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AIDS Res Hum Retroviruses ; 16(17): 1921-6, 2000 Nov 20.
Article in English | MEDLINE | ID: mdl-11118078

ABSTRACT

Thirty HIV-1-positive samples from Bolivia were genetically characterized on the basis of HMA and DNA sequencing, revealing the presence of B and F subtypes, in accordance with the molecular epidemiology pattern already described for other South American countries such as Brazil and Argentina. The interpatient divergence of subtype B Bolivian specimens was on average 14.2% (4.3-19.8%) at the nucleotide level, whereas the two unlinked subtype F samples (BO23 and BO29) were only 8.2% divergent, suggesting a more recent introduction of this subtype in the country. In our study group, which represents 13% of the HIV/AIDS cases already described in Bolivia as of May 1996, the transmission occurred more frequently through heterosexual exposures (46.7%), followed by homosexual (23.3%), bisexual (10%), intravenous drug use (3.3%), and vertical (3.3%); in one case the potential exposure category could not be defined (3.3%). No association could be established between exposure categories, gender, or clinical classification and subtype distribution in the Bolivian HIV/AIDS patients.


Subject(s)
HIV Infections/epidemiology , HIV Infections/virology , HIV-1/classification , HIV-1/genetics , Adult , Amino Acid Sequence , Bolivia/epidemiology , DNA, Viral/analysis , DNA, Viral/genetics , Female , HIV Envelope Protein gp120/genetics , Heteroduplex Analysis , History, Medieval , Humans , Male , Middle Aged , Molecular Sequence Data , Peptide Fragments/genetics , Phylogeny , Polymerase Chain Reaction/methods , Sequence Analysis, DNA
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