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Postgrad Med J ; 78(915): 47-8, 2002 Jan.
Article in English | MEDLINE | ID: mdl-11796874

ABSTRACT

A case of necrotising fasciitis in a patient receiving infliximab, an antitumour necrosis factor alpha (TNF-alpha) agent for rheumatoid arthritis, is presented. A widespread confluent, erythematous, pustular skin rash was the presenting sign. There was no fever throughout this admission. beta-Haemolytic group A streptococcus was isolated from blood cultures and skin swabs. The adductor muscles and fascia around the site of a previous hip arthroplasty were necrotic on exploration. The case highlights the risk of severe sepsis in patients on anti-TNF-alpha treatment.


Subject(s)
Antibodies, Monoclonal/adverse effects , Antirheumatic Agents/adverse effects , Arthritis, Rheumatoid/drug therapy , Fasciitis, Necrotizing/chemically induced , Arthroplasty, Replacement, Hip/adverse effects , Drug Eruptions/etiology , Drug Therapy, Combination , Fatal Outcome , Humans , Infliximab , Male , Methotrexate/therapeutic use , Middle Aged
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