Subject(s)
Botulinum Toxins/adverse effects , Mycobacteriaceae/isolation & purification , Mycobacterium Infections/chemically induced , Neuromuscular Agents/adverse effects , Skin Diseases, Bacterial/chemically induced , Adult , Female , Humans , Mycobacterium Infections/microbiology , Skin Diseases, Bacterial/microbiologyABSTRACT
Hydroxychloroquine is being used for COVID-19 symptoms and in clinical trials, but can cause a toxic myopathy that leads to muscle weakness. A review of skeletal muscle biopsies from patients with hydroxychloroquine myopathy gives pointers of steps that can be taken to diagnose this toxic myopathy early and help differentiate it from COVID-19-related muscle weakness.
Subject(s)
COVID-19/diagnosis , Hydroxychloroquine/adverse effects , Muscle Weakness/chemically induced , Muscle Weakness/diagnosis , Muscular Diseases/chemically induced , Muscular Diseases/diagnosis , Adult , Aged , Aged, 80 and over , Antirheumatic Agents/administration & dosage , Antirheumatic Agents/adverse effects , Diagnosis, Differential , Humans , Hydroxychloroquine/administration & dosage , Middle Aged , PandemicsABSTRACT
Eosinophilic cellulitis is a rare inflammatory skin disease of unknown aetiology, first described by George Wells in 1971 as a recurrent granulomatous dermatitis with eosinophilia. It is typically characterised by recurrent pruritic erythematous plaques, vesicles or bullae usually involving the extremities and trunk. Many cases of eosinophilic cellulitis are difficult to treat and traditionally require long course of oral steroids, resulting in steroid side effects. This case adds to the literature in that we report the use of methotrexate to treat eosinophilic cellulitis, as a safe and efficacious therapeutic alternative.
Subject(s)
Cellulitis/drug therapy , Dermatologic Agents/therapeutic use , Eosinophilia/drug therapy , Methotrexate/therapeutic use , Adult , Cellulitis/etiology , Female , HumansABSTRACT
Dermatitis artefacta is a self-inflicted cutaneous disease presenting as sharply delineated ulcers, usually in accessible sites such as the head and neck. IgG4-related disease (IgG4-RD) is a recently recognised immune-mediated condition causing a fibroinflammatory process, resulting in the formation of tumefactive lesions in various organs, rarely presenting primarily in the skin. We report a case of cutaneous IgG4-RD clinically presenting as dermatitis artefacta.