ABSTRACT
A 5-year-old boy was vaccinated with the Oka strain of varicella zoster virus vaccine before cord blood transplant for chronic granulomatous disease in 2005. In 2006, he developed herpes zoster on his left arm. DNA from the vesicular rash confirmed the Oka vaccine strain of varicella zoster virus caused this complication. He responded well to 10 days of aciclovir treatment.
Subject(s)
Chickenpox Vaccine/adverse effects , Fetal Blood/transplantation , Herpes Zoster/chemically induced , Acyclovir/therapeutic use , Antiviral Agents/therapeutic use , Child, Preschool , Granulomatous Disease, Chronic/therapy , Herpes Zoster/drug therapy , Humans , MaleABSTRACT
Zygomycosis in patients with persistent neutropenia had been associated with poor outcomes despite aggressive surgical and antifungal therapy. We describe the case of a 10-year-old girl with aplastic anaemia and persistent neutropenia who developed cutaneous and subcutaneous zygomycosis of her right thigh that was successfully treated with extensive surgical debridement, intravenous liposomal amphotericin B, later changed to oral posaconazole for long-term suppressive therapy and granulocyte colony stimulating factor.
