ABSTRACT
Enzyme-linked immunosorbent assay (ELISA) was carried out in Gimvi village, India, using antigens derived from S. haematobium and S. mansoni adult worms. Patients excreting schistosome ova in urine elicited positive ELISA titres, whereas patients who were previously positive but are no longer passing viable eggs were negative for ELISA.
Subject(s)
Enzyme-Linked Immunosorbent Assay , Schistosomiasis haematobia/diagnosis , Schistosomiasis mansoni/diagnosis , Animals , Antibodies, Helminth/blood , Antigens, Helminth , Humans , India/epidemiology , Schistosoma haematobium/immunology , Schistosoma mansoni/immunology , Schistosomiasis haematobia/epidemiology , Schistosomiasis mansoni/epidemiologyABSTRACT
The effects of the administration of ICRC antileprosy vaccine on skin reactions and lymphocyte transformation tests (LTT) to antigens of Mycobacterium leprae have been investigated in Hanuman langur monkeys (Presbytis entellus) which live native to north India. In a majority of these monkeys, the vaccine brings about lepromin conversion associated with a change in tissue response consistent with "ugrading" of immunity. However, no concomitant changes were observed in the LTT. The significance of these observations is discussed. It is proposed that the langur monkey could be used as a laboratory model to screen "candidate" antileprosy vaccines.
