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Chabamide, a novel piperine dimer from stems of Piper chaba.

Rukachaisirikul, Thitima; Prabpai, Samran; Champung, Penprapa; Suksamrarn, Apichart.

Planta Med ; 68(9): 853-5, 2002 Sep.

Article in English | MEDLINE | ID: mdl-12357406

ABSTRACT

A novel piperine dimer, named chabamide, was isolated from stems of Piper chaba Hunter and its structure was elucidated on the basis of spectroscopic evidence. Chabamide showed antimalarial activity with an IC(50) value of 2.7 microg/ml and antituberculosis activity with the minimum inhibitory concentration (MIC) of 12.5 microg/ml.

Subject(s)

Alkaloids , Piper , Piperidines/chemistry , Plant Extracts/chemistry , Plant Stems/chemistry , Animals , Antimalarials/chemistry , Antimalarials/isolation & purification , Antimalarials/pharmacology , Antitubercular Agents/chemistry , Antitubercular Agents/isolation & purification , Antitubercular Agents/pharmacology , Benzodioxoles , Dimerization , Inhibitory Concentration 50 , Magnetic Resonance Spectroscopy , Mycobacterium tuberculosis/drug effects , Piperidines/isolation & purification , Piperidines/pharmacology , Plant Extracts/isolation & purification , Plant Extracts/pharmacology , Plasmodium falciparum/drug effects , Polyunsaturated Alkamides

ABSTRACT

Subject(s)

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