneration , Paraneoplastic Syndromes, Ocular , Retinal Diseases , Carcinoma, Squamous Cell/complications , Carcinoma, Squamous Cell/diagnosis , Humans , Lip/pathology , Paraneoplastic Syndromes, Ocular/diagnosis , Paraneoplastic Syndromes, Ocular/etiology , Paraneoplastic Syndromes, Ocular/pathologySubject(s)
Choroid/blood supply , Ischemia/etiology , Pre-Eclampsia/physiopathology , Pregnancy Complications, Cardiovascular/etiology , Choroid/diagnostic imaging , Female , Fluorescein Angiography , Humans , Ischemia/diagnostic imaging , Pregnancy , Pregnancy Complications, Cardiovascular/diagnostic imaging , Young AdultSubject(s)
Corneal Ulcer/diagnosis , Deafness/diagnosis , Ichthyosis/diagnosis , Keratitis/diagnosis , Aged , Corneal Ulcer/complications , Corneal Ulcer/pathology , Diagnosis, Differential , Eyelid Diseases/complications , Eyelid Diseases/diagnosis , Eyelid Diseases/pathology , Humans , Male , Meibomian Glands/pathology , RecurrenceABSTRACT
Suriclone is a novel cyclopyrrolone exhibiting anxiolytic activity. Twelve healthy Caucasian male volunteers participated in the study. A single dose of suriclone 0.4 mg, imipramine 75 mg, suriclone 0.4 mg + imipramine 75 mg, or placebo was given according to a 4 x 4 Latin-square design in order to assess the effect of drug association on pharmacokinetics and psychomotor performances. Visual analogue scale ratings, critical flicker frequency, choice visual reaction time, and Pauli, picture memory and Sternberg tests were performed before and 1.5, 6 and 9 h after drug administration. Suriclone, with the exception of the Pauli test, had no effect on psychomotor performances. The imipramine-suriclone association appeared to disturb some performances (no statistical significance), probably due to the effect of imipramine. Blood samples were collected for determination of imipramine and suriclone plasma levels respectively by high-performance liquid chromatography and radioimmunoassays. Suriclone AUC, Cmax and Tmax were not affected by imipramine, and reciprocally.
Subject(s)
Anti-Anxiety Agents/pharmacology , Anti-Anxiety Agents/pharmacokinetics , Imipramine/pharmacology , Imipramine/pharmacokinetics , Piperazines/pharmacology , Piperazines/pharmacokinetics , Psychomotor Performance/drug effects , Adult , Chromatography, High Pressure Liquid , Double-Blind Method , Drug Interactions , Flicker Fusion/drug effects , Humans , Male , Memory/drug effects , Naphthyridines , Radioimmunoassay , Reaction Time/drug effects , Sulfur CompoundsABSTRACT
The pertinency of the visual evoked potentials (VEP) was studied as an index of depression in a group of 50 depressed patients (according to DSM III criteria). The VEP recordings were realized before an antidepressive treatment (D0) and 4 weeks after the beginning of the treatment (D28). Identical recordings were realized with 15 healthy and voluntary reference subjects. Stimulations were reversal checkerboard. The analysis of the results indicate at D0 a reduction of P1 and N1 latencies in the depressed people compared to the reference subjects, and an increase of the P1-N1 amplitude. These differences disappear at D28 (after the antidepressive treatment), as we don't notice any significative difference between D0 and D28 with the reference subjects. The interpretation of these results leads to the hypothesis of a neurophysiological modification of the attentional processes during the depression state. The antidepressive treatment seems merely to produce a normalization of the evoked responses in the depressed patients.
Subject(s)
Depression/physiopathology , Evoked Potentials, Visual , Adult , Antidepressive Agents/therapeutic use , Depression/drug therapy , Female , Humans , Male , Methods , Middle AgedABSTRACT
The study of the attention process during depression has been realized with the recording of visual evoked potential (VEP) by simple pattern reversal checkerboard and in sequences where a rare stimulus appears randomly, with or without task. The recordings obtained on fifty patients have been compared to the VEP obtained on fifteen reference subjects. The results indicate that some perturbations, characteristic of the depressive state, should happen at the both levels of attentional selection, early (P1 and N1 components) and late (P3 component). The responses of the depressive patients appear to reflect rather an intervention of automatic attention process.
Subject(s)
Attention , Depressive Disorder/physiopathology , Evoked Potentials, Visual , Adult , Depressive Disorder/psychology , Female , Humans , Male , Middle AgedABSTRACT
The study of the attention process during depression has been realized with the recording of visual evoked potentials (VEP) by simple pattern reversal checkerboard, and in sequences where a rare stimulus appears randomly, with of without task. The recordings obtained on fifty patients before antidepressive treatment (D0) have been compared to the VEP obtained on the same patients at the end of the treatment (D28) and to those obtained on fifteen reference subjects. The results indicate that some perturbations, characteristic of the depressive state, should happen at both levels of attentional selection, early (components P1 and N1) and late (component P3). The responses of the depressive patient appear to reflect rather the intervention of automatic attention process. Electrophysiological and behavioral data seem to indicate a positive effect of the psychotropic treatment.
Subject(s)
Attention , Depressive Disorder/psychology , Evoked Potentials, Visual , Adult , Antidepressive Agents/therapeutic use , Attention/drug effects , Depressive Disorder/drug therapy , Depressive Disorder/physiopathology , Female , Humans , Male , Middle AgedABSTRACT
In the present study, clinical interview, Visual Evoked Potentials, psychological tests, TRH test, plasmatic MHPG dosage were investigated in 30 depressed patients with major depressive disorders. All the explorations were realised before and after 28 days of an antidepressant treatment. Thanks to analysis we found out the value of psychological tests. The study of evoked potentials brings to light the existence of electrophysiological variables, subordinate to the clinical state. On the contrary, "TRH Test" does not give us any useful indication, and plasmatic MOPEG dosage, although it confirms the existence of two groups of depressed patients, does not suggest any relationship with evolutive types.
