ABSTRACT
The levels of fibrinogen, monomeric fibrin soluble complexes (MFSC), fibrin-fibrinogen degradation products (FDP), and the status of blood coagulation and fibrinolytic systems were studied in girls suffering from juvenile uterine bleedings. Fibrinogen and MFSC levels were found lowered and FDP concentration increased in such bleedings. Fibrinogen concentration correlated with the activities of the coagulating and fibrinolytic systems, and the MFSC level only with the coagulating system activity. Mathematical analysis has revealed a relationship between blood fibrinogen metabolism and the activities of the coagulating and fibrinolytic systems, whose functions in this condition are relatively autonomous.
Subject(s)
Fibrinogen/metabolism , Uterine Hemorrhage/blood , Adolescent , Age Factors , Blood Coagulation , Child , Female , Fibrin/metabolism , Fibrin Fibrinogen Degradation Products/metabolism , Fibrinolysis , Humans , Uterine Hemorrhage/metabolismABSTRACT
Fibrinogen metabolism was studied with the use of coagulation and enzyme immunoassay techniques for measuring its concentrations and the levels of fibrinogen (fibrin) degradation products and of monomer fibrin soluble complexes in adults and children in health and disease. The detected age-associated and nosologic changes in fibrinogen and its metabolites' concentrations are discussed, as is the practical value of the methods employed.
Subject(s)
Fibrinogen/metabolism , Abdominal Injuries/blood , Adolescent , Adult , Aging/blood , Asthma/blood , Child , Female , Humans , Male , Metrorrhagia/blood , Middle Aged , Thoracic Injuries/bloodABSTRACT
A clinico-experimental investigation of the state of the coagulating, fibrinolytic and Kallikrein-Kinin systems of blood in the mechanical jaundice syndrome and different methods of its operative treatment has shown activation of these systems. In jaundice resulting from tumor of the pancreas head and Vater papilla activation of the coagulating system was prevailing while activation of the fibrinolytic and Kallikrein-Kinin systems prevailed in non-tumorous jaundice. The operative treatment aimed at the recovery of choledynamics resulted in normalization of the coagulating, fibrinolytic and Kallikrein-Kinin systems. Continuous bile loss through an external biliary fistula leads to their progressive suppression.
Subject(s)
Blood Coagulation , Cholestasis/blood , Kallikreins/blood , Adult , Aged , Animals , Aprotinin/blood , Cholestasis/surgery , Dogs , Female , Fibrinolysis , Humans , Male , Middle Aged , Prekallikrein/analysisABSTRACT
The investigation of the system of control of the aggregation properties of blood was carried on in 50 patients with closed traumas of chest in early terms after trauma. Activation of hemostasis was detected which was developing by the type of subacute syndrome of disseminated intravascular coagulation. The cause of these changes is thought to be a release of activators of the coagulating system and thrombocyte aggregation factors into the blood flow from the injury focus. High hemostatic potential is responsible for the disturbed microcirculation participating in pathogenesis of complications observed in closed traumas of the chest.
