2-Hydr-oxy-10-propargylpyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione monohydrate.

The title compound, C(15)H(14)N(2)O(3)·H(2)O, consists of a benzodiazepinedione system fused to a pyrrole system. The seven-membered ring adopts a boat-shaped conformation (with the methine C atom as the prow); the five-membered ring adopts an enveloped-shaped conformation (with the hydr-oxy-bearing C atom as the flap). In the crystal, adjacent mol-ecules are linked by O-H⋯O hydrogen bonds into sheets parallel to (102). In addition, C(acetyl-inic)-H⋯O hydrogen bonds occur.

2-Hydr-oxy-10-phenacyl-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione.

The title compound, C(20)H(18)N(2)O(4), consists of a benzodiazepinedione system fused to a pyrrole system. The seven-membered ring adopts a boat-shaped conformation (with the methine C atom as the prow); the five-membered ring adopts an enveloped-shaped conformation (with the hydr-oxy-bearing C atom as the flap). In the crystal, the hydr-oxy group is hydrogen bonded to the carbonyl O atom of an adjacent mol-ecule, generating a zigzag chain.

Ethyl 2-hydr-oxy-5,11-dioxopyrrolo[2,1-c][1,4]benzodiazepine-10-acetate.

The title compound, C(16)H(18)N(2)O(5), consists of a benzodiazepinedione system fused to a pyrrole system. The seven-membered ring adopts a boat-shaped conformation (with the methine C atom as the prow); the five-membered ring adopts an enveloped-shaped conformation (with the hydr-oxy-bearing C atom as the flap). The hydr-oxy group is hydrogen bonded to the carbonyl O atom of an adjacent mol-ecule generating a zigzag chain in the crystal structure.

[Synthesis and pharmacological study of 7-phenyl-1,4-diazepin-5-one and its derivatives]. / Synthèse et étude pharmacologique de dérivés de la 1,4-diazépin-5-one.

We studied the synthesis and psychotropic activity of the 7-phenyl-1,4-diazepin-5-one and derivatives. It can be conclude that these products have sedative, myorelaxant and anxiolytic actions. The toxicity study demonstrated that two diazepines are non-toxic at therapeutic dosages but that a third compound is very toxic.