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Int J Gynaecol Obstet ; 146(2): 170-176, 2019 Aug.
Article in English | MEDLINE | ID: mdl-31074835

ABSTRACT

OBJECTIVE: To examine the feasibility of implementing a high-risk HPV (hrHPV) DNA-based screening program for cervical cancer and the prevalence of hrHPV DNA-positive women in a community setting in rural India. METHODS: A cross-sectional study was conducted at the community level in the Hunsur taluk of the Mysore district from January to August 2016. Cervical cancer screening was conducted with self-collected vaginal samples that were analyzed using the Hybrid Capture 2 (HC2) assay (Qiagen, USA). RESULTS: The majority of participants were aged 30-39 years, with no formal schooling, from a lower caste, and lived below an annual household income of US$1499. After group health education and one-on-one counseling, a total of 473 women underwent self-sampling. Of these, 36 (7.6%) were positive for hrHPV and only 24 (66.6%) underwent follow-up diagnostic triaging. Cancer was detected in two women, who were referred to appropriate healthcare facilities for further treatment. CONCLUSION: Implementation of hrHPV DNA-based screening tests using self-sampling can be feasible in rural settings in India. However, substantial resources are required for providing health education and one-on-one counseling to inform asymptomatic women about the benefits of testing and, more importantly, to improve compliance with follow-up.


Subject(s)
Papillomavirus Infections/diagnosis , Vaginal Smears/methods , Adult , Cross-Sectional Studies , DNA, Viral/genetics , Early Detection of Cancer/methods , Female , Humans , India , Mass Screening/methods , Mass Screening/statistics & numerical data , Middle Aged , Papillomavirus Infections/epidemiology , Pregnancy , Prevalence , Surveys and Questionnaires , Uterine Cervical Neoplasms/diagnosis , Uterine Cervical Neoplasms/virology
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