ABSTRACT
Five cases of carcinoma metastatic to intracranial meningioma or neurilemoma are presented and compared with 20 similar cases reported in the literature. The phenomenon was most often seen on autopsy (17 of 25 cases) and was found more commonly in females (3:2), with nearly 90% of donor cancers being found in breast or lung. The existence of the donor tumor, which was always found to be widely disseminated, was known prior to autopsy in only half the cases.
Subject(s)
Adenocarcinoma/secondary , Meningeal Neoplasms/secondary , Meningioma/secondary , Neoplasms, Multiple Primary/pathology , Neuroma, Acoustic/secondary , Adult , Aged , Breast Neoplasms , Female , Humans , Lung Neoplasms , Male , Meningeal Neoplasms/pathology , Meningioma/pathology , Middle Aged , Neuroma, Acoustic/pathology , Prostatic NeoplasmsABSTRACT
Thirty cases of chordoma were reviewed with respect to the incidence of distant metastases. Follow-up information was obtained in 27 (90%), and the incidence of metastases was approximately 30%. The sites of the metastasizing primary tumors were predominantly sacral and vertebral. The sites of the metastases were predominantly skin and bone, although metastases were found in the lungs and lymph nodes. In two of the three patients with dermal metastases, the metastases were present prior to the diagnosis of the primary lesions. All three dermal metastases were initially diagnosed as mixed tumors of the skin, and all three patients had at least four such lesions of the skin. Accurate prediction of which chordomas will eventually metastasize is difficult. Clinically, local aggressiveness and radiotherapy were positively correlated with this ability; histologically, more anaplastic chordomas were more likely to metastasize.