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1.
PLoS One ; 18(8): e0288681, 2023.
Article in English | MEDLINE | ID: mdl-37527236

ABSTRACT

Topic modelling with innovative deep learning methods has gained interest for a wide range of applications that includes COVID-19. It can provide, psychological, social and cultural insights for understanding human behaviour in extreme events such as the COVID-19 pandemic. In this paper, we use prominent deep learning-based language models for COVID-19 topic modelling taking into account data from the emergence (Alpha) to the Omicron variant in India. Our results show that the topics extracted for the subsequent waves had certain overlapping themes such as governance, vaccination, and pandemic management while novel issues aroused in political, social and economic situations during the COVID-19 pandemic. We also find a strong correlation between the major topics with news media prevalent during the respective time period. Hence, our framework has the potential to capture major issues arising during different phases of the COVID-19 pandemic which can be extended to other countries and regions.


Subject(s)
COVID-19 , Deep Learning , Social Media , Humans , COVID-19/epidemiology , COVID-19/psychology , SARS-CoV-2 , Pandemics
2.
PLoS One ; 18(5): e0285719, 2023.
Article in English | MEDLINE | ID: mdl-37200352

ABSTRACT

Due to the high mutation rate of the virus, the COVID-19 pandemic evolved rapidly. Certain variants of the virus, such as Delta and Omicron emerged with altered viral properties leading to severe transmission and death rates. These variants burdened the medical systems worldwide with a major impact to travel, productivity, and the world economy. Unsupervised machine learning methods have the ability to compress, characterize, and visualize unlabelled data. This paper presents a framework that utilizes unsupervised machine learning methods to discriminate and visualize the associations between major COVID-19 variants based on their genome sequences. These methods comprise a combination of selected dimensionality reduction and clustering techniques. The framework processes the RNA sequences by performing a k-mer analysis on the data and further visualises and compares the results using selected dimensionality reduction methods that include principal component analysis (PCA), t-distributed stochastic neighbour embedding (t-SNE), and uniform manifold approximation projection (UMAP). Our framework also employs agglomerative hierarchical clustering to visualize the mutational differences among major variants of concern and country-wise mutational differences for selected variants (Delta and Omicron) using dendrograms. We also provide country-wise mutational differences for selected variants via dendrograms. We find that the proposed framework can effectively distinguish between the major variants and has the potential to identify emerging variants in the future.


Subject(s)
COVID-19 , Unsupervised Machine Learning , Humans , Algorithms , Pandemics , COVID-19/epidemiology , COVID-19/genetics , SARS-CoV-2/genetics
3.
Comput Methods Programs Biomed ; 231: 107421, 2023 Apr.
Article in English | MEDLINE | ID: mdl-36805280

ABSTRACT

BACKGROUND AND OBJECTIVES: The use of machine learning methods for modelling bio-systems is becoming prominent which can further improve bio-medical technologies. Physics-informed neural networks (PINNs) can embed the knowledge of physical laws that govern a system during the model training process. PINNs utilise differential equations in the model which traditionally used numerical methods that are computationally complex. METHODS: We integrate PINNs with an entangled ladder network for modelling respiratory systems by considering a lungs conduction zone to evaluate the respiratory impedance for different initial conditions. We evaluate the respiratory impedance for the inhalation phase of breathing for a symmetric model of the human lungs using entanglement and continued fractions. RESULTS: We obtain the impedance of the conduction zone of the lungs pulmonary airways using PINNs for nine different combinations of velocity and pressure of inhalation. We compare the results from PINNs with the finite element method using the mean absolute error and root mean square error. The results show that the impedance obtained with PINNs contrasts with the conventional forced oscillation test used for deducing the respiratory impedance. The results show similarity with the impedance plots for different respiratory diseases. CONCLUSION: We find a decrease in impedance when the velocity of breathing is lowered gradually by 20%. Hence, the methodology can be used to design smart ventilators to the improve flow of breathing.


Subject(s)
Lung , Respiration , Humans , Electric Impedance , Neural Networks, Computer , Respiratory Rate
4.
PLoS One ; 17(9): e0273476, 2022.
Article in English | MEDLINE | ID: mdl-36048840

ABSTRACT

The Upanishads are known as one of the oldest philosophical texts in the world that form the foundation of Hindu philosophy. The Bhagavad Gita is the core text of Hindu philosophy and is known as a text that summarises the key philosophies of the Upanishads with a major focus on the philosophy of karma. These texts have been translated into many languages and there exist studies about themes and topics that are prominent; however, there is not much done using language models which are powered by deep learning. In this paper, we use advanced language models such as BERT to provide topic modelling of the Upanishads and the Bhagavad Gita. We then map those topics of the Bhagavad Gita and the Upanishads since it is well known that Bhagavad Gita summarizes the key messages in the Upanishads. We also analyse the distinct and overlapping topics amongst the texts and visualise the link of selected texts of the Upanishads with the Bhagavad Gita. Our results show very high similarity between the topics of these two texts with the mean cosine similarity of 73%. We find that out of the fourteen topics extracted from the Bhagavad Gita, nine of them have a cosine similarity of more than 70% with the topics of the Upanishads. We also find that topics generated by the BERT-based models show very high coherence when compared to the conventional models. Our best-performing model gives a coherence score of 73% on the Bhagavad Gita and 69% on the Upanishads. The visualization of the low-dimensional embeddings of these texts shows very clear overlapping themes among their topics adding another level of validation to our results.


Subject(s)
Artificial Intelligence , Hinduism , Language , Philosophy
5.
Comput Biol Med ; 144: 105338, 2022 05.
Article in English | MEDLINE | ID: mdl-35248805

ABSTRACT

In the past decade, deep learning models have been applied to bio-sensors used in a body sensor network for prediction. Given recent innovations in this field, the prediction accuracy of novel models needs to be evaluated for bio-signals. In this paper, we evaluate the performance of deep learning models for respiratory rate prediction. We consider three datasets from bio-sensors which include electrocardiogram (ECG), photoplethysmogram (PPG) data, and surface electromyogram (sEMG) data. The deep learning models include Long short-term memory (LSTM) networks, Bidirectional LSTM (Bi-LSTM), attention-based variants of LSTM, CNN-LSTM and Convolutional-LSTM networks. The deep learning models are evaluated for two separate windows which are 32 s and 64 s window. The models' performance is evaluated using mean absolute error (MAE). The 64 s window has more accurate prediction compared to the 32 s window. Our results indicate Bi-LSTM with Bahdanu Attention has the best performance for the bio-signals. LSTM performs best with one of the datasets, yielding an MAE of 0.70 ± 0.02. Bi-LSTM with Bahdanau attention showed best results with two of the three datasets with MAE of 0.51 ± 0.03 for sEMG based data and MAE of 0.24 ± 0.03 with PPG and ECG based data.


Subject(s)
Deep Learning , Electrocardiography , Electromyography , Neural Networks, Computer , Respiratory Rate
6.
PLoS One ; 17(1): e0262708, 2022.
Article in English | MEDLINE | ID: mdl-35089976

ABSTRACT

The COVID-19 pandemic continues to have major impact to health and medical infrastructure, economy, and agriculture. Prominent computational and mathematical models have been unreliable due to the complexity of the spread of infections. Moreover, lack of data collection and reporting makes modelling attempts difficult and unreliable. Hence, we need to re-look at the situation with reliable data sources and innovative forecasting models. Deep learning models such as recurrent neural networks are well suited for modelling spatiotemporal sequences. In this paper, we apply recurrent neural networks such as long short term memory (LSTM), bidirectional LSTM, and encoder-decoder LSTM models for multi-step (short-term) COVID-19 infection forecasting. We select Indian states with COVID-19 hotpots and capture the first (2020) and second (2021) wave of infections and provide two months ahead forecast. Our model predicts that the likelihood of another wave of infections in October and November 2021 is low; however, the authorities need to be vigilant given emerging variants of the virus. The accuracy of the predictions motivate the application of the method in other countries and regions. Nevertheless, the challenges in modelling remain due to the reliability of data and difficulties in capturing factors such as population density, logistics, and social aspects such as culture and lifestyle.


Subject(s)
COVID-19/epidemiology , Deep Learning , Epidemiological Models , Forecasting , Humans , India/epidemiology , Neural Networks, Computer
7.
PLoS One ; 16(8): e0255615, 2021.
Article in English | MEDLINE | ID: mdl-34411112

ABSTRACT

Social scientists and psychologists take interest in understanding how people express emotions and sentiments when dealing with catastrophic events such as natural disasters, political unrest, and terrorism. The COVID-19 pandemic is a catastrophic event that has raised a number of psychological issues such as depression given abrupt social changes and lack of employment. Advancements of deep learning-based language models have been promising for sentiment analysis with data from social networks such as Twitter. Given the situation with COVID-19 pandemic, different countries had different peaks where rise and fall of new cases affected lock-downs which directly affected the economy and employment. During the rise of COVID-19 cases with stricter lock-downs, people have been expressing their sentiments in social media. This can provide a deep understanding of human psychology during catastrophic events. In this paper, we present a framework that employs deep learning-based language models via long short-term memory (LSTM) recurrent neural networks for sentiment analysis during the rise of novel COVID-19 cases in India. The framework features LSTM language model with a global vector embedding and state-of-art BERT language model. We review the sentiments expressed for selective months in 2020 which covers the major peak of novel cases in India. Our framework utilises multi-label sentiment classification where more than one sentiment can be expressed at once. Our results indicate that the majority of the tweets have been positive with high levels of optimism during the rise of the novel COVID-19 cases and the number of tweets significantly lowered towards the peak. We find that the optimistic, annoyed and joking tweets mostly dominate the monthly tweets with much lower portion of negative sentiments. The predictions generally indicate that although the majority have been optimistic, a significant group of population has been annoyed towards the way the pandemic was handled by the authorities.


Subject(s)
COVID-19 , Deep Learning , Models, Biological , Models, Psychological , Pandemics , SARS-CoV-2 , Social Media , COVID-19/epidemiology , COVID-19/psychology , Humans , India/epidemiology
8.
PLoS One ; 16(7): e0253217, 2021.
Article in English | MEDLINE | ID: mdl-34197473

ABSTRACT

Recently, there has been much attention in the use of machine learning methods, particularly deep learning for stock price prediction. A major limitation of conventional deep learning is uncertainty quantification in predictions which affect investor confidence. Bayesian neural networks feature Bayesian inference for providing inference (training) of model parameters that provides a rigorous methodology for uncertainty quantification in predictions. Markov Chain Monte Carlo (MCMC) sampling methods have been prominent in implementing inference of Bayesian neural networks; however certain limitations existed due to a large number of parameters and the need for better computational resources. Recently, there has been much progress in the area of Bayesian neural networks given the use of Langevin gradients with parallel tempering MCMC that can be implemented in a parallel computing environment. The COVID-19 pandemic had a drastic impact in the world economy and stock markets given different levels of lockdowns due to rise and fall of daily infections. It is important to investigate the performance of related forecasting models during the COVID-19 pandemic given the volatility in stock markets. In this paper, we use novel Bayesian neural networks for multi-step-ahead stock price forecasting before and during COVID-19. We also investigate if the pre-COVID-19 datasets are useful of modelling stock price forecasting during COVID-19. Our results indicate due to high volatility in the stock-price during COVID-19, it is more challenging to provide forecasting. However, we found that Bayesian neural networks could provide reasonable predictions with uncertainty quantification despite high market volatility during the first peak of the COVID-19 pandemic.


Subject(s)
Bayes Theorem , COVID-19/epidemiology , Investments , Forecasting , Humans , Marketing , Neural Networks, Computer , Pandemics
9.
IEEE Trans Neural Netw Learn Syst ; 26(12): 3123-36, 2015 Dec.
Article in English | MEDLINE | ID: mdl-25769175

ABSTRACT

Collaboration enables weak species to survive in an environment where different species compete for limited resources. Cooperative coevolution (CC) is a nature-inspired optimization method that divides a problem into subcomponents and evolves them while genetically isolating them. Problem decomposition is an important aspect in using CC for neuroevolution. CC employs different problem decomposition methods to decompose the neural network training problem into subcomponents. Different problem decomposition methods have features that are helpful at different stages in the evolutionary process. Adaptation, collaboration, and competition are needed for CC, as multiple subpopulations are used to represent the problem. It is important to add collaboration and competition in CC. This paper presents a competitive CC method for training recurrent neural networks for chaotic time-series prediction. Two different instances of the competitive method are proposed that employs different problem decomposition methods to enforce island-based competition. The results show improvement in the performance of the proposed methods in most cases when compared with standalone CC and other methods from the literature.


Subject(s)
Algorithms , Competitive Behavior , Cooperative Behavior , Neural Networks, Computer , Animals , Biological Evolution , Humans , Time Factors
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